Search trials – HealthDB

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Намерени 4,781 изпитвания Стр. 79 от 240

Recruiting

Determining Elements of Anti-Fungal Immunity in BURN Patients

Burn

Scientific justification Invasive fungal diseases (IFDs) pose a substantial threat, especially in immunocompromised patients, necessitating urgent research focus and therapeutic advancements. The IFI-BURN study, involving a cohort of patients with severe burn injury (n=276), revealed a significant IFD incidence of 31.6% and underscored their critical impact on morbidity and mortality. While fungi are present everywhere, for moulds within the environment and for yeasts within our microbiota, why certain patients develop IFDs and others do not, remains poorly understood. The answer most likely resides in the impact of the burn injury on the immune response, loss of skin barrier and particular predisposing immune phenotype of patients. The immune system is composed of both cellular and humoral components, but the latter is far less studied in antifungal immunity although they exert multiple antimicrobial mechanisms.

Начало: 23.04.2025 Край: 23.10.2030 Възраст: от 18 г.

France Assistance Publique - Hôpitaux de Paris NCT06828458

Recruiting

Patient Voice in the Treatment of Low-grade Gliomas: Use of Patient-reported Outcomes, Vorasidenib and Radiotherapy Compared

Glioma Glioma of Brain Low Grade Glioma of Brain Low Grade Gliomas +1

The study aims to assess the direct patient-reported perception (PROs) of individuals affected by IDH-mutant, grade 2 gliomas undergoing radiotherapy or pharmacological treatment with vorasidenib. To evaluate quality of life, perception of treatment-related symptoms, and anxiety levels during therapy by comparing patients receiving radiotherapy with those receiving pharmacological treatment with vorasidenib. The control group will consist of patients with IDH-mutant, grade 2 gliomas who are under clinical and radiological follow-up only. To assess the feasibility of using PROMs in routine clinical practice. To analyze patient-reported critical issues in order to qualitatively improve care pathways.

Начало: 23.04.2025 Край: 01.10.2027 Възраст: от 18 г.

Italy Fondazione I.R.C.C.S. Istituto Neurologico Carlo Besta NCT07547163

Recruiting

Pivotal Study for the Cardiac Performance System (CPS)

Cardiovascular Diseases

This multi-center, observational study evaluates the accuracy of the Cardiac Performance System (CPS), a non-invasive device, for measuring hemodynamic parameters in adult patients undergoing clinically indicated right heart catheterization. The study compares CPS measurements to invasive measurements to assess agreement and potential clinical utility.

Начало: 22.04.2025 Край: 30.05.2026 Възраст: от 18 г.

United States Sensydia Corporation NCT06870591

Recruiting

"Pseudo-scanner" MRI Sequences for the Detection of Bone Lesions in Multiple Myeloma

Multiple Myeloma Bone Disease

Recent work has confirmed the diagnostic performance of pseudo-CT sequences for detecting osteolytic lesions. Their integration into whole body MRI (WB MRI) could transform the diagnostic approach to MM, by allowing a combined assessment of bone marrow involvement, tissue viability and osteolysis, during a single non-irradiating imaging examination. Since the preliminary work mentioned above, optimizations have been made to the pseudo-CT sequences, including the addition of deep learning (correcting noise in the images) and the correction of chemical shift artifact (linked to the coexistence of hydrated tissue and fatty tissue), which carry real hope of improving their diagnostic potential and accuracy.

Начало: 22.04.2025 Край: 01.11.2027 Възраст: от 18 г.

Belgium Cliniques universitaires Saint-Luc- Université Catholiq NCT06988020

Recruiting Phase 4

Magnesium-L-Threonate for Sleep Quality Post-Arthroplasty

Sleep Knee Osteoarthritis

The study team is conducting a study to see if Magnesium-L-Threonate (MgT) can help improve how well participants sleep and reduce pain after total joint replacement surgery

Начало: 21.04.2025 Край: 01.07.2026 Възраст: от 18 г.

United States University of Miami NCT06902285

Recruiting

Iron Absorption in The Low Oxygen Exposure and Weight Status (LOWS) Study

Obesity (Disorder)

Declines in iron status are common in those with obesity and may be due to obesity-related chronic inflammation; however, the effects of reducing inflammation following diet-induced weight loss on iron metabolism are poorly understood. Low environmental oxygen exposure increases dietary iron absorption and availability to supply iron for erythropoiesis but has not yet been tested in the context of weight loss. This study is designed to investigate diet-induced weight loss (inflammation reduction) and overnight low oxygen exposure (erythropoiesis stimulating agent) as strategies to improve dietary iron absorption in obesity.

Начало: 21.04.2025 Край: 30.06.2026 Възраст: 22–65 г.

United States Pennington Biomedical Research Center NCT07542873

Recruiting Phase 4

Seizure Prevention in Traumatic Brain Injury With Levetiracetam and Lacosamide

Traumatic Brain Injury

The purpose of this study is to assess the incidence of early post-traumatic seizures. The study will also assess the benefit of lacosamide compared to levetiracetam in regards to agitation and behavioral adverse effects in patients with traumatic brain injury requiring seizure prophylaxis.

Начало: 18.04.2025 Край: 01.04.2027 Възраст: от 18 г.

United States Wake Forest University Health Sciences NCT06866691

Recruiting

Pooled Analysis of Single-arm Studies of Budesonide/Glycopyrronium/Formoterol (BGF) in Routine Care Setting

Pulmonary Disease, Chronic Obstructive

The CHOROS pooled analysis is a retrospective secondary data use analysis of integrated individual participant data from a series of planned and on-going primary prospective, non-interventional, multi-center studies sponsored by AstraZeneca and conducted in the pulmonary/primary care practitioner setting in multiple countries and may include data from the following countries: United Kingdom, Germany, Italy, Greece, Japan, Canada and Romania.

Начало: 17.04.2025 Край: 14.12.2026 Възраст: от 18 г.

Canada, Germany, Greece +4 AstraZeneca NCT06712563

Recruiting

Metabolic Impact and Compliance of Controlled, Varying, Mediterranean Diets in Pre-Surgical Prostate Cancer Populations (PROVISIONS)

Prostate Cancer

The study aims to investigate whether following a controlled Mediterranean-style diet prior to robotic-assisted radical prostatectomy surgery in patients diagnosed with prostate cancer affects fasting insulin levels and other values that can be measured in blood and tissue samples from surgery.

Начало: 17.04.2025 Край: 01.05.2027 Възраст: 18–80 г.

United States University of Miami NCT06487507

Recruiting Phase 3

A Trial to Investigate Benralizumab in Children With Eosinophilic Diseases

Eosinophilic Granulomatosis With Polyangiitis (EGPA) Hypereosinophilia Syndrome (HES)

The main purpose of study is to assess the safety, tolerability, pharmacokinetics (PK), and efficacy of benralizumab.

Начало: 17.04.2025 Край: 03.04.2028 Възраст: 6–17 г.

Brazil, Canada, France +7 AstraZeneca NCT06512883

Recruiting Phase 1

A Comparative Study of Pharmacokinetics, Safety, and Immunogenicity of RPH-030 and Vectibix® in Patients With Metastatic Colorectal Cancer With Wild-type RAS as First-line Therapy in Combination With FOLFIRI

Metastatic Colorectal Cancer

The primary objective of this study is to demonstrate equivalence of pharmacokinetic properties, and comparability of safety and immunogenicity parameters of RPH-030 and Vectibix® following a single (first) intravenous administration to patients with mCRC with wild-type RAS genes as 1-line therapy in combination with FOLFIRI. The additional objective is to perform a pilot evaluation of the efficacy of RPH-030 and Vectibix® following a single (first) intravenous administration to patients with mCRC with wild-type RAS genes as 1-line therapy in combination with FOLFIRI.

Начало: 17.04.2025 Край: 01.08.2028 Възраст: от 18 г.

Russia R-Pharm NCT07543744

Recruiting Phase 3

A Phase 3 Study of Ersodetug in Patients With Tumor Hyperinsulinism

Tumor Hyperinsulinism (Tumor HI)

The objectives of this study are to evaluate the glycemic efficacy, safety, and tolerability of ersodetug as add-on to standard of care (SOC) therapy for treatment of hypoglycemia in patients with Tumor Hyperinsulinism (Tumor HI).

Начало: 16.04.2025 Край: 01.09.2027 Възраст: от 18 г.

France, Netherlands, Switzerland +2 Rezolute NCT06881992

Recruiting

The Foods & Oil to Repair, Correct and Enhance Strength (FORCES) Study

Sarcopenia

The proposed research is a parallel arm, randomized placebo-controlled clinical trial designed to assess changes in muscle strength, volume, fatigue resistance, and mobility in older adults after daily consumption of 12g of linoleic acid-rich oil.

Начало: 16.04.2025 Край: 01.05.2030 Възраст: 65–80 г.

United States Ohio State University NCT06361511

Recruiting

GEneRating Mucosal Immunity After INfluenzA Infection and Vaccination in Lung and Lymphoid TissuE

Influenza

This experimental medicine study aims to compare immune responses in healthy adult volunteers aged 18-55 years against influenza vaccination and infection in the upper and lower respiratory tract, following administration of a live-attenuated influenza vaccine delivered by nasal spray versus influenza A (H3N2) viral challenge.

Начало: 16.04.2025 Край: 31.07.2026 Възраст: 18–55 г.

United Kingdom Imperial College London NCT06620185

Recruiting Phase 3

Long-Term Study to Assess the Safety and Tolerability of NBI-1065845 as an Adjunctive Treatment in Participants With Major Depressive Disorder (MDD)

Major Depressive Disorder

This study will evaluate the long-term safety and tolerability of NBI-1065845 as an adjunctive treatment in participants with MDD.

Начало: 16.04.2025 Край: 01.05.2030 Възраст: от 18 г.

Belgium, Bulgaria, Croatia +13 Neurocrine Biosciences NCT06966401

Recruiting

Breathing Patterns in Infants Before and After Extubation

Respiratory Distress Syndrome (RDS) PreTerm Neonate

The primary objective of this study is to compare work of breathing indices before and after extubation in intubated premature infants admitted to the Christiana Care Neonatal Intensive Care Unit. The secondary objective is to compare the ability of work of breathing indices to predict extubation failure to routine spontaneous breathing tests (SBTs) in intubated premature infants admitted to the ChristianaCare NICU.

Начало: 14.04.2025 Край: 01.12.2026 Възраст: до 6 г.

United States Christiana Care Health Services NCT07542301

Recruiting

EXtubation Related Complications - the EXTUBE Study (EXTUBE)

Extubation

EXTUBE is an international, multicentre, prospective cohort study evaluating the incidence, risk factors, and outcomes of extubation-related complications and describing clinical practices related to extubation after general anesthesia or after critical illness in the operating room (OR), out of OR anesthesia location or intensive care unit (ICU).

Начало: 14.04.2025 Край: 01.12.2026 Възраст: от 18 г.

Australia, Canada, Ireland +4 University Health Network, Toronto NCT06442930

Recruiting

Evaluating Pumpkin Seed Oil Extract Supplementation on Bladder Function

Overactive Bladder (OAB)

This is a pilot study to assess using validated outcome measures how ingesting pumpkin seed oil extract supports patient bladder function in a United States population.

Начало: 11.04.2025 Край: 01.10.2026 Възраст: от 18 г.

United States Northwestern University NCT06944392

Recruiting

Effect of Untact Upper Extremity Rehabilitation Using Smart Glove for Late Subacute and Chronic Patients With Brain Disorder

Brain Disorder Home Based Rehabilitation

The aim is to clinically validate the clinical efficacy, usability, and safety of home-based upper limb rehabilitation training using the Neofect Smart Glove by comparing the effects between a group using the home-based Neofect Smart Glove and a group performing conventional home-based occupational therapy in patients with upper limb dysfunction in the late subacute and chronic stages of neurological diseases.

Начало: 11.04.2025 Край: 31.12.2026 Възраст: 19–85 г.

South Korea Samsung Medical Center NCT06837324

Recruiting Phase 2

A Clinical Study of Zilovertamab Vedotin (MK-2140) Plus Rituximab Plus Cyclophosphamide, Doxorubicin, and Prednisone (R-CHP) Versus Polatuzumab Vedotin Plus R-CHP in People With Diffuse Large B-cell Lymphoma (DLBCL) (MK-2140-011/waveLINE-011)

Lymphoma, Large B-Cell, Diffuse

Researchers are looking for ways to treat germinal center B-cell-like diffuse large B-cell lymphoma (GCB DLBCL). DLBCL is a fast-growing blood cancer that affects B-cells. GCB is a type of DLBCL that affects young B-cells that are still maturing. The goal of this study is to learn if more people who receive zilovertamab vedotin (MK-2140) and R-CHP have the cancer respond (go away) than those who receive polatuzumab vedotin and R-CHP.

Начало: 11.04.2025 Край: 16.12.2032 Възраст: от 18 г.

Belgium, Germany, Ireland +6 Merck Sharp & Dohme LLC NCT06890884

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