Search trials – HealthDB

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Намерени 4,781 изпитвания Стр. 191 от 240

Not yet recruiting

Food Trial Evaluating Fecal Abundance of SBD111 With Once-Daily Versus Twice-Daily Administration in Healthy Adults

Osteopenia Osteoporosis Menopause Related Conditions Probiotic Intervention +1

The purpose of this study is to determine whether a modified formulation and daily intake schedule of SBD111 results in similar levels of probiotic microbes in the gut compared with the currently used formulation. SBD111 is a food made of probiotic microbes (bacteria and yeast) and prebiotic dietary fibers (a form of fiber obtained from diet). SBD111 is a medical food used for the dietary management of postmenopausal bone loss.SBD111 was previously found to be safe and well tolerated in a human clinical safety study and a clinical efficacy study. Study participation will include a screening virtual visit, periodic remote questionnaires and check-in calls, and three at-home stool swab sample collections. Eligible participants will be assigned to one of two SBD111 study groups evaluating different formulations and dosing schedules. Each day for a 28-day period, they will take (i) two capsules once daily or (ii) two capsules twice daily (morning and evening), depending on the study group assigned. Investigators will collect demographic information and will ask questions related to dietary intake, bowel habits, and health history. Upon enrollment into the study, participants will receive six at-home stool sample collection kits, two each for baseline, Week 1, and Week 4 analysis. Samples will be collected at home and mailed to a Sōlaria Biō for analysis of the bacterial community that lives in the intestine (the gut microbiome). During the study, participants will also be asked to complete brief questionnaires related to gastrointestinal symptoms, cognitive function, well-being, and sleep. On days 7 and 28 of the study, they will be asked to complete a brief adherence questionnaire and discuss any adverse (negative) events. All participants will receive compensation in the form of gift cards for completing study procedures and returning stool samples. Participants will receive a $50.00 gift card after completing the Week 1 study procedures and after receipt of the mailed baseline and Day 7 stool swab samples. Participants will receive a $150.00 gift card after completing the Week 4 study procedures and after receipt of the mailed Week 4 stool swab sample.

Начало: 01.04.2026 Край: 01.02.2027 Възраст: от 35 г.

Solarea Bio, Inc NCT07538167

Not yet recruiting Early Phase 1

The Safety, Dosimetry and Efficacy of 177Lu-FC516 in Patients With Prostate Cancer

Prostate Cancer

This study is a prospective, single-arm, open-label, dose-escalation study. A total of 5 dose groups were pre-defined in this study. The drug was administered once every 6 weeks.The drug would be administered for 1 to 4 cycles. After each dose group completed the enrollment and DLT observation, based on the participant's safety tolerance, radiation dosimetry, and preliminary efficacy evaluation results, it was decided whether to adjust the dose of the subsequent dose groups or to suspend the dose escalation.

Начало: 01.04.2026 Край: 01.10.2027 Възраст: от 18 г.

China FindCure Biosciences (ZhongShan) Co., Ltd. NCT07542379

Not yet recruiting

The Role of Potassium Channels in Working Memory Impairments of Chronic Cocaine Users

Cocaine Use Disorder (CUD) Cognitive Impairments

The study aims to address the neurobiological basis of cognitive impairments in chronic cocaine users by investigating the potential impact of an acute potassium channel blockade on working memory performance and other cognitive functions.

Начало: 01.04.2026 Край: 01.08.2027 Възраст: 20–50 г.

Switzerland Boris Quednow NCT07532460

Not yet recruiting

Effect of Inspiratory Muscle Training on Diaphragm Function in COPD Patients

Chronic Obstructive Pulmonary Disease (COPD) Diaphragm Dysfunction

This study investigates the effect of threshold inspiratory muscle training on diaphragm thickness and diaphragm excursion, measured using ultrasonography, in patients with stable chronic obstructive pulmonary disease (COPD).

Начало: 01.04.2026 Край: 01.09.2026 Възраст: 40–59 г.

Universitas Padjadjaran NCT07539974

Not yet recruiting

A Case-Control Observational Study of Peripheral Blood-Derived iPSC Models to Investigate Oligodendrocyte Lineage Development in Children With Williams Syndrome and Healthy Controls

Williams Syndrome Induced Pluripotent Stem Cell (Ips Cell)

This study aims to collect peripheral blood samples from children with Williams syndrome (WS) and healthy children, establish a cell line of induced pluripotent stem cells (iPSCs) derived from the subjects, and further induce and differentiate them into neural progenitor cells (NPCs) and oligodendrocyte lineage cells for in vitro studies on the cellular and molecular mechanisms of WS-related neurodevelopmental abnormalities. Based on previous basic and pre-experimental results, the study focuses on the developmental transition of oligodendrocyte lineage from OPC to pre-OL, immature oligodendrocytes, and mature oligodendrocytes, and specifically evaluates the programs of myelin-related genes, differentiation trajectories, and abnormalities in related pathways such as GTF2I/FZD9, ERK/MAPK, and Wnt/β-catenin. The study design is an independent donor case-control study, and it plans to include 3 children with WS and 3 healthy children. Each sample will be independently sequenced.

Начало: 01.04.2026 Край: 01.01.2027 Възраст: 3–12 г.

Qilu Hospital of Shandong University NCT07537374

Not yet recruiting Phase 3

A Multicenter, Randomized, Double-Blind, Placebo-Controlled Phase III Clinical Study to Evaluate the Efficacy and Safety of RSS0393 Ointment in Adult Patients With Plaque Psoriasis.

Plaque Psoriasis Subjects

Phase III Efficacy and Safety Study of RSS0393 Ointment in Plaque Psoriasis.

Начало: 01.04.2026 Край: 01.12.2027 Възраст: от 18 г.

China Reistone Biopharma Company Limited NCT07543224

Not yet recruiting Phase 2

Efficacy and Safety of Sertraline Combined With Lactobacillus Crispatus in Adolescents With Depression : A Multicenter Randomized Controlled Trial

Major Depressive Disorder (MDD) Probiotic Intervention

The goal of this clinical trial is to evaluate the efficacy and safety of sertraline combined with Lactobacillus crispatus in adolescents aged 12-18 years with major depressive disorder. The main question it aims to answer is: Whether sertraline combined with Lactobacillus crispatus is superior to sertraline combined with placebo in reducing depressive symptoms and improving emotional symptoms in adolescents with depression. If there is a comparison group: Researchers will compare sertraline combined with Lactobacillus crispatus with sertraline combined with placebo ( look-alike substance that contains no probiotics) to determine whether the addition of Lactobacillus crispatus provides greater therapeutic benefit in adolescents with depression. Participants will: 1. Receive sertraline combined with Lactobacillus crispatus or sertraline combined with placebo for 8 weeks; 2. Attend clinic visits every 4 weeks for clinical assessments and safety monitoring

Начало: 01.04.2026 Край: 01.04.2028 Възраст: 12–18 г.

China First Affiliated Hospital of Chongqing Medical Universi NCT07539805

Not yet recruiting

Extended Time Window Intravenous Tenecteplase Thrombolysis Registry for Acute Ischemic Stroke

Stroke Acute Ischemic Stroke

The EXTEND-TNK Registry is a prospective, multicenter, observational cohort study designed to evaluate the effectiveness and safety of intravenous tenecteplase administered beyond 4.5 hours after last known well in patients with acute ischemic stroke (AIS) in routine clinical practice across China.

Начало: 01.04.2026 Край: 01.12.2029 Възраст: от 18 г.

China Sun Yat-Sen Memorial Hospital of Sun Yat-Sen University NCT07536165

Not yet recruiting

Comparison of the Effects of External Oblique Intercostal Plane Block and Subcostal Transversus Plane Block Methods With Ultrasound Guidance on Postoperative Analgesia in Laparoscopic Sleeve Gastrectomy Operations

Sleeve Gastrectomy External Oblique Intercostal Plane Block Subcostal Transverse Abdominis Plane Block

The primary aim of this study was to investigate the effects of the external oblique intercostal plane block and the subcostal transversus abdominis plane block on postoperative pain scores and opioid consumption in patients undergoing laparoscopic sleeve gastrectomy.

Начало: 01.04.2026 Край: 01.05.2027 Възраст: 18–65 г.

Turkey (Türkiye) Sanliurfa Education and Research Hospital NCT07547280

Not yet recruiting Phase 2

Peiyuan Guben Tongluo Ointment for Elderly Sarcopenia

Sarcopenia in Elderly

With the agarose concentrating group of Peiyuan Guben Tongluo Ointment set as the parallel control and an external control established simultaneously, this study aimed to evaluate the increases from baseline in DXA-measured limb muscle mass after 12 weeks of medication in elderly sarcopenia patients treated with the Ejiao concentrating group of Peiyuan Guben Tongluo Ointment.

Начало: 01.04.2026 Край: 31.12.2028 Възраст: 60–80 г.

China Shanghai Yueyang Integrated Medicine Hospital NCT07538674

Not yet recruiting Phase 1

Pharmacokinetics and Safety of GH001 Delivered Via a GH001 Aerosol Delivery System in Healthy Subjects

Healthy Adult

The primary objectives of this trial are to determine the pharmacokinetic (PK) profile and the safety and tolerability of GH001 delivered via a proprietary aerosol delivery device in healthy subjects after single-dose administration.

Начало: 01.04.2026 Край: 01.05.2026 Възраст: 21–64 г.

United States GH Research Ireland Limited NCT07540494

Not yet recruiting

Effect of Intravenous Ketamine Combined With Spinal Anesthesia on Sensory Block Duration Compared to Spinal Anesthesia Alone in Lower Limb Surgeries in Geriatrics.

IV Ketamine With Spinal Block

Effect of Intravenous Ketamine combined with Spinal Anesthesia on Sensory Block Duration compared to Spinal Anesthesia alone in Lower Limb surgeries in geriatrics:

Начало: 01.04.2026 Край: 01.08.2026 Възраст: от 65 г.

Cairo University NCT07520487

Not yet recruiting Phase 2

A Study of LY4395089 and Mirikizumab (LY3074828) Given Together and Mirikizumab (Alone) in Adults With Crohn's Disease

Crohn Disease

The main purpose of this study is to see how the safety and efficacy of a farnesoid X receptor (FXR) agonist (LY4395089), given together with mirikizumab compares with mirikizumab (alone) in adults with moderately to severely active Crohn's disease (CD). This study is part of the IIBD master protocol and will last approximately 62 weeks.

Начало: 01.04.2026 Край: 01.03.2028 Възраст: 18–80 г.

Belgium, Brazil, Canada +7 Eli Lilly and Company NCT07483099

Not yet recruiting Phase 3

PREcision MEDicine In Achalasia (PREMEDIA)

Type I Achalasia Type II Achalasia EGJ Outflow Obstruction Without Spastic/Hypercontractile Features

The goal of this clinical trial is to learn if shorter Per-Oral Endoscopic Myotomy (POEM) works as well as a longer POEM in patients with trouble swallowing due to certain conditions. The main question\[s\] it aims to answer \[is/are\]: * Does making a smaller cut in the muscle at the bottom of the esophagus work just as well as making the standard bigger cut in relieving symptoms? * Does making the smaller cut reduce the side effects of the procedure compared to the standard bigger cut? Researchers will compare the symptoms and side effects of making a shorter cut to the symptoms and side effects of a longer cut. Participants will allow researchers to access their standard of care information in their medical record, complete questionnaires at up to 6 times over a 2-year period.

Начало: 01.04.2026 Край: 01.03.2030 Възраст: от 18 г.

United States Northwestern University NCT07293650

Not yet recruiting Phase 3

Enarodustat + CsA vs CsA in Newly Diagnosed TD-NSAA

Transfusion-dependent Non-severe Aplastic Anemia

This study aimed to compare the efficacy and safety of enarodustat combined with cyclosporine versus cyclosporine monotherapy in the treatment of newly-diagnosed tansfusion-dependent non-severe aplastic anemia (TD-NSAA).

Начало: 01.04.2026 Край: 01.12.2029 Възраст: от 18 г.

Peking Union Medical College Hospital NCT07548671

Not yet recruiting Phase 2/3

A Study of BEBT-209 Plus Chemotherapy in Patients With Locally Advanced or Metastatic Triple-Negative Breast Cancer

Locally Advanced Triple-negative Breast Cancer Metastatic Triple-negative Breast Cancer

Title: A Study to See if BEBT-209 Combined With Chemotherapy Works to Treat People With Triple-Negative Breast Cancer Researchers want to learn if a new drug called BEBT-209 works to treat people with a specific type of breast cancer. This cancer is called locally advanced or metastatic triple-negative breast cancer (TNBC). The study has two parts. In the first part, researchers want to see if the new drug combination can shrink tumors. In the second part, researchers want to see if this treatment helps people live longer. Researchers will put participants into two groups by chance. This is like flipping a coin. Group 1: Participants get BEBT-209 plus two chemotherapy drugs. These drugs are Carboplatin and Gemcitabine. Group 2: Participants get only the two chemotherapy drugs. Researchers will group people based on the treatments they had in the past. Researchers will also check: How long the treatment keeps the cancer from growing. This is called progression-free survival (PFS). If the treatment is safe. Researchers will look for adverse events (AE), such as low blood cell counts. How participants feel. This is called health-related quality of life (HRQoL). How the body uses the drug.

Начало: 01.04.2026 Край: 01.12.2030 Възраст: 18–75 г.

China BeBetter Med Inc NCT07544056

Not yet recruiting

A Toolkit to Improve Mental Health Treatment for Autistic Individuals

Autism Mental Health Conditions

This pilot study is funded by the Organization for Autism Research (OAR). We are conducting a pilot study to improve mental health treatment for autistic individuals. First, we will conduct remote focus groups to identify barriers to mental health treatment and methods to improve treatment. Based on results, we will develop a prototype of a resource for therapists. This resource will be pilot tested in a community clinic.

Начало: 01.04.2026 Край: 01.12.2027 Възраст: от 13 г.

United States Florida International University NCT07539519

Not yet recruiting

STRIDE: Supporting Early Diabetes Self-Management for Parents

Diabetes Mellitus Type 2

This study will test STRIDE (SupporTing paRents with DiabEtes), a virtually delivered program that helps adults ages 21-44 who were recently diagnosed with type 2 diabetes and are caring for a child ages 2-14 within Kaiser Permanente Northern California. STRIDE focuses on practical skills for everyday life, with sessions on Prioritizing Self-Care, Eating Well Together, and Getting Active as a Family.

Начало: 01.04.2026 Край: 01.12.2027 Възраст: 21–44 г.

United States Kaiser Permanente NCT07544407

Not yet recruiting

Biofilm-induced Antimicrobial Resistance RIsk ERadication in Critical Care Central Venous Catheters

Catheter-Related Infections Biofilms Infection Prevention

Central venous catheter (CVC) infections are a frequent and serious nosocomial complication in critical care, leading to increased morbidity, mortality, and costs. The pathophysiology of these infections relies on the formation of a biofilm, an organized microbial structure that confers exceptional tolerance to anti-infectives and the immune system. However, data concerning the characteristics of the in vivo biofilm (kinetics, composition, endo- vs. extraluminal organization) on central venous catheters in intensive care patients are very limited, hindering the development of effective and targeted prevention strategies. The main aim of this study is to quantify the density and describe the spatial distribution (extra- and intraluminal compartments) of the biofilm on infected or colonized central venous catheters, prospectively collected from patients in the critical care units.

Начало: 01.04.2026 Край: 01.04.2028 Възраст: от 18 г.

France Centre Hospitalier Universitaire de Nīmes NCT07546994

Not yet recruiting

The Mepilex Cesarean Delivery Trial

Surgical Site Infection Following Cesarean Delivery

The goal of this clinical trial is to learn whether using a silver-containing antimicrobial foam dressing (Mepilex Ag) can help prevent surgical site infections in patients undergoing cesarean delivery. The main questions it aims to answer are: 1. Does Mepilex Ag reduce the rate of surgical site infections after cesarean delivery? 2. Is Mepilex Ag more effective than standard wound dressings in preventing infection? Researchers will compare those who receive the Mepilex Ag dressing to those who receive the standard dressing to see if the silver impregnated antimicrobial foam dressing lowers infection rate. Participants will: 1. Undergo a routine cesarean delivery as per usual obstetric indication 2. Be randomly assigned to receive either a silver-containing foam dressing or a standard dressing after surgery 3. Be monitored for wound complications and signs of infection during the postpartum period

Начало: 01.04.2026 Край: 01.02.2027 Възраст: от 18 г.

United States Montefiore Medical Center NCT07066254

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