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Намерени 4,436 изпитвания Стр. 34 от 222

Recruiting Phase 1

A Study to Evaluate the Safety, Tolerability, Pharmacokinetics and Immunogenicity of Efimosfermin Alfa Administered as a Single Dose to Healthy Participants of Chinese, Japanese, and White/European Ancestry

Non-alcoholic Fatty Liver Disease

This is a first time in Asia (FTIA) study designed to evaluate the safety, tolerability, pharmacokinetic (PK) and immunogenicity of efimosfermin alfa to healthy participants of Chinese, Japanese, and White/European ancestry.

Начало: 05.03.2026 Край: 17.08.2026 Възраст: 18–55 г. Treatment

New Zealand GlaxoSmithKline NCT07335198

Recruiting Phase 1

A Phase 1 Study of GS101 Injection

Atopic Dermatitis (AD)

This is a randomized, double-blind, three-arm, parallel-group study designed to demonstrate the similarity of the pharmacokinetics (PK), safety, and immunogenicity of GS101 injection compared with U.S. commercial Dupixent® and CN commercial Dupixent® in healthy adult participants in China. A total of 294 healthy male adult participants, with 98 participants per treatment group across 3 groups.

Начало: 05.03.2026 Край: 01.09.2026 Възраст: 18–55 г.

China Jiangsu Genscend Biopharmaceutical Co., Ltd NCT07411755

Recruiting Phase 3

A Study to Evaluate the Efficacy and Safety of Standard-of-Care Chemotherapy and Bevacizumab With or Without INCA33890 in the First-Line Treatment of Metastatic Microsatellite Stable Colorectal Cancer

CRC (Colorectal Cancer)

The purpose of this study is to evaluate the efficacy and safety of standard-of-care chemotherapy and bevacizumab with or without INCA33890 in the first-line treatment of metastatic microsatellite stable colorectal cancer.

Начало: 05.03.2026 Край: 28.09.2029 Възраст: от 18 г. Treatment

Argentina, Australia, Belgium +16 Incyte Corporation NCT07284849

Recruiting Phase 2

A Trial to Evaluate Efficacy and Safety of Maridebart Cafraglutide in Adults Living With Elevated Liver Fat and Obesity or Overweight

Overweight or Obesity and Elevated Liver Fat

The main objective of this trial will be to determine whether maridebart cafraglutide is superior to placebo on reduction in liver fat content and body weight in participants living with obesity or overweight and elevated liver fat content, when administered in conjunction with reduced-calorie diet and increased physical activity.

Начало: 05.03.2026 Край: 22.12.2027 Възраст: 18–99 г.

United States Amgen NCT07441252

Recruiting

Diaphragmatic Training on GERD

GERD Diaphragmatic Training

he goal of this clinical trial is to evaluate the effects of diaphragm-oriented breathing training on patients with gastroesophageal reflux disease (GERD). This study will compare two non-invasive respiratory interventions-diaphragmatic breathing exercise (DBE) and volume-oriented incentive spirometry (VIS)-in terms of their impact on esophageal function and health-related quality of life.The main questions it aims to answer are:Does DBE or VIS improve GERD symptoms as measured by the GERD Questionnaire (GERDQ)?Do these interventions reduce esophageal acid exposure time and the number of reflux episodes?Do these interventions improve lower esophageal sphincter (LES) pressure and esophageal motility?Do these interventions improve GERD-related quality of life as measured by the GERD-HRQL questionnaire?Researchers will compare three groups: DBE, VIS, and a control group receiving standard care, to determine whether diaphragm-oriented breathing training provides additional benefits over usual management.Participants will:Be randomly assigned to one of three groups (DBE, VIS, or control)Perform the assigned intervention for 6 weeksUndergo baseline and post-intervention assessments, including symptom questionnaires and esophageal function testing Record symptoms and adherence in a daily diary

Начало: 04.03.2026 Край: 30.09.2028 Възраст: 20–80 г.

Taiwan Changhua Christian Hospital NCT07544433

Recruiting Phase 1

A Study to Evaluate Single and Multiple Doses of SEP-479 in Healthy Adult Participants

Healthy Volunteers

The purpose of this study is to evaluate the safety, tolerability, pharmacokinetics, pharmacodynamics, and food effects of oral SEP-479 in healthy adult participants.

Начало: 04.03.2026 Край: 01.02.2027 Възраст: 21–60 г. Treatment

Australia Septerna, Inc. NCT07433179

Recruiting Phase 2

Efficacy and Safety of KAI-9531 Administered Once Weekly in Participants Living With Obesity Who Do Not Have Diabetes

Obesity

The primary objective of this study is to determine the effects of KAI-9531 administered by subcutaneous (SC) injection once weekly compared to placebo on percent change in body weight.

Начало: 04.03.2026 Край: 01.06.2027 Възраст: от 18 г.

United States Kailera NCT07458269

Recruiting

Rezdiffra Pregnancy and Lactation Registry

MASH - Metabolic Dysfunction-Associated Steatohepatitis

To evaluate pregnancy and clinical outcomes in women with NASH and their infants after exposure to Rezdiffra at any time during pregnancy and/or lactation.

Начало: 04.03.2026 Край: 08.04.2030

United States Madrigal Pharmaceuticals, Inc. NCT07541469

Recruiting Phase 3

Postoperative Radiotherapy Combined With Nimotuzumab Followed by Benmelstobart in High-Risk Patients With Head and Neck Squamous Cell Carcinoma

Head & Neck Squamous Cell Carcinoma Head & Neck Cancer Postoperative Adjuvant Treatment

A Multicenter, Randomized, Controlled, Open-Label, Phase III Clinical Trial.To evaluate the efficacy and safety of postoperative radiotherapy combined with Nimotuzumab followed by Benmelstobart in high-risk patients with head and neck squamous cell carcinoma who are ineligible for cisplatin chemotherapy. The primary endpoint is disease-free survival (DFS). A total of 185 patients will be enrolled in both the study group and the control group, respectively, with a total planned enrollment of 370 patients. Enrollment is expected to be completed within 2 years, followed by a 3-year follow-up period after the last patient is enrolled.

Начало: 04.03.2026 Край: 05.03.2031 Възраст: от 18 г.

China Shanghai Ninth People's Hospital Affiliated to Shanghai NCT07445048

Recruiting

An Evaluation of the Safety and Tolerability of Ocular Lubricants

Dry Eye Disease

The purpose of this study is to evaluate the safety and tolerability of two new artificial tear formulations in subjects with moderate dry eye disease.

Начало: 04.03.2026 Край: 01.08.2026 Възраст: от 18 г. Treatment

Australia Alcon Research NCT07238699

Recruiting Phase 1

A Clinical Study of MK-4082 in Healthy Overweight Participants (MK-4082-002)

Healthy

Researchers are looking for new weight loss medicines for people with higher body weight. The study medicine, MK-4082, is different from similar weight loss medicines because people take it as a pill instead of an injection. Before giving a study medicine to people with a health condition, researchers first do studies to find a safe dose level (amount) of the study medicine that can be used in future studies. The goals of this study are to learn about: * The safety of MK-4082 and if people tolerate it * What happens to different MK-4082 dose levels in a person's body over time

Начало: 04.03.2026 Край: 19.08.2026 Възраст: 18–60 г.

United States Merck Sharp & Dohme LLC NCT07388667

Recruiting Phase 4

Intrathecal drug delivery systems versus comprehensive medical management for severe cancer pain: a randomized controlled trial

Severe refractory cancer pain

Trial status: Authorised Patient comfort is evaluated with the General Comfort Questionnaire (GCQ), a self-reported instrument consisting of 48 items that reflect the physical, spiritual, environmental, and social dimension., The survival rate in both groups, CMM and IDD, will be determined by recording the time from treatment initiation until death., Pain intensity will be measured with the VAS (ranging from 0 (no pain) to 100 (maximal pain)) in electronic format., Perceived stress will be assessed by using the 10-item Perceived Stress Scale (PSS; Cohen, Kamarch, & Mermelstein, 1983)., Patient anxiety will be provided through the State Trait Anxiety Inventory (STAI)., Using the Injustice Experience Questionnaire (IEQ), perceived injustice related to current health status will be assessed., The General Self-Efficacy (GSE) Scale is a 10-item self-report questionnaire used to assess perceived self-efficacy., To evaluate caregiver burden, the Zarit Burden Interview (ZBI) questionnaire will be completed., Expenditures related to in-hospital care will be extracted from hospital claims data. All other healthcare-related costs will be gathered through telephone interviews with patients, conducted each month after treatment initiation. During these calls, researchers will ask patients whether they have had any medical consultations, hospital admissions, AEs, changes in medication (daily morphine or MED), or incurred any additional healthcare costs., Safety, all (S)AEs will be documented throughout the duration of the study. HRQoL will be evaluated with the EORTC QLQ-C30 questionnaire.

Начало: 04.03.2026 Възраст: от 18 г.

Belgium Vrije Universiteit Brussel 2025-522381-68-00

Recruiting

The Real-World Control-IQ Glycemic Control and Quality of Life Study in Type 1 Diabetes in France

Diabetes Mellitus, Type 1

This post-market surveillance study is primarily designed to demonstrate the ongoing safety of the Control-IQ system, the ongoing performance of glycemic control and quality of life with Control-IQ system use, and the rate of use of the Control-IQ system. The system will be assessed in all approved populations during the first 12 months of use.

Начало: 03.03.2026 Край: 01.12.2027 Възраст: от 6 г.

France Tandem Diabetes Care, Inc. NCT07211126

Recruiting Phase 1

A Study of DXC014 in Patients With Advanced Solid Tumors.

Small Cell Lung Cancer Melanoma Prostate Cancer Other Advanced Solid Tumors

This is a phase I, open-label, first-in-human clinical study designed to evaluate the safety, tolerability, MTD, DLT, RP2D, the PK characteristics, preliminary anti-tumor activity, the immunogenicity of DXC014 in patients with Advanced Solid Tumors.

Начало: 03.03.2026 Край: 20.10.2030 Възраст: от 18 г.

China Hangzhou DAC Biotechnology Co., Ltd. NCT07177937

Recruiting Phase 2

Tamoxifen and Pegylated Liposomal Doxorubicin for the Treatment of Patients With Metastatic or Inoperable, Locally Advanced Triple Negative Breast Cancer

Anatomic Stage III Breast Cancer AJCC v8 Anatomic Stage IV Breast Cancer AJCC v8 Locally Advanced Unresectable Triple-Negative Breast Carcinoma Metastatic Triple-Negative Breast Carcinoma

This phase II trial tests how well tamoxifen and pegylated liposomal doxorubicin works in treating patients with triple negative breast cancer that has spread from where it first started (primary site) to other places in the body (metastatic) or that has spread to nearby tissue or lymph nodes (locally advanced) and is unable to be operated on (inoperable). Tamoxifen works by blocking the effects of estrogen in the breast. This may help stop the growth of tumor cells that need estrogen to grow. Doxorubicin is in a class of medications called anthracyclines. Doxorubicin damages the cell's DNA and may kill cancer cells. It also blocks a certain enzyme needed for cell division and DNA repair. Liposomal doxorubicin is a form of the anticancer drug doxorubicin that is contained inside very tiny, fat-like particles. Liposomal doxorubicin may have fewer side effects and work better than other forms of the drug. Giving tamoxifen and pegylated liposomal doxorubicin together may work better in treating patients with metastatic or inoperable, locally advanced triple negative breast cancer than giving either of these drugs alone.

Начало: 03.03.2026 Край: 30.11.2028 Възраст: от 18 г.

United States Roswell Park Cancer Institute NCT06434064

Recruiting

Randomized Controlled Trial of Two Mobile Health Strategies to Manage Postpartum Hypertension

Hypertension, Pregnancy Induced

A multicenter randomized trial that will compare the effectiveness of two postpartum blood pressure (BP) management strategies in improving blood pressure and cardiac function and increasing patient engagement and feeling of control over one's health

Начало: 02.03.2026 Край: 01.11.2029 Възраст: от 18 г.

United States Jennifer Lewey, MD, MPH NCT07209254

Recruiting Phase 1

A Study to Evaluate ALN-4915 in Adult Healthy Volunteers

Healthy Volunteers

The purpose of this study is to evaluate the safety, tolerability, pharmacodynamics (PD) and pharmacokinetics (PK) of ALN-4915.

Начало: 02.03.2026 Край: 31.07.2027 Възраст: 18–65 г.

United Kingdom Alnylam Pharmaceuticals NCT07535606

Recruiting

CHOICE:Decision Factor of EGFR-TKI in Chinese IV NSCLC

Non-Small Cell Lung Cancer

This non-interventional, cross-sectional study aims to investigate treatment preferences from a sample of physicians and patients with experience of 1L EGFR-TKI for stage IV NSCLC by administering a survey, which primarily includes a DCE approach.

Начало: 02.03.2026 Край: 31.07.2026 Възраст: от 18 г.

China AstraZeneca NCT07413757

Recruiting

Auricular Acupuncture on Emotional Distress in Service Members and Veterans With PTSD

PTSD and Substance Use Disorder Emotional Distress

Emotional distress (ED) refers to a state of mental suffering that significantly impairs an individual's ability to cope, often leading to a decline in overall well-being. In military contexts, ED is a prevalent concern due to the unique and demanding challenges faced by military personnel both in combat zones and during peacetime. The primary objective of this study is to assess the efficacy of integrating ear acupuncture with mindfulness therapy in mitigating ED and alleviating post-traumatic stress disorder (PTSD) symptoms among military personnel. The study will examine the effects of auricular acupuncture (AA) and mindfulness therapy (MT) on ED in military personnel with PTSD. The NADA ear acupuncture protocol will be administered using acupuncture semi-permanent (ASP), sterile needles placed in the bilateral ears, which will remain in place until they naturally fall out. Mindfulness therapy will incorporate relaxation techniques, such as yoga and controlled breathing exercises, specifically designed to alleviate ED. A mixed-methods approach, integrating both quantitative and qualitative methods, will be employed concurrently to evaluate the interventions' effectiveness and to explore the participants' perceived benefits. Specific Aim 1: To evaluate the effectiveness and perceived benefits of the National Acupuncture Detoxification Association (NADA) ear acupuncture protocol as an adjunct therapy to brief mindfulness therapy for reducing emotional distress in service members and veterans with PTSD. Specific Aim 2: To examine the effectiveness of NADA as an adjunct therapy to brief mindfulness therapy in improving sleep disturbances, alcohol use, and pain in service members and veterans with PTSD.

Начало: 02.03.2026 Край: 01.06.2028 Възраст: 18–65 г.

United States United States Naval Medical Center, San Diego NCT07021352

Recruiting Phase 1

Dual-Targeting CAR-NK Cells for Recurrent/Progressive Glioblastoma and High-Grade Glioma

Malignant Glioma High-Grade Gliomas Glioblastoma Recurrent High-Grade Gliomas +1

This is a draft, ClinicalTrials.gov-style example record for a first-in-human Phase 1 study evaluating locoregional administration of dual-targeting chimeric antigen receptor natural killer (CAR-NK) cells in adults with recurrent or progressive glioblastoma (GBM) or other high-grade glioma (HGG). Participants will undergo tumor antigen profiling for IL13Rα2, EGFR/EGFRvIII, and B7-H3 (CD276). Based on this assessment, each participant will receive the most suitable dual-target CAR construct to reduce antigen-escape risk.

Начало: 02.03.2026 Край: 17.04.2028 Възраст: 18–75 г.

China Beijing Biotech NCT07551336

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