Search trials – HealthDB

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Намерени 4,781 изпитвания Стр. 166 от 240

Not yet recruiting Phase 2/3

Postoperative Radiotherapy With Nimotuzumab ± Benmelstobart in Intermediate-Risk Head and Neck Squamous Cell Carcinoma: A Randomized Controlled Trial

Head and Neck Squamous Cell Carcinoma

A Multicenter, Randomized, Controlled, Open-Label, Phase II/III Clinical Trial to evaluate the efficacy and safety of postoperative radiotherapy and Nimotuzumab with/without Bemcentinib in intermediate-risk pathological patients with head and neck squamous cell carcinoma.The primary endpoint is 3-year disease-free survival (DFS). A total of 193 patients will be enrolled in both the study group and the control group, respectively, with a total planned enrollment of 386 patients.

Начало: 05.05.2026 Край: 31.12.2028 Възраст: от 18 г.

Shanghai Ninth People's Hospital Affiliated to Shanghai NCT07535567

Not yet recruiting Phase 3

A Study of Precemtabart Tocentecan With or Without Bevacizumab Compared to Trifluridine/Tipiracil Plus Bevacizumab in Participants With Previously Treated Metastatic Colorectal Cancer (PROCEADE-CRC-03)

Metastatic Colorectal Cancer

This study aims to address the unmet medical need of participants with metastatic colorectal cancer (mCRC) who have previously been treated with irinotecan, oxaliplatin, a fluoropyrimidine, and bevacizumab, by demonstrating an overall survival prolongation with precemtabart tocentecan (Precem-TcT) as single agent or Precem-TcT in combination with bevacizumab compared to trifluoride/tipiracil (FTD-TPI) plus bevacizumab.

Начало: 05.05.2026 Край: 31.10.2029 Възраст: от 18 г.

Germany, United States EMD Serono Research & Development Institute, Inc. NCT07549412

Not yet recruiting

Feasibility and Health-economic Evaluation of Remote Clinical Monitoring Enabling Same-day Discharge After Bariatric Surgery

Roux-en Y Gastric Bypass

The ultimate goal of this research is to optimize care for patients undergoing laparoscopic bariatric surgery while alleviating pressure on hospital resources and staff. Furthermore, the study aims to generate policy-relevant data that can inform policymakers and healthcare providers in developing funding models and care pathways that balance safety, efficiency, and cost-effectiveness. This could support a broader implementation of ambulatory bariatric surgery without compromising quality of care.

Начало: 05.05.2026 Край: 31.12.2027 Възраст: 18–65 г.

Belgium Jessa Hospital NCT07483775

Not yet recruiting Phase 1

A Drug-Drug Interaction Study of Itraconazole and Opevesostat (MK-5684) in Healthy Adult Male Participants (MK-5684-017)

Healthy

Researchers have designed a study medicine called opevesostat as a new way to treat prostate cancer. The purpose of this study is to learn what happens to opevesostat in a person's body over time (a pharmacokinetic or PK study). Researchers will compare what happens to opevesostat in the body when it is given with and without another medicine called itraconazole.

Начало: 04.05.2026 Край: 14.06.2026 Възраст: 19–55 г.

Merck Sharp & Dohme LLC NCT07548606

Not yet recruiting

Ultrasound-Guided Erector Spinae Plane Block Versus Thoracoscopically-Guided Intercostal Nerve Block in Video-Assisted Thoracoscopic Surgery

Regional Anesthesia Video-assisted Thoracoscopic Surgery (VATS) Erector Spinae Plane Block Intercostal Nerve Block

Effective postoperative pain management is essential after thoracic surgery. Insufficient pain control may impair breathing and coughing, increasing the risk of pulmonary complications such as collapsed lungs (atelectasis) or pneumonia. Although minimally invasive lung surgery (video-assisted thoracoscopic surgery, VATS) is less painful than open surgery, people can still have significant pain after the operation. The goal of this randomized comparative study is to compare two commonly used regional anesthesia techniques for pain control after VATS in adults. Researchers will compare an ultrasound-guided erector spinae plane block (ESPB), performed by anesthesiologists, to a thoracoscopically-guided intercostal nerve block (ICNB), performed by surgeons. Participants will: * Undergo elective VATS lung resection surgery * Receive either ESPB or ICNB, according to random assignment * Have the received amount of analgesics recorded during the first 24 hours * Have their pain levels assessed at predefined time points after surgery The main questions this study aims to answer are: * Does ESPB result in similar analgesic consumption in the first 24 hours after surgery? * Does ESPB provide similar postoperative pain relief compared to ICNB? * Is the time needed to perform ESPB similar to ICNB?

Начало: 04.05.2026 Край: 03.05.2027 Възраст: от 18 г.

Germany Sana Klinikum Offenbach NCT07535697

Not yet recruiting

Effect of Compound (Cardiol Forte) on Lipid And Glycemic Parameters in Low Cardiovascular Risk Individuals

Dyslipidemia

This study will evaluate the effects of a combination dietary supplement, Cardiol Forte, on lipid and glycemic parameters in adults at low cardiovascular risk with suboptimal cholesterol levels. After a 14- to 28-day run-in period with standardized dietary and behavioral instructions, 50 participants will be randomized in a 1:1 ratio to receive either Cardiol Forte or matching placebo for 8 weeks under double-blind conditions. After completion of the double-blind phase, all participants will receive Cardiol Forte for an additional 8 weeks in an open-label extension. The primary objective is to compare the change in non-high-density lipoprotein cholesterol (non-HDL-C) from baseline to Week 8 between Cardiol Forte and placebo. Secondary objectives include evaluation of other lipid parameters, fasting plasma glucose, Omega-3 Index, selected inflammatory and liver-related markers, and endothelial reactivity.

Начало: 04.05.2026 Край: 04.05.2028 Възраст: 18–79 г.

Italy U.G.A. Nutraceuticals NCT07515573

Not yet recruiting

Implementing Transcranial Direct Current Stimulation in a Rehabilitation Setting

Aphasia Stroke

This study looks at whether transcranial Direct Current Stimulation (tDCS) can be effectively implemented in inpatient and outpatient rehabilitation settings during routine speech therapy for people who recently had a stroke and now have aphasia (difficulty speaking or understanding language)

Начало: 04.05.2026 Край: 30.05.2027 Възраст: от 18 г.

Casa Colina Hospital and Centers for Healthcare NCT07535788

Not yet recruiting

Improving Dementia Care in Primary Practice

Alzheimer Disease (AD) Mild Cognitive Impairment (MCI) Dementia

This clinical trial will evaluate a multi-level scalable intervention called Improving Dementia Care (IDC). The investigators hypothesize that IDC will increase dementia detection in patients with impaired cognition more than the control condition, Enhanced Usual Care (EUC), over 6 months.

Начало: 04.05.2026 Край: 03.05.2027 Възраст: от 66 г.

Thomas Jefferson University NCT07526480

Not yet recruiting

Wind Noise Sound Quality Preference and Claims Study

Hearing Loss

Claims evidence is required for a new Wind Noise Canceller (WNC) algorithm. Wind noise is not sound in the classic sense, as it does not correspond to pressure waves moving through the air. However, because the microphone membranes are deflected by the wind noise, the microphones translates them into a sound signal. Since the pressure fluctuations are small in size, this wind noise signal is uncorrelated between the two HI microphones (correlation decreases with increasing microphone distance), creating bothersome sounds at low and very low frequencies. Historically, wind noise cancellers have been applied to make wind noise less bothersome. However, target signal (i.e. speech) sound fidelity can become compromised as a biproduct. Therefore, an updated wind noise canceller has been proposed to improve wind noise attenuation and target signal fidelity compared to the previous iteration. Informal exploratory testing by normal hearing Sonova employees have identified the new wind noise canceller iteration to improve sound quality ratings with some dependencies on (1) wind speed, (2) wind angle and (3) target signal. Therefore, this study will aim to produce sound quality data showing a benefit for the new wind noise canceller compared to the older version for the purpose of claim substantiation.

Начало: 04.05.2026 Край: 31.05.2026 Възраст: 18–99 г.

Canada Jonathan Vaisberg NCT07543770

Not yet recruiting

Burn Pit Exposure in Veterans: A Cancer Screening Pilot Study at the Inova Saville Cancer Screening & Prevention Center

Cancer

The goal of this study is to determine the feasibility and participant satisfaction associated with a more intensive cancer screening regimen in veterans exposed to burn pits. The study results may describe the clinical and psychosocial impact such screening has on this potential population. The study hopes to share the premalignant and malignant findings identified and follow-up healthcare utilization associated with high-intensity cancer screening during the approximately 3-year study period (three annual screening assessments and an additional year of follow-up to determine participants' cancer status). The study will also explore the performance of new tools (nasal brush, multi-cancer detection blood test, and radiomic analysis) in detecting the development of cancer during the study period.

Начало: 02.05.2026 Край: 31.07.2029 Възраст: 35–85 г.

United States Inova Health Care Services NCT07485322

Not yet recruiting

Mandala Activity for Anxiety and Emotional and Psychological Well-Being in Adolescents With Siblings With Special Needs

Anxiety Emotional Well-being Psychological Well-being

The purpose of this randomized controlled trial is to evaluate whether a structured mandala activity program can reduce anxiety and improve emotional and psychological well-being in adolescents who have a sibling with special needs. Adolescents in this group may experience emotional difficulties because of the demands and challenges associated with having a sibling who requires special care and support. However, supportive and accessible interventions for these adolescents are limited. In this study, eligible participants will be randomly assigned to either an intervention group or a control group. The intervention group will participate in a structured mandala activity program, while the control group will not receive this program during the study period. Anxiety and emotional and psychological well-being will be assessed before and after the intervention using standardized measurement tools. The main question of this study is whether participation in the mandala activity program leads to better mental well-being outcomes compared with the control group. The findings may help determine whether mandala-based activities can be used as a simple, supportive, and non-pharmacological approach for adolescents who have a sibling with special needs.

Начало: 02.05.2026 Край: 30.06.2026 Възраст: 10–19 г.

Turkey (Türkiye) Akdeniz University NCT07551180

Not yet recruiting Phase 1

Phase I Clinical Study on the Safety and Efficacy of CY-219 CAR-T Cell Injection in the Treatment of Relapsed/Refractory B-Cell Lymphoma

Relapsed/Refractory B-cell Lymphoma Diffuse Large B-cell Lymphoma Inert B-cell Lymphoma Transformed Into Large B-cell Lymphoma (Excluding Richter Transformation, THRLBCL, and BL)

This study is an open-label, single-arm, prospective clinical trial involving patients with relapsed/refractory B-cell lymphoma, aimed at evaluating the safety and efficacy of CAR-T cell infusion.

Начало: 01.05.2026 Край: 01.12.2029 Възраст: 18–75 г.

Institute of Hematology & Blood Diseases Hospital, Chin NCT07539688

Not yet recruiting

Management of Steatorrhea in Children and Young Adults With Alagille Syndrome After Liver Transplantation

Exocrine Pancreatic Insuficiency

The goal of this clinical trial is to determine the prevalence of exocrine pancreatic insufficiency (EPI) in a population of pediatric and adult participants with Alagille Syndrome (ALGS) post liver transplant. During the study, participants will: * Consume a high fat diet * Keep a diary of their abdominal signs and symptoms, and stool frequency and consistency * Collect stool for laboratory testing

Начало: 01.05.2026 Край: 01.05.2028 Възраст: 7–50 г.

Digestive Care, Inc. NCT07335523

Not yet recruiting

Ambispective Validation of the Odesa Criteria 2026 (OC26): A Flexible Point-Based System for Diagnosis of Autoimmune Pancreatitis.

Autoimmune Pancreatitis IgG4-Related Diseases Pancreatic Cancer Chronic Pancreatitis

Approval Number protocol 020237 Board Name Ethics Committee of the Military Medical Clinical Center of the Southern Region. Board Affiliation Military Medical Clinical Center of the Southern Region, Ukraine. Board Contact Information Phone: +380 (50) 316-10-54)

Начало: 01.05.2026 Край: 31.12.2026 Възраст: от 18 г.

Military Medical Clinical Center of the Southern Region NCT07536841

Not yet recruiting

Implementation of a Beauty Salon-Based Strategy for Blood Pressure Management Among Women

Hypertension

CROWN is a two-arm, cluster-randomized pilot trial testing the feasibility and preliminary efficacy of a salon-based cardiovascular intervention - training stylists as Heart Health Stylists to conduct in-salon blood pressure screenings, home monitoring with telehealth support, community health-worker coaching, and pharmacist-led medication management - among Black and Hispanic women with hypertension.

Начало: 01.05.2026 Край: 31.05.2028 Възраст: 18–79 г.

United States Johns Hopkins University NCT07042386

Not yet recruiting

Health Enhanced Artery Risk Tracking With Widespread Implementation and Screening Effort in ASCVD (HEARTWISE-ASCVD)

Atherosclerotic Cardiovascular Disease (ASCVD) Coronary Artery Calcification

This multi-site study will test whether an opportunistic AI-based CAC screening and notification intervention can improve cholesterol treatment and lower cholesterol levels in adults. The study uses artificial intelligence to detect calcium buildup in heart arteries (coronary artery calcium or CAC) on chest CT scans that patients have already had for other reasons. The study will focus on adults who either have known atherosclerotic cardiovascular disease (ASCVD) or have significant calcium buildup (a CAC score of 100 or higher), and whose cholesterol is not well controlled. It will also evaluate how well this approach can be implemented at scale across multiple health systems. The main questions it aims to answer are: Does notifying patients and their clinicians about incidental CAC increase lipid-lowering therapy(LLT) initiation or intensification? Does the intervention improve Low-Density Lipoprotein(LDL)-cholesterol control and related lipid testing? How does the intervention affect downstream care (e.g., clinic visits, cardiology referrals, and cardiac testing)? Researchers will use an FDA-cleared AI algorithm to quantify CAC on previously performed non-gated chest CT scans and identify eligible participants through the electronic health record. Participants will be randomized to receive CAC notification either right away or after a 6-month delay.

Начало: 01.05.2026 Край: 01.03.2028 Възраст: 18–74 г.

United States Stanford University NCT07355894

Not yet recruiting

Effect of DFM on Quadriceps Spasticity in Stroke Patients

Stroke (Subacute)

The goal of this clinical trial is to learn if deep friction massage works to reduce quadriceps muscle spasticity in adults with sub-acute Stroke. It will also learn about the effectiveness of this technique in improving lower limb motor function and mobility. The main questions it aims to answer are: * Does deep friction massage reduce quadriceps spasticity in stroke patients as measured by the Modified Ashworth Scale? * Does deep friction massage improve lower limb motor recovery as measured by the Fugl-Meyer Assessment? * Does deep friction massage improve functional mobility as measured by the Timed Up and Go Test? Researchers will compare deep friction massage combined with conventional physiotherapy to conventional physiotherapy alone to see if deep friction massage improves spasticity and functional outcomes in patients with stroke.

Начало: 01.05.2026 Край: 30.12.2027 Възраст: от 40 г.

Majmaah University NCT07537322

Not yet recruiting

A Multiphase Operational and Environmental Assessment of Lunar Surface Habitation, Lunar Gateway Transit Systems, and Acceleration Pathways for Sustained Human Habitation of the Martian Surface

Extraterrestrial Habitation Systems Lunar Surface Habitation Lunar Water-Ice Resource Assessment In-Situ Resource Utilization (ISRU) +6

This study evaluates the operational, environmental, and habitation-system requirements for sustained human presence on the lunar surface, the performance of the Lunar Gateway as a transit and staging architecture, and the pathways required to accelerate readiness for Martian surface habitation. The protocol examines habitat resilience, radiation exposure modeling, life-support continuity, EVA logistics, behavioral health in isolated environments, and systems-engineering workflows across lunar, transit, and Mars-analog environments. Special emphasis is placed on the identification, extraction, processing, and utilization of lunar water-ice deposits as a critical resource for life-support, radiation shielding, and in-situ propellant production. Findings will inform future mission design, habitation module development, and interplanetary operational frameworks.

Начало: 01.05.2026 Край: 30.04.2029 Възраст: 18–65 г.

United States Truway Health, Inc. NCT07546461

Not yet recruiting

Fuzzle System for Appetite Control and Weight Management

Obesity & Overweight

This study is evaluating whether the Fuzzle intraoral device can help adults with obesity lose weight when used alongside standard lifestyle counseling. Participants in this study will receive guidance on diet and behavior to support weight loss. Some participants will also receive the Fuzzle device, a custom-made removable oral appliance worn during the day. The study will compare weight loss outcomes between participants who use the Fuzzle device and those who follow lifestyle counseling alone over a 16-week period. Researchers will also explore whether use of the device increases the number of participants who achieve meaningful weight loss and may evaluate changes in selected metabolic markers in a subset of participants.

Начало: 01.05.2026 Край: 01.09.2026 Възраст: 18–65 г.

United States Fuzzle Operating Co. NCT07527559

Not yet recruiting Phase 4

Efficacy and Cost-Effectiveness of Topical Vancomycin Powder in Preventing Pediatric Ventriculoperitoneal Shunt Infections Across Different Etiologies

Hydrocephalus Ventriculoperitoneal Shunt Infection Surgical Site Infection (SSI) Cerebrospinal Fluid Shunt Infection +6

Objectives * Primary: * To measure the reduction in VP shunt infection rates using topical vancomycin powder. * Secondary: * To compare efficacy across different Etiological Strata (Congenital, Post-hemorrhagic, post-inflammatory). * To analyze the microbiological profile of failed cases. * To compare the "Time-to-Infection" and shunt survival rates between the study and control groups using Kaplan-Meier analysis. * To evaluate the cost-effectiveness of TVP compared to the standard management and historical AIC data

Начало: 01.05.2026 Край: 01.12.2027 Възраст: 1–18 г.

Egypt Assiut University NCT07547826

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