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Намерени 4,436 изпитвания Стр. 17 от 222

Набира участници

Assessing the Effects of Corn and Avocado Oils on the Cardiometabolic Risk Factor Profile

Hypercholesterolemia

The goal of this clinical trial is to assess the effects of corn and avocado oils as part of controlled feeding diets on the cardiometabolic risk factor profile in men and women with mild-to-moderately elevated levels of non-high-density lipoprotein cholesterol (non-HDL-C). Participants will be asked to consume the controlled feeding diet for two separate 21 day conditions, and will consume their regular diet for a 21 day washout period between the two conditions. Additionally, participants will be asked to come into the clinic on 7 different occasions, including one screening visit (visit 1, -7 days), one baseline visit (visit 2, day 0), two visits during each 21-d diet condition (visits 3 \& 6, day 19 and visits 4 \& 7, day 21), and a visit at the conclusion of the washout phase/start of the second diet condition (visit 5, day 0).

Начало: 10.04.2026 Край: 01.09.2026 Възраст: 18–74 г.

United States Midwest Center for Metabolic and Cardiovascular Researc NCT07514663

Набира участници

Non-Invasive ICP Monitoring Study

Intracranial Pressure

Measuring the pressure inside the skull, which is called intracranial pressure, is important to treat severe neurological illness. Currently, measuring intracranial pressure requires doctors to place an invasive pressure monitor. Recently, a non-invasive intracranial pressure monitor has been developed. This monitor has a tiny pin that is placed on the head which measures the tiny movements of the skull every time the heart beats. This produces a waveform that looks very similar to an invasive intracranial pressure waveform. However, we don't know enough about how the non-invasive device to make it clinically useful yet.

Начало: 10.04.2026 Край: 01.10.2027 Възраст: от 18 г.

United States University of Texas Southwestern Medical Center NCT07113353

Набира участници

Cerclage Plus Progesterone vs Progesterone Alone in Twin Short Cervix

Preterm

This study aims to compare the effectiveness of cervical cerclage combined with progesterone versus progesterone alone in preventing preterm birth among women with twin pregnancies and a short cervix (cervical length ≤ 30 mm). Participants will be randomly allocated to either the intervention group (cerclage plus progesterone) or the control group (progesterone alone).

Начало: 10.04.2026 Край: 30.05.2029 Възраст: от 18 г.

Vietnam National Hospital of Obstetrics and Gynecology NCT07372495

Набира участници Фаза 3

A Double-blind, Randomized Clinical Trial Evaluating the Efficacy and Safety of Vormatrigine in Adults with Focal Seizures

Focal Epilepsy

Trial status: Authorised Change from baseline in seizure frequency from the Observation Period to the Treatment Period as assessed across the vormatrigine 20 mg, 30 mg and 40 mg dose groups, Seizure Freedom, during the last period, Time to achieve 50% seizure reduction from the Observation Period, Change from baseline in monthly focal seizure frequency from the Observation Period to each month of the Treatment Period for vormatrigine compared with placebo, Impact of vormatrigine compared to placebo on PGI-C and CGI-C, Incidence and severity of TEAEs, including discontinuation of study drug due to TEAEs, Changes in vital sign measurements, Changes in clinical laboratory results, Changes in ECG parameters, Changes in suicidality, as assessed by C-SSRS 50% Responder, defined as at least a 50% reduction in focal seizure frequency from the Observation Period to the Treatment Period

Начало: 10.04.2026 Възраст: от 18 г.

Czech Republic, Germany, Italy +2 Praxis Precision Medicines Inc. 2025-524038-24-00

Набира участници Фаза 2

A Phase 2b, Randomized, Double blind, Placebo controlled, Parallel group, Multicenter, Dose ranging Study Investigating the Efficacy and Safety Profile of KT-621 Administered Orally to Adult Participants with Uncontrolled Moderate to Severe Eosinophilic Asthma

Uncontrolled Moderate to Severe Eosinophilic Asthma

Trial status: Authorised Change from baseline to Week 12 in post-bronchodilator FEV1., Change from baseline to Week 12 in ACQ-5 score, Change from baseline to Week 12 in the AQLQ(S) Global Score, Incidence of TEAEs, Incidence of treatment-emergent SAEs, Plasma PK parameter estimates of KT-621 derived from plasma concentration time data Change from baseline to Week 12 in pre-bronchodilator FEV1.

Начало: 10.04.2026 Възраст: от 18 г.

Austria, Belgium, Germany +5 Kymera Therapeutics Inc. 2025-523180-38-00

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The Spotlight Study: Early Identification of Post-Surgical Infections Using Bedside Ultrasound.

Surgical Site Infection (SSI) Emergency Laparotomies Point of Care Ultrasound (POCUS)

Introduction: The goal of this observational study is to learn whether point-of-care ultrasound (POCUS) can help detect early fluid build-up under the skin after open abdominal surgery (laparotomy) and whether these findings can predict surgical site infection. The study includes adults who recently had emergency or planned open abdominal surgery. Hypothesis: The main questions it aims to answer are: 1. Does ultrasound identify subcutaneous fluid collections early after surgery? 2. Do these fluid collections help predict which participants will develop a surgical site infection? Intervention: Participants will: 1. Have a superficial wound swab taken once at the start of the study (for research only). 2. Receive three ultrasound scans of their surgical wound during days 1-3, 4-6, and 7-9 after surgery. 3. Have their wound checked for redness, swelling, tenderness, or discharge before each scan. 4. Be followed for 7 and 30 days after surgery (and up to 90 days if they have implanted mesh) to see whether an infection develops. Ultrasound is non-invasive and safe. According to the protocol, "no serious adverse effects are expected," though some participants may feel brief discomfort from pressure on a tender wound. This study will help researchers understand whether routine bedside ultrasound can support earlier detection of wound infections and improve postoperative care in the future.

Начало: 10.04.2026 Край: 30.08.2027 Възраст: от 18 г.

Denmark Slagelse Hospital NCT07549880

Набира участници Фаза 2

Evaluation of RBS2418 in Combination With Tremelimumab Plus Durvalumab in Participants With Advanced Unresectable Hepatocellular Carcinoma

Advanced Unresectable Hepatocellular Carcinoma

RBS2418 is a targeted immune modulator that inhibits ectonucleotide pyrophosphatase/phosphodiesterase 1 (ENPP1). It is designed to promote anti-tumor immunity by preserving endogenous 2'-3' cyclic guanosine monophosphate-adenosine monophosphate (cGAMP) from hydrolysis, thereby activating antigen-presenting cells and promoting robust T cell activation. Ideally, RBS2418 acts synergistically with CTLA-4 inhibitors, such as those in the STRIDE regimen (Tremelimumab plus Durvalumab). The hypothesis is that RBS2418 combined with STRIDE will be safe, well-tolerated, highly immunogenic, and enhance anti-tumor responses in adult participants with advanced, unresectable hepatocellular carcinoma (HCC) compared to STRIDE alone.

Начало: 10.04.2026 Край: 01.08.2027 Възраст: от 18 г.

United States Riboscience, LLC. NCT07175441

Набира участници

Cardiovascular Effects of Music Versus Guided Mindfulness

Music Listening Intervention Mindfulness-based Intervention

The purpose of this study is to examine how listening to music compares to guided mindfulness in affecting blood pressure, heart rate, and feelings of anxiety in healthy adults. The investigators aim to determine whether one of these approaches is more effective in reducing these variables. Additionally, the study will explore whether personal traits or preferences, measured using questionnaires, influence how participants respond to music or mindfulness. Based on previous clinical findings, the researchers hypothesize that listening to music will lead to greater reductions in blood pressure and heart rate compared to guided mindfulness.

Начало: 10.04.2026 Край: 01.08.2026 Възраст: 18–75 г.

Canada Sir Mortimer B. Davis - Jewish General Hospital NCT07338500

Набира участници Фаза 3

A Clinical Study of Belzutifan (MK-6482) and Zanzalintinib in People With Renal Cell Carcinoma (RCC) (LITESPARK-034/LS-034/MK-6482-034)

Carcinoma, Renal Cell

Researchers are looking for new ways to treat advanced renal cell carcinoma (RCC). A standard (usual) treatment for certain people with RCC is belzutifan (a study medicine), which is a targeted therapy. Targeted therapy is a treatment that works to control how specific types of cancer cells grow and spread. Researchers want to learn if adding another targeted therapy called zanzalintinib (another study medicine) can treat more people with advanced RCC than belzutifan alone. The goal of this study is to learn if people who receive belzutifan and zanzalintinib live longer overall and without the cancer getting worse compared to people who receive belzutifan and placebo.

Начало: 09.04.2026 Край: 27.11.2030 Възраст: от 18 г.

Australia, Israel, South Korea Merck Sharp & Dohme LLC NCT07489495

Набира участници

Neuromodulation to Enhance Motor Function in HSP

Hereditary Spastic Paraplegia

Hereditary spastic paraplegia (HSP) is a rare neurological condition that causes stiffness, weakness, and difficulty walking due to damage in the nerves that control movement. This study will test whether a noninvasive form of spinal cord stimulation, called transcutaneous spinal cord stimulation (tSCS), can improve walking and reduce muscle stiffness in adults with HSP. In this study, participants will receive tSCS twice a week for 8 weeks. The stimulation is delivered through self-adhesive electrodes placed on the skin over the lower back and does not require surgery. Each session will last about one hour. After the treatment period, participants will be followed for an additional 8 weeks without stimulation to see whether any improvements are maintained. Researchers will measure walking speed, walking endurance, muscle stiffness, and overall disease severity. Additional tests will explore changes in bladder and bowel function and muscle strength.

Начало: 09.04.2026 Край: 01.02.2028 Възраст: от 18 г.

United States Rahul Sachdeva NCT07417943

Набира участници

Preliminary Effectiveness of Enhanced Text Message + Incentives

Smoking Cessation Pregnancy

This study is a preliminary evaluation of a smoking cessation intervention designed for pregnant women that combines text message support and financial incentives. The aims of this study are to determine the preliminary feasibility and acceptability of text message + incentives (intervention) vs. text message only (control).

Начало: 09.04.2026 Край: 01.08.2026 Възраст: от 18 г.

United States University of Kansas Medical Center NCT07420621

Набира участници

Radicle Revive™: A Study Assessing the Impact of Health and Wellness Products on Menopausal-Related Health Issues Associated Health Outcomes and Related Health Outcomes

Cognitive Function

Radicle Revive™: A randomized, double-blind, placebo-controlled study assessing the impact of health and wellness products on menopausal-related health issues associated health outcomes.

Начало: 09.04.2026 Край: 07.04.2027 Възраст: 40–105 г.

United States Radicle Science NCT07548307

Набира участници

Pneumococcal Carriage, Serotypes, and Antibiotic Resistance in Malaysian Children: A Multi-Centre Study

Nasopharyngeal Carriage of Streptococcus Pneumoniae

The goal of this observational study is to determine the prevalence, serotype distribution, and antimicrobial resistance patterns of nasopharyngeal carriage of Streptococcus pneumoniae in Malaysian children aged ≤5 years following the implementation of pneumococcal conjugate vaccines (PCVs). The study focuses on healthy and mildly symptomatic male and female children aged 0-60 months recruited from urban and semi-urban settings in Kuala Lumpur, Selangor, and Negeri Sembilan. The main questions it aims to answer are: 1. What is the overall and age-specific prevalence of nasopharyngeal pneumococcal carriage among children aged ≤5 years in Malaysia? 2. What are the circulating serotypes and antimicrobial resistance (AMR) profiles of pneumococcal isolates, and how are they associated with vaccination status and PCV valency coverage? Researchers will compare carriage prevalence, serotype distribution (vaccine-type vs non-vaccine-type), and antimicrobial resistance patterns across different states, vaccination statuses, and socioeconomic backgrounds to determine differences in transmission dynamics and potential serotype replacement patterns. Participants will: 1. Undergo a nasopharyngeal swab collection for pneumococcal detection. 2. Provide demographic and vaccination history information through a standardised case report form completed with parental/guardian consent. 3. Have their samples analysed using bacterial culture, antimicrobial susceptibility testing, and whole-genome sequencing (WGS) for serotyping and resistance profiling.

Начало: 09.04.2026 Край: 30.06.2027 Възраст: до 5 г.

Malaysia IMU University, Malaysia NCT07545876

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Effect of "RECAST-H" (REverse CAses STudies Based on Heutagogy Approach) on Professional Readiness

Nurses Behaviors Nurses Education, Nursing Students

The goal of this study is to examine the effect of reverse case studies based on the heutagogical approach on the level of readiness for the profession among final-year nursing students. The hypotheses are: H0-1: There is no difference in the level of professional readiness between the control group and the intervention group that underwent reverse case studies based on the heutagogy approach. H0-2: There is no difference in career adaptability between the control group and the intervention group that underwent reverse case studies based on the heutagogy approach. H0-3: There is no difference in professional socialization between the control group and the intervention group that underwent reverse case studies based on the heutagogy approach. Secondary Hypothesis: H0-4: There is no difference in psychological capital levels between the control group and the intervention group that underwent reverse case studies based on the heutagogy approach. Researchers will compare the heutagogy-based reverse case studies program group with the waiting-list control group to evaluate its effects on professional readiness, career adaptability, professional socialization, and psychological capital. Participants will: * complete baseline assessments * be randomly assigned to either the intervention group or the waiting-list control group * receive reverse case studies program based on the heutagogy approach (intervention group) * complete post-intervention assessments after the educational program

Начало: 09.04.2026 Край: 01.06.2026

Turkey (Türkiye) Hacettepe University NCT07539363

Набира участници Фаза 3

A Study to Evaluate Chemotherapy With or Without INCB161734 in Previously Untreated, KRAS G12D-Mutated Metastatic Pancreatic Ductal Adenocarcinoma

Solid Tumors

The purpose of this study is to evaluate the efficacy and safety of standard chemotherapy with or without INCB161734 in participants with metastatic pancreatic ductal adenocarcinoma (PDAC).

Начало: 09.04.2026 Край: 19.03.2029 Възраст: от 18 г. Лечение

Australia, Belgium, Canada +14 Incyte Corporation NCT07522073

Набира участници Фаза 1/2

A Study of Ivonescimab in Combination With Dato-DXd or Osimertinib in People With Non-Small Cell Lung Cancer

Non-Small Cell Lung Cancer

The researchers are doing this study to find out whether ivonescimab in combination with datopotamab deruxtecan- (Dato-DXd) or osimertinib are safe and effective treatments in people with non-small cell lung cancer (NSCLC) that has an EGFR mutation. The researchers will test different doses of the Dato-DXd or osimertinib with an unchanging (fixed) dose of ivonescimab to find the best dose that causes few or mild side effects in participants. Once the dose is found the researchers will test ivonescimab with Dato-DXd or osimertinib in a new group of participants to see if it is effective in treating their NSCLC with an EGFR mutation.

Начало: 09.04.2026 Край: 01.04.2028 Възраст: от 18 г.

United States Memorial Sloan Kettering Cancer Center NCT07535437

Набира участници Фаза 1

A Study to Evaluate the Effect of Food on the Bioavailability of AJ201, and Safety, Tolerability, and Pharmacokinetics of AJ201 in Japanese and White Healthy Male Participants

Healthy Male Adults Food Effect in Healthy Volunteers

This is a Phase 1, randomized, single-dose, open-label, two-way crossover study to evaluate the effect of food on AJ201, and to evaluate the safety, tolerability, and pharmacokinetics of AJ201 in Japanese and White healthy male participants.

Начало: 09.04.2026 Край: 27.04.2026 Възраст: 18–55 г.

United States AnnJi Pharmaceutical Co., Ltd. NCT07549919

Набира участници Фаза 2

C6461020 - An Interventional Open-Label Phase 1b/2 Study to Evaluate the Safety, Pharmacokinetics, and Preliminary Efficacy of PF-08634404 in combination with Different Anticancer Agents in Participants with Advanced Solid Tumors

Advanced Solid Tumors

Trial status: Authorised Phase 1 Safety Run-In: Confirmed ORR per RECIST v1.1 by investigator, DCR per RECIST v1.1 by investigator, DOR per RECIST v1.1 by investigator, PFS per RECIST v1.1 by investigator, OS, Laboratory abnormalities as characterized by type, frequency, severity (as graded by NCI CTCAE version 5.0), and timing., Predose and/or postdose concentrations of PF-08634404, SV, and PF-08046054., Incidence of ADA against PF-08634404, SV, and PF-08046054., Phase 2 Dose Optimization and Dose Expansion: DOR per RECIST v1.1 by investigator, DCR per RECIST v1.1 by investigator, PFS per RECIST v1.1 by investigator, OS, Laboratory abnormalities as characterized by type, frequency, severity (as graded by NCI CTCAE version 5.0), and timing., Predose and/or postdose concentrations of PF-08634404, SV, and PF-08046054., Incidence of ADA against PF-08634404, SV, and PF-08046054. Phase 1 Safety Run-In: AEs as characterized by type, frequency, severity (as graded by NCI CTCAE version 5.0), timing, seriousness, and relationship to study intervention., DLTs., Phase 2 Dose Optimization and Dose Expansion: Confirmed ORR per RECIST v1.1 by investigator, AEs as characterized by type, frequency, severity (as graded by NCI CTCAE version 5.0), timing, seriousness, and relationship to study intervention.

Начало: 09.04.2026 Възраст: от 18 г.

France, Germany, Italy +1 Pfizer Inc. 2025-523526-40-00

Набира участници Фаза 1

AMG 436 as Monotherapy and Combination Therapy in Participants With MSI-H/dMMR Solid Tumors

Metastatic or Locally Advanced Solid Tumors With Microsatellite Instability-high (MSI-H) or Mismatched Repair Deficiency (dMMR)

The primary objectives of this trial are to evaluate the safety profile of AMG 436 and to determine the maximum tolerated dose (MTD) and/or the recommended dose for AMG 436 as monotherapy and in combination with other anti-cancer therapies in participants with MSI-H/dMMR solid tumors.

Начало: 08.04.2026 Край: 28.06.2028 Възраст: 18–99 г. Лечение

Australia, China, Japan +1 Amgen NCT07403721

Набира участници

Building Retention and Initiation Through Delivery of Peer-Guided Evidence-Based Practices

Opioid Use Disorder

This study will provide longitudinal data for 6-months on a target sample of patients with Opioid Use Disorder (OUD) recruited from Prisma Health Mobile Health Clinics in South Carolina. The goal of our study is to increase OUD treatment initiation and retention and maximize prevention of overdose deaths in underserved communities through development, testing, and delivery of a novel intervention targeting areas of optimal allocation of MHC with a Peer Support Specialist (PSS) intervention.

Начало: 08.04.2026 Край: 31.08.2029 Възраст: от 18 г.

United States Prisma Health-Upstate NCT07541417

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