Търсене на изпитвания

Намерени 4,436 изпитвания Стр. 20 от 222

Набира участници

Change in IOP Fluctuation After DSLT

Glaucoma

This is a prospective, single-center, single-arm, observational study designed to evaluate the change in diurnal intraocular pressure (IOP) fluctuation following Direct Selective Laser Trabeculoplasty (DSLT) in patients with primary open-angle glaucoma (POAG) who are on 1-3 IOP lowering medications. The study will be conducted at one site and will involve three key visits: a screening visit, a baseline/treatment visit, and a 6-month follow-up visit. During the screening visit, patients will undergo a comprehensive ophthalmic examination, and eligibility will be confirmed. The eye with the higher IOP will be selected if both eyes are eligible. At the baseline visit, diurnal IOP will be recorded at three time points (9am, 12pm, and 4pm) before DSLT is performed. The primary endpoint is the change in diurnal IOP fluctuation 6 months post-treatment. Secondary endpoints include changes in mean diurnal IOP and the proportion of eyes achieving a reduction in IOP fluctuations of ≥1 mmHg. Exploratory endpoints focus on demographic variables associated with IOP fluctuation changes.

Начало: 02.04.2026 Край: 03.04.2027 Възраст: от 18 г.

United States Ophthalmology Associates, Fort Worth NCT07428668

Набира участници Фаза 3

An Evaluation of the Safety and Efficacy of TSND-201 for the Treatment of PTSD (EMPOWER-1)

Post Traumatic Stress Disorder

This study is evaluating the safety and efficacy of TSND-201 in adults with PTSD. Eligible participants will enter a 4-week Treatment Period where they will be randomized 1:1:1 to receive one of two doses of TSND-201 or placebo, once per week. Following the Treatment Period, participants will enter an 8-week Follow-up Period.

Начало: 02.04.2026 Край: 01.12.2027 Възраст: от 18 г.

United States Transcend Therapeutics NCT07456696

Набира участници Фаза 3

Efficacy and Safety of Minocycline in Acute Spontaneous Intracerebral Hemorrhage

Intracerebral Hemorrhage

This is a prospective, multicenter, randomized, double-blind, placebo-controlled clinical trial. It aims to evaluate the efficacy and safety of oral minocycline in patients with acute spontaneous intracerebral hemorrhage within 48 hours of onset.

Начало: 02.04.2026 Край: 01.12.2028 Възраст: 18–80 г.

China Beijing Tiantan Hospital NCT07338175

Набира участници Фаза 2

Evaluating NALIRIFOX vs Modified Gemcitabine, Nab-Paclitaxel and Cisplatin in Patients With Locally Advanced and Metastatic Pancreatic Adenocarcinoma

Metastatic Pancreatic Adenocarcinoma Locally Advanced Pancreatic Adenocarcinoma

This is a single-center, open-label, randomized Phase 2 trial to evaluate the efficacy of NALIRIFOX (Arm 1) vs mGAP (Arm 2) in previously untreated patients with locally advanced (unresectable) and metastatic pancreatic ductal adenocarcinoma (PDAC).

Начало: 02.04.2026 Край: 01.11.2029 Възраст: от 18 г.

United States Medical University of South Carolina NCT07076212

Набира участници Фаза 3

EVALUATING THE EFFICACY AND SAFETY OF MET097, A FULLY- BIASED ULTRA LONG-ACTING GLP-1RA IN PEOPLE WITH OVERWEIGHT OR OBESITY: A PHASE 3, MULTI-CENTER RANDOMIZED, CONTROLLED TRIAL (VESPER-4)

Obesity

Trial status: Authorised Change from baseline in body weight (kg) at Week 64, Occurrence at Week 64 of: • CCI % of reduction from baseline body weight • CCI% of reduction from baseline body weight • CCI % of reduction from baseline body weight • O CCI % of reduction from baseline body weight, Change from baseline at Week 64 in: • Fasting triglycerides (mg/dL) • O Non-high-density lipoprotein-cholesterol (non-HDL-C) (mg/dL), Change from baseline in SBP (mmHg) at Week 64, Change from baseline in Short Form 36 health survey (SF-36) physical function domain score at Week 64, Percent change from baseline in body weight at Week 84, Change from baseline in body weight (kg) at Week 84 Percent change from baseline in body weight at Week 64

Начало: 02.04.2026 Възраст: от 18 г.

Bulgaria, Czech Republic, Germany +5 Metsera Inc. 2025-523974-18-00

Набира участници Фаза 4

Effect of ZaStaprazan on Platelet Reactivity of Clopidogrel After PercuTaneous CoronAry InteRvention

Chronic Coronary Syndrome

The purpose of this study is to evaluate the clinical utility of zastaprazan compared to proton pump inhibitors (PPIs) in patients receiving dual antiplatelet therapy (DAPT) including clopidogrel after percutaneous coronary intervention (PCI), by comparing their effects on platelet reactivity.

Начало: 02.04.2026 Край: 12.07.2028 Възраст: от 19 г.

South Korea Yonsei University NCT07471867

Набира участници Фаза 1/2

ASCEND: Safety and Tolerability of ION337 for the Treatment of Dravet Syndrome

Dravet Syndrome

The primary purpose of this study is to evaluate the safety and tolerability of ION337 in participants with Dravet syndrome (DS).

Начало: 01.04.2026 Край: 01.12.2030 Възраст: 2–12 г.

United States Ionis Pharmaceuticals, Inc. NCT07531745

Набира участници

Observational Study to Investigate the Short-term Effects of Transcorneal Electrical Stimulation on Visual Performance

Retinitis Pigmentosa (RP) Usher Syndrome Cone Rod Dystrophy

Retinitis pigmentosa and similar degenerative diseases of the retina lead to progressive loss of vision. TES therapy with the CE-marked OkuStim® System is a treatment approved in the EU for slowing the progression of the disease. Patients increasingly report short-term subjective improvements in vision, which have not yet been systematically investigated. This exploratory study is conducted to determine whether these subjective short-term effects can be measured, and therefore also be quantified, by objective tests.

Начало: 01.04.2026 Край: 01.03.2027 Възраст: от 18 г.

Germany Okuvision GmbH NCT07548944

Набира участници Фаза 2/3

Study to Evaluate the Efficacy and Safety of BMN 333 Versus Vosoritide in Children With Achondroplasia

Achondroplasia

This is a multicenter, multinational, randomized, active-controlled, operationally seamless Phase 2/3 study of BMN 333 in treatment-naïve pediatric participants with achondroplasia (ACH). The study consists of a Phase 2 part and a Phase 3 part.

Начало: 01.04.2026 Край: 01.09.2029 Възраст: 2–17 г.

United States BioMarin Pharmaceutical NCT07441876

Набира участници Фаза 3

Suzetrigine for Treatment and Reduction of Intense Discomfort After knEe Replacement PAIN

Total Knee Replacement Surgery Post-operative Pain

This is a prospective, randomized study. The purpose of this study is to evaluate if the addition of Suzetrigine, a new pain medication, to well established peri-operative pain regimen used for total knee replacement surgery will effect pain control. 1. Does Suzetrigine given pre-operatively decrease the total opioid consumed after total knee replacement surgery? 2. Dose Suzetrigine given pre-operatively decrease the visual analog pain scale pain scores after total knee replacement surgery? Study participants will be randomly assigned to receive either Suzetrigine medication or placebo medication.

Начало: 01.04.2026 Край: 23.02.2027 Възраст: 18–85 г.

United States Icahn School of Medicine at Mount Sinai NCT07548385

Набира участници Фаза 1

A Study to Investigate the Safety, Tolerability, Pharmacokinetics, and Pharmacodynamics of Single and Multiple Doses of EDP-978 in Healthy Adults

Chronic Inducible Urticaria Chronic Spontaneous Urticaria

This study is a randomized, double-blind, sponsor-open, placebo-controlled study. It will assess the safety, tolerability, pharmacokinetics and pharmacodynamics of orally administered single and multiple doses of EDP-978 in healthy adult subjects.

Начало: 01.04.2026 Край: 01.11.2026 Възраст: 18–65 г.

United States Enanta Pharmaceuticals, Inc NCT07540910

Набира участници

Improving Cognitive Rehabilitation Outcomes

Mild Traumatic Brain Injury Posttraumatic Stress Disorder

Posttraumatic stress disorder (PTSD) and mild TBI (mTBI) frequently co-occur in post-9/11 Veterans, and together are associated with worse cognitive performance, mental health, everyday functioning, community integration, quality of life, and treatment response than either condition alone. Additional comorbidities, such as depression and sleep disturbance, are common and further exacerbate these problems. The investigators will investigate Compensatory Cognitive Training (CCT) and Morning Bright Light Therapy (MBLT) vs Negative Ion Generator (ION), to directly target cognition, depression, and sleep disturbance and to improve CCT-associated rehabilitation outcomes. The investigator's randomized controlled trial in 144 Veterans with mTBI+PTSD across two VA sites will compare cognition, functioning, and other secondary outcomes following CCT+MBLT vs. CCT+ION. This study addresses the significant gap in services and evidence-based treatments for Veterans with mTBI+PTSD.

Начало: 01.04.2026 Край: 30.09.2030 Възраст: от 18 г.

United States VA Office of Research and Development NCT07055633

Набира участници

Guided Needle Insertion for Vascular Access

End Stage Renal Failure, Hemodialysis Cannulation

The goal of this clinical trial is to determine whether the study device can assist the cannulator with placing two needles during cannulation required to initiate dialysis treatment. Males or females with end-stage kidney disease who are 18 and older and not pregnant or breastfeeding can be included in the study. The main question it aims to answer is: Can the study device guide the cannulator to the arteriovenous fistula (AVF) or arteriovenous graft (AVG) and assist the cannulator with needle insertion into the AVF or AVG for dialysis cannulation?

Начало: 01.04.2026 Край: 01.05.2026 Възраст: от 18 г.

Uzbekistan X9, Inc. NCT07548151

Набира участници

Taking Measurements of a Gum Graft Site as it Heals

Gingival Recession

This is an observational study. The participants in this study will be patients at the Graduate Periodontics Clinic at The Ohio State University who are planning to get a gingival graft to treat their gum recession. Gingival grafts are a common way to treat this recession. The grafting surgery is not part of the study. The main purpose of this study is to better understand the normal healing of a gum graft. In order to do that, the investigators will take different kinds of measurements. 1. It is common for the tissue around the graft to have some swelling after the surgery. The investigators will measure the amount of swelling at different times as the graft heals. This will be done with a digital scanner which is passed over the area. 2. A device which measures blood flow will be used to see how new blood vessels are forming. This is also a device which is only passed over the area, so it is not invasive. 3. Saliva samples will be taken from around the teeth using sterile paper strips. This fluid will be analyzed for substances related to wound healing. 4. Participants will fill out questionnaires about their experience with the graft healing.

Начало: 01.04.2026 Край: 01.05.2027 Възраст: 18–50 г.

United States Ohio State University NCT07386457

Набира участници

Effect of Daily Humiome® Post LB Intake on Wellbeing in Older Individuals With Moderate Stress Levels

Stress

The placebo-controlled, double blind parallel intervention trial "PostWelLB" aims to test whether 3 months of daily supplementation with the postbiotic product "Humiome® Post LB" (HPLB; 340 mg / day) can reduce self-reported stress (PSS10 questionnaire)- in an older (50 - 75 years; all genders) population in France.

Начало: 01.04.2026 Край: 01.12.2026 Възраст: 50–75 г.

France dsm-firmenich Switzerland AG NCT07471659

Набира участници Фаза 1

A Study Evaluating the Safety and Tolerability of Artesunate in Patients With Pulmonary Arterial Hypertension

Pulmonary Arterial Hypertension (PAH)

This is a 20-week, Phase 1, single-center, open-label, dose-escalation study evaluating the safety and tolerability of daily oral artesunate in patients with PAH.

Начало: 01.04.2026 Край: 01.01.2029 Възраст: 18–60 г.

United States Joseph C. Wu NCT06872112

Набира участници

Health Promotion With Targeted Exercise Intervention for Decreasing Fall Risk and Inactivity in Aging Veterans With Obesity and Signs of Sarcopenia

Falls Sarcopenia Obesity

Falls are a major health risk for older Veterans, especially those with both obesity and low muscle mass or strength (sarcopenia), which together increase the chances of falling and losing independence. Many older Veterans have difficulty staying active and often lack information about how to safely exercise. While current guidelines focus mostly on weight loss, losing weight alone can weaken muscles and bones, which may actually raise the risk of falls and injuries. This study is testing the benefits of a virtual group exercise program combined with health education. The goal is to find out if exercise combined with health education is better at lowering fall risk and improving daily activity than health education alone for Veterans with obesity and signs of sarcopenia.

Начало: 01.04.2026 Край: 30.05.2031 Възраст: от 55 г.

United States VA Office of Research and Development NCT07206368

Набира участници

Nanochon Chondrograft First in Human (FIH) Early Feasibility Study (EFS) - Canada

Knee Cartilage Lesions

The goal of this First in Human study is to learn if the Nanochon Chondrograft Implant is a safe primary surgical treatment for participants with cartilage lesions in the knee. This study will include males and females between the ages of 22 and 60.

Начало: 01.04.2026 Край: 01.08.2027 Възраст: 22–60 г.

Canada Nanochon, Inc. NCT07249489

Набира участници Фаза 1/2

Biomarker-based Trial of NPC-1 for Alzheimer's Pathology

Alzheimer Disease Mild Cognitive Impairment (MCI) Subjective Cognitive Complaints (SCCs)

The goal of this early phase, open-label, single arm clinical trial is to determine the 6-month effects and tolerability of NPC1 (parthenolide and ipriflavone) on biomarkers of Alzheimer's Disease among adults with objective indicators of seeding AD pathology that also have subjective cognitive concerns, Mild Cognitive Impairment, or Alzheimer's Disease (AD)

Начало: 01.04.2026 Край: 01.06.2027 Възраст: от 55 г.

United States Massachusetts General Hospital NCT07236190

Набира участници Фаза 3

Suzetrigine-enhanced MultimOdal Opioid-sparing THerapy in Cardiac and Bariatric SURGery

Bariatric Surgery Cardiac Surgery With Sternotomy Post-operative Pain

This is prospective, randomized study. The purpose of this study is to evaluate whether the addition of Suzetrigine to well established multimodal pain regimen for participants undergoing bariatric patients undergoing weight-loss surgery and cardiac patients undergoing sternotomy will reduce post-operative opioid consumption and pain scores.

Начало: 01.04.2026 Край: 22.12.2026 Възраст: 18–85 г.

United States Icahn School of Medicine at Mount Sinai NCT07539623

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