Търсене на изпитвания

Активни:

Намерени 3,079 изпитвания Стр. 70 от 154

Набира участници Фаза 1/2

Study of DISC-0974 (RALLY-MF) in Participants With Myelofibrosis or Myelodysplastic Syndrome and Anemia

Myelofibrosis; Anemia Anemia Myelofibrosis Myelofibrosis Due to and Following Polycythemia Vera +3

This phase 1b/2a open-label study will assess the safety, tolerability, pharmacokinetics and pharmacodynamics of DISC-0974 as well as categorize the effects on anemia response in subjects with myelofibrosis or myelodysplastic syndrome and anemia.

Начало: 06.06.2022 Край: 01.09.2026 Възраст: от 18 г. Лечение

Australia, United States Disc Medicine, Inc NCT05320198

Набира участници Фаза 1

Study of ORIC-944 in Patients With Metastatic Prostate Cancer

Metastatic Prostate Cancer

The purpose of this study is to establish the safety and preliminary antitumor activity of ORIC-944 as a single agent and in combinations with ARPIs in patients with metastatic prostate cancer.

Начало: 01.06.2022 Край: 01.09.2026 Възраст: от 18 г. Лечение

Australia, Spain, United Kingdom +1 ORIC Pharmaceuticals NCT05413421

Набира участници Фаза 3

A Study of the Efficacy and Safety of DMX-200 in Patients With FSGS Who Are Receiving an ARB

FSGS

DMX-200 (repagermanium) is a C-C chemokine receptor type 2 (CCR2) inhibitor that, when administered concurrently with an ARB, is designed to inhibit recruitment of monocytes implicated in the inflammatory chemokine environment of chronic disease. The purpose of this pivotal randomized double-blind study is to investigate the efficacy and safety of DMX-200 120 mg twice daily (BID) compared with placebo over a treatment period of 104 weeks in adult patients with FSGS who are being treated with an ARB. Given the rarity of the disease and the similarities between adults and pediatric patients with FSGS, Dimerix will also investigate the efficacy and safety of DMX 200 in adolescents aged 12 to 17 years. The double-blind period will be followed by an open-label extension (OLE) which aims to assess the long-term efficacy and safety of DMX 200 for up to 2 additional years.

Начало: 30.05.2022 Край: 01.12.2029 Възраст: 12–80 г. Лечение

Argentina, Australia, Brazil +17 Dimerix Bioscience Pty Ltd NCT05183646

Набира участници Фаза 2/3

A Study Investigating Oral Ozanimod (RPC1063) in Pediatric Participants With Moderate to Severe Active Ulcerative Colitis

Colitis, Ulcerative

The purpose of this study is to evaluate the effectiveness and safety of ozanimod (RPC1063) in achieving and maintaining clinical remission. Ozanimod will be administered orally to pediatric participants with moderate to severe active ulcerative colitis (UC) who have had an inadequate response to conventional therapy.

Начало: 30.05.2022 Край: 14.08.2031 Възраст: 2–17 г. Лечение

Australia, Belgium, Canada +10 Bristol-Myers Squibb NCT05076175

Набира участници Фаза 4

Single Dose Intravenous Antibiotics for Complicated Urinary Tract Infections in Children

Complicated Urinary Tract Infection Infection Pediatric Infectious Disease

Urinary tract infections (UTI) are commonly encountered in children, with 7% diagnosed with at least one UTI by the age of 19 years. The evidence for treatment of uncomplicated UTI is clear; oral antibiotics are as good as intravenous (IV) antibiotics, usually for a total of 7 days. Complicated UTIs (cUTIs) on the other hand, are common reasons for hospital admissions for IV antibiotics and constitute a major burden for healthcare systems. There is considerable variation in care for children who present with UTI and have complicating features such as vomiting, dehydration, urological abnormalities or have a previous history of UTI. Australian and international guidelines lack clear, evidence-based recommendations to guide treatment in this group. Without gold standard evidence, these children will continue to receive unnecessary IV antibiotics, longer hospital stays and poorer health outcomes. This multicentre, non-inferiority randomised trial will investigate if One dose - single dose of IV followed by 2 days oral antibiotics is as non-inferior to Three doses for children with UTI and co-existing complicating factors presenting to the Emergency Department (ED). In other words, this study will compare if a single dose of IV antibiotics plus two days oral antibiotics is as clinically effective as 3 doses antibiotics in resolving UTI symptoms at 72 hours after the first dose of IV antibiotics, for complicated UTIs in children presenting to the ED. All participants will receive a total of 7 days of antibiotics for the complicated urinary tract infection. If 1 dose IV and 2 days oral antibiotics is found to be as good as 3 days, the duration of IV antibiotics for complicated UTI can be reduced along with avoidance of the inherent risks of unnecessary hospital admission by administering a single IV dose in an outpatient/ED setting. On the other hand if a single IV dose results in prolonged symptoms or treatment failure, this will inform practice for the proportion of children who have a single dose of IV antibiotics in the ED and are sent home on oral antibiotics. Regardless of the outcome, this trial will inform clinical practice for complicated UTI to improve health outcomes for this group.

Начало: 30.05.2022 Край: 16.05.2028 Възраст: 3–18 г. Лечение

Australia, New Zealand Murdoch Childrens Research Institute NCT04876131

Набира участници Фаза 1/2

A TRIAL TO EVALUATE THE SAFETY, TOLERABILITY, PHARMACOKINETICS, AND EFFICACY OF SHR-A1904 IN SUBJECTS WITH ADVANCED SOLID TUMORS

Advanced Solid Tumors

The study (dose escalation/expansion) is being conducted to assess the safety and tolerability of SHR-A1904 in subjects with advanced solid tumors, and to determine maximum tolerated dose (MTD) and/or recommended phase II dose (RP2D), to assess preliminary efficacy of SHR-A1904, pharmacokinetic (PK) profile and immunogenicity of SHR-A1904 in subjects with advanced solid tumors.

Начало: 30.05.2022 Край: 30.05.2026 Възраст: от 18 г. Лечение

Australia, Moldova, South Korea +1 Jiangsu HengRui Medicine Co., Ltd. NCT05277168

Набира участници

Post Market Clinical Follow Up of ResMed Mask Systems

Obstructive Sleep Apnea

Post Market follow up study to systematically and proactively collect supplementary real world data to confirm the usability and performance of the new generation mask systems. .

Начало: 26.05.2022 Край: 01.06.2027 Възраст: 18–100 г. Лечение

Australia ResMed NCT05262439

Набира участници

WiserAD: The Effect of a Structured Online Intervention on Antidepressant Deprescribing in Primary Care

Depression

The use of antidepressants (ADs) is increasing globally, including within Australia, which has one of the highest rates of AD prescribing. Despite clear benefits for many people, there is reason to believe that the ongoing use of these medications is often not properly monitored or stopped (deprescribed) when a person returns to better Mental health. This trial sets out to test how well an online support tool (WiserAD) can help patients and their general practitioner to manage the careful and appropriate reducing and stopping of antidepressants, in primary care patients.

Начало: 25.05.2022 Край: 07.08.2025 Възраст: 18–75 г. Лечение

Australia University of Melbourne NCT05355025

Набира участници Фаза 2

The Communicate Study Partnership

Aboriginal Health Cultural Safety Access to Interpreters Healthcare Provider Training

The vision of the Communicate Study Partnership is to ensure more Aboriginal patients receive culturally safe healthcare in their first language. The Communicate Study Partnership will implement and evaluate creative ways to embed cultural safety training and increase use of Aboriginal Interpreters and Aboriginal Health Practitioners at Northern Territory Top End hospitals. Quantitative outcomes (interpreter uptake, outcomes including leave against medical advice, costs) will be measured using time-series analysis. Qualitative outcomes derived from interviews with patient, healthcare provider and interpreter participants, will be informed by decolonising theory and participatory approaches. Successful project implementation will improve experience of care and health outcomes for Aboriginal people, build Aboriginal workforce, and improve healthcare provider satisfaction.

Начало: 23.05.2022 Край: 31.12.2026 Здравни услуги

Australia Menzies School of Health Research NCT05629416

Набира участници Фаза 1

A Phase 1a/1b Study of ELVN-001 for the Treatment Chronic Myeloid Leukemia

Chronic Myeloid Leukemia Chronic Phase Chronic Myeloid Leukemia, BCR-ABL1 Positive Cml

The purpose of this study is to evaluate the safety, tolerability and determine the recommended dose for further clinical evaluation of ELVN-001 in patients with chronic myeloid leukemia with and without T315I mutations in patients who are relapsed, refractory or intolerant to TKIs.

Начало: 22.05.2022 Край: 01.12.2027 Възраст: от 18 г. Лечение

Australia, Belgium, Canada +11 Enliven Therapeutics NCT05304377

Набира участници

SELUTION4BTK Trial

Peripheral Arterial Disease Chronic Limb-Threatening Ischemia Nos of Native Arteries of Extremities

This study aims to demonstrate superior efficacy and equivalent safety of the SELUTION SLR™ DEB 014 compared to plain (uncoated) balloon angioplasty in the treatment of peripheral arterial disease (PAD) in the BTK arteries in CLTI patients.

Начало: 19.05.2022 Край: 30.07.2032 Възраст: от 18 г. Лечение

Austria, France, Germany +7 M.A. Med Alliance S.A. NCT05055297

Набира участници Фаза 2

Viscoelastic Testing Guided Tissue Plasminogen Activator Treatment in Acute Respiratory Failure

Acute Respiratory Failure Hypercoagulability Fibrinolysis Shutdown

Patients with coronavirus disease (COVID) and non-COVID acute respiratory failure (ARF) may be at an increased risk of thrombosis due to increased clot formation and decreased clot lysis. This two stage study aims to utilise bedside coagulation technology to detect patients at increased risk and guide tPA treatment to maximise efficacy and safety through a personalised approach.

Начало: 18.05.2022 Край: 01.12.2026 Възраст: 18–75 г. Лечение

Australia South West Sydney Local Health District NCT05540834

Набира участници

Clinical Utility and Gait Analysis of NextAR System AUS

Total Knee Arthroplasty

This study titled "Does Personalised Soft Tissue Balance Data Improve Outcomes in Patients Undergoing Medially Stabilised Arthroplasty? A Prospective, Randomised Study Investigating the Clinical Utility of the NextAR navigation system (NextAR)" is a randomised, single blinded, prospective cohort study with the primary aim determine the clinical utility of the NextAR system data in providing soft tissue balance patterns to enable prosthesis implants to resemble more native knee alignment.

Начало: 15.05.2022 Край: 01.05.2026 Възраст: от 18 г.

Australia Medacta International SA NCT05863741

Набира участници

The Effect of In-utero Exposure to Metformin in 5-11 Year Old Offspring of Mothers in the MiTy Trial

Diabetes Mellitus, Type 2 Pregnancy in Diabetic Child Obesity Child Development

The incidence of diabetes in pregnancy is rising, with rates of 1 in 7 pregnancies globally. Metformin is used for type 2 diabetes (T2DM) outside of pregnancy and is now increasingly prescribed during pregnancy. There are some concerns as metformin crosses the placenta and effects on offspring exposed during pregnancy are unknown. Animal and human evidence indicate that metformin may create an atypical in-utero environment similar to under-nutrition which has been associated with adult obesity. This is supported by studies in children of mothers treated with metformin in other populations where an increase in childhood obesity was found at 4-9 years of age. We now have evidence from the MiTy trial, that offspring of metformin-exposed women with T2DM have less large infants and are less adipose at birth, but are also more likely to be small for gestational age (SGA). These effects could lead to benefit or harm in the long-term. Offspring of MiTy mothers are currently being followed up to 2 years. Given that long-term effects may not be evident until 5 years of age, it is imperative to follow these children longer. Goals/Research Aims:To determine whether in-utero exposure to metformin, in offspring of women with T2DM, is beneficial or harmful in the long-term. Research Questions: 1. In offspring of women with T2DM, how does treatment with metformin during pregnancy affect a) adiposity b) growth over time c) metabolic syndrome d) cognitive and behavioral measures:2. What factors predict altered childhood adiposity and insulin resistance in these offspring? Primary Outcome: Body mass index (BMI) z-score. Secondary Outcomes: 1) other measures of adiposity (i.e. skinfolds, 2) growth over time 3) measures of insulin resistance 4) adipocytokines 5)neurodevelopment Expected Outcomes Given these increasing concerns, this study will inform the best treatment for pregnant mothers with diabetes by studying the long-term outcomes of children exposed to metformin during pregnancy.

Начало: 11.05.2022 Край: 01.05.2026

Australia, Canada Mount Sinai Hospital, Canada NCT05025852

Набира участници Фаза 2

To Assess the Efficacy, Safety, and Tolerability of INCB000928 in Participants With Fibrodysplasia Ossificans Progressiva

Fibrodysplasia Ossificans Progressiva (FOP)

This Phase 2, Randomized, Double-Blind, Placebo-Controlled Study is intended to evaluate the Efficacy, Safety, and Tolerability and PK of INCB000928 administered to participants with a clinical diagnosis of fibrodysplasia ossificans progressiva (FOP).

Начало: 05.05.2022 Край: 20.01.2033 Възраст: 2–99 г. Лечение

Argentina, Australia, Brazil +14 Incyte Corporation NCT05090891

Набира участници

Real World Data Collection on the Synergy Cervical Disc

Cervical Disc Degeneration

This trial is a real world data (RWD) collection observational study, comprised of both prospective and retrospective arms, that will examine the safety and effectiveness of the Synergy Cervical Disc System in patients with degenerative cervical disc disease.

Начало: 01.05.2022 Край: 01.12.2029 Възраст: от 21 г.

Australia Synergy Spine Solutions NCT05305430

Набира участници Фаза 1/2

Microbial Restoration in Inflammatory Bowel Diseases

Fecal Microbiota Transplantation Crohn Disease Inflammatory Bowel Diseases Microbiome

This is a prospective, two-centre, double-blind, parallel-arm, randomised, placebo-controlled trial evaluating the impact of FMT on patients with active Crohn's disease.

Начало: 01.05.2022 Край: 01.04.2026 Възраст: 18–70 г. Лечение

Australia St Vincent's Hospital Melbourne NCT04970446

Набира участници Фаза 3

Investigate Efficacy and Safety of Carisbamate as Adjunctive Treatment for Seizures Associated With LGS in Children and Adults

Seizures Lennox Gastaut Syndrome

The primary objective is to evaluate the efficacy of carisbamate (YKP509) as adjunctive treatment in reducing the number of drop seizures (tonic, atonic, and tonic-clonic) compared with placebo in pediatric and adult subjects (age 4-55 years) diagnosed with Lennox Gastaut Syndrome (LGS).

Начало: 28.04.2022 Край: 01.12.2028 Възраст: 4–55 г. Лечение

Argentina, Australia, Colombia +12 SK Life Science, Inc. NCT05219617

Набира участници Фаза 3

Effect of Testofen on Erectile Function in an Adult Male Population

Erectile Dysfunction

This is a double blind, randomised, placebo-controlled clinical study with a 12-week participation and 3 groups (2 active groups and 1 placebo group) designed to monitor erectile function symptom severity and the effect Testofen may have on improving erectile function, sexual function, and quality of life.

Начало: 19.04.2022 Край: 01.06.2026 Възраст: 40–75 г. Лечение

Australia RDC Clinical Pty Ltd NCT05232279

Набира участници Фаза 1/2

The Pediatric Acute Leukemia (PedAL) Screening Trial - A Study to Test Bone Marrow and Blood in Children With Leukemia That Has Come Back After Treatment or Is Difficult to Treat - A Leukemia & Lymphoma Society and Children's Oncology Group Study

Acute Lymphoblastic Leukemia Acute Myeloid Leukemia Acute Myeloid Leukemia Post Cytotoxic Therapy Juvenile Myelomonocytic Leukemia +4

This study aims to use clinical and biological characteristics of acute leukemias to screen for patient eligibility for available pediatric leukemia sub-trials. Testing bone marrow and blood from patients with leukemia that has come back after treatment or is difficult to treat may provide information about the patient's leukemia that is important when deciding how to best treat it, and may help doctors find better ways to diagnose and treat leukemia in children, adolescents, and young adults.

Начало: 18.04.2022 Край: 31.12.2030 Възраст: до 22 г. Скрининг

Australia, Canada, New Zealand +2 PedAL BCU, LLC NCT04726241

1 … 68 69 70 71 72 … 154