Search trials – HealthDB

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Намерени 4,781 изпитвания Стр. 164 от 240

Not yet recruiting

Harvest Share Clinical Outcomes

Diet Habit

This pilot study aims to assess the feasibility and acceptability of collecting clinical outcomes amongst Building Access to Food through System and Solidarity (BASIS) participants (s22-00299). BASIS aims to implement a whole-of-community intervention in Brooklyn for improving diet and the social and build environments for English-, Chinese-, and Spanish-speaking communities. BASIS is a single-site program that is being evaluated over a period of 4 years. Each year, culturally appropriate produce will be provided weekly in the form of community-supported agriculture for 20 weeks to community members in Sunset Park, Brooklyn and surrounding neighborhoods. Specifically, we aim to collect cholesterol, blood pressure (BP), and dietary inflammation measures to evaluate impacts of BASIS on clinical outcomes.

Начало: 18.05.2026 Край: 28.02.2027 Възраст: от 18 г.

NYU Langone Health NCT07548619

Not yet recruiting

Kentucky Women's Justice Community Overdose Innovation Network - Phase II

Overdose Risk Opioid Use Disorder Stimulant Use Disorders

This project continues our work with women in the Kentucky Women's Justice Community Overdose Innovation Network Phase II (WJCOIN-II) with the overall aim of reducing overdose risk during the transition from jail to rural communities. WJCOIN-II has potential for significant impact regarding the effectiveness, implementation, and sustainability of innovative overdose prevention strategies during the high-risk time of community re-entry among vulnerable, CLS-involved women in rural communities. This research will impact the field by increasing the capacity of the criminal legal system to respond to the overdose crisis through increased access to prevention strategies to reduce overdose risk.

Начало: 18.05.2026 Край: 30.10.2030 Възраст: от 18 г.

United States Michele Staton NCT07179614

Not yet recruiting

Postoperative Insulin Intervention After Pancreatectomy in nDM Patients

Postoperative Hyperglycemia Pancreatectomy

The goal of this randomized non-inferiority clinical trial is to evaluate whether routine postoperative insulin infusion can be safely omitted in preoperative non-diabetic adult patients undergoing pancreatectomy for periampullary or pancreatic tumors. The primary purpose is to determine whether withholding insulin infusion provides comparable glycemic control while reducing treatment-related burden and adverse events. The main questions it aims to answer are: * Does omission of postoperative insulin infusion result in non-inferior mean blood glucose levels through postoperative day (POD) 3 compared to standard insulin infusion? * Does omission of insulin infusion reduce the incidence of hypoglycemia without increasing postoperative complications, including surgical site infection within 3 months? Researchers will compare a no-insulin infusion group (intervention arm) with a standard insulin infusion group (control arm) to determine whether avoiding routine insulin infusion maintains comparable glycemic control while improving safety and patient comfort. Participants will: * Undergo pancreatectomy and be randomly assigned (1:1) to either receive standard insulin infusion or no routine insulin infusion postoperatively * Have blood glucose monitored using intermittent testing and continuous glucose monitoring (flash glucose monitoring system) * Receive protocol-based glycemic management, including rescue insulin if hyperglycemia occurs or discontinuation if hypoglycemia develops * Be followed for up to 3 months postoperatively to assess glycemic outcomes, hypoglycemic events, surgical site infection, and other postoperative complications * Complete a questionnaire assessing discomfort related to glucose monitoring and insulin administration This study aims to establish evidence-based postoperative glucose management strategies for non-diabetic patients undergoing pancreatectomy.

Начало: 18.05.2026 Край: 31.03.2030 Възраст: 18–80 г.

South Korea Dae Wook Hwang NCT07540975

Not yet recruiting

Nudging for Anticoagulation Adherence in Atrial Fibrillation

Atrial Fibrillation (AF)

The goal of this clinical trial is to learn if a nudging intervention (using text message reminders, a medication calendar, and action planning) can help people with atrial fibrillation take their blood-thinning medication (anticoagulants) as prescribed. The main questions it aims to answer are: Does the nudging intervention improve medication adherence compared to usual care? How does the intervention affect patients' beliefs about their medication and the automaticity of pill-taking? Is the intervention cost-effective? Researchers will compare participants who receive the nudging intervention with those who receive usual care. Participants will: Watch a short educational video about atrial fibrillation and stroke prevention Make a personal plan to take their medication at the same time each day (for example, after breakfast) Receive text message reminders 1 to 3 times per week, with fewer messages over time Get a medication calendar to track daily doses Answer a few questionnaires at the start, at 8 weeks, and at 12 weeks

Начало: 18.05.2026 Край: 20.02.2027 Възраст: от 18 г.

China Sun Yat-sen University NCT07543393

Not yet recruiting

Acute Beetroot Juice Supplementation in Pre-eclampsia Pregnancies

Pre-Eclampsia Pregnacy

Pre-eclampsia is a serious condition that typically affects pregnant women after the 20th week of pregnancy, characterized by high blood pressure and damage to organs such as the kidneys and liver. Currently, treatment options are limited, which has prompted researchers to explore alternative approaches. One such promising alternative is dietary nitrate found in vegetables like beetroot, as nitrate can be converted into nitric oxide in the body, which helps lower blood pressure. This study aims to determine the acute effects of nitrate-rich beetroot juice on blood pressure, several blood and salivary markers in pregnant women with pre-eclampsia and healthy pregnant. Furthermore, the study will assess fetal blood flow using Doppler ultrasound. We want to understand the kinetics of nitrate and nitric oxide metabolites and assess the temporal dependency of the hypotensive response. Through this investigation, we seek evidence of nitrate-enriched beetroot juice as an adjunct therapy in managing pre-eclampsia.

Начало: 18.05.2026 Край: 01.07.2028 Възраст: 18–40 г.

Brazil University of Sao Paulo NCT06387784

Not yet recruiting

To Evaluate Safety and Effectiveness of Meril's Myval Transcatheter Heart Valve (THV) Series Compared toGuideline-Directed Medical Therapy (GDMT) in Participants With Moderate Aortic Stenosis.

Moderate Aortic Valve Stenosis

The primary objective of this trial is to evaluate the safety and effectiveness of Meril's Myval THV series in comparison to Guideline-Directed Medical Therapy in participants with moderate aortic stenosis. The trial includes a total of 778 participants (389:389) from approximately 50 investigator sites globally.

Начало: 17.05.2026 Край: 12.05.2038 Възраст: от 65 г. Treatment

Australia, Belarus, Brazil +17 Meril Life Sciences Pvt. Ltd. NCT07532317

Not yet recruiting

A Real-World Study of Inavolisib in Patients With HR-Positive/HER2-Negative, PIK3CA-Mutated Advanced Breast Cancer

Breast Cancer

A Multicenter, Observational Study on the Real-World Effectiveness and Safety of inavolisib Combined with Endocrine Therapy With or Without a CDK4/6 Inhibitor in Patients with HR-Positive/HER2-Negative, PIK3CA-Mutated Advanced Breast Cancer.

Начало: 16.05.2026 Край: 30.07.2027 Възраст: от 18 г.

xuliang NCT07543250

Not yet recruiting

Evaluating the Feasibility and Reliability of Using Handheld Nebulizers to Conduct Cough Sensitivity Testing With Citric Acid

Cough Reflex Sensitivity

Objective cough reflex sensitivity testing is typically restricted to specialized research laboratories due to reliance on expensive dosimeter-controlled aerosol delivery systems. This study evaluates the feasibility and reliability of a low-cost alternative method using a handheld nebulizer for citric acid cough challenge testing. Healthy adult participants will complete cough reflex sensitivity testing using both a standard dosimeter-controlled nebulizer system (Cosmed QuarkSpiro) and a handheld nebulizer (DeVilbiss 45). The study will compare cough threshold outcomes between methods to determine whether handheld nebulizer-based testing produces comparable and reproducible measurements.

Начало: 16.05.2026 Край: 28.02.2027 Възраст: 18–89 г.

University of Montana NCT07531901

Not yet recruiting

Decision Aid Efficacy in Low Risk Thyroid Cancer

Differentiated Thyroid Cancer (DTC) Papillary Thyroid Microcarcinoma Papillary Thyroid Carcinoma

Low-risk thyroid cancer grows very slowly. More than 99% of patients with this cancer survive for at least 5 years. There are 3 main treatment options: remove the whole thyroid, remove just the part of the thyroid with the cancer in it, or leave the cancer in the thyroid and monitor it. Survival is similar across the 3 main treatment options. It can be difficult for patients to choose a treatment option, especially when feeling anxious about the cancer diagnosis. In this study, enrolled patients will receive a decision aid after finding out they have cancer but before meeting a surgeon. This decision aid is a pamphlet. It gives information about the treatment options and a list of questions for patients to ask their surgeons at their clinic visit. The investigators will test whether this aid changes patient decision anxiety and decision readiness.

Начало: 15.05.2026 Край: 15.06.2029 Възраст: от 18 г.

United States University of Maryland, Baltimore NCT07536412

Not yet recruiting

Effect of AI-Assisted Anatomical Visualization on Anxiety and Kinesiophobia in Knee Arthroplasty Patients

Knee Osteoarthritis Total Knee Arthroplasty

Total knee arthroplasty (TDA) is an effective surgical method applied to reduce pain, improve joint function, and enhance quality of life in patients with advanced osteoarthritis or joint degeneration. However, it is known that surgical success is not limited to the operation itself; pre- and post-operative processes are at least as important as the surgical technique. In particular, active patient participation, early mobilization, and adherence to exercises during the rehabilitation period directly affect treatment outcomes. Patient education plays a critical role in this process. Accurate and sufficient information reduces patients' anxieties about the surgical process and increases their confidence in the recovery process. It also prevents the development of kinesiophobia (fear of movement), supporting patients in participating in physical activity more quickly and safely. Patient education can be provided through various methods. Traditional approaches include face-to-face clinical training, verbal information provided by nurses or physiotherapists, written brochures, and visual materials. While this standard clinical training is effective in conveying basic information, it may have limitations in patients' ability to recall information and adapt it to daily life. In recent years, technology-based training methods have gained increasing importance. In particular, AI-assisted video-based anatomical visualization training can present the structure of the surgery, the placement of the prosthesis, and the movement mechanism to patients in a more understandable and visual way. Such interactive and visually rich training offers advantages in terms of increasing patients' knowledge levels, reducing anxiety, and strengthening their participation in treatment. In conclusion, success after total knee arthroplasty depends not only on the surgical intervention but also on effective patient education. Comparing standard clinical training with AI-assisted visual training methods constitutes an important area of research for improving patient outcomes.

Начало: 15.05.2026 Край: 15.11.2026 Възраст: от 55 г.

Ataturk University NCT07545447

Not yet recruiting

Game-Based Intervention to Reduce Alcohol Use Among Youth

Alcohol Problem

This is a randomized controlled trial to learn if the Singularities, a game-based intervention, works to reduce alcohol-related harms among youth. It will also learn if Singularities reduces alcohol use behaviors and improves alcohol protective behavioral strategies, adaptive coping skills, and healthy social media use. The main questions it aims to answer are: * Does Singularities reduce the frequency of experiencing alcohol-related harms and alcohol use behaviors? * Does Singularities improve alcohol protective behavioral strategies, adaptive coping skills, and healthy social media use? Researchers will compare Singularities to an attention control program, Food4Thought, a game-based intervention about nutrition, physical activity, and teen well-being, to see if Singularities works to reduce alcohol-related harms. Participants will: * Partake in either Singularities or Food4Thought, both of which will be completed over the course of one month * Take 4 online surveys over the course of one year * Complete an optional online interview after the surveys

Начало: 15.05.2026 Край: 30.06.2028 Възраст: 14–18 г.

United States University of Pittsburgh NCT07463118

Not yet recruiting

Digital Health for Patellofemoral Pain

PFPS

This randomized controlled superiority trial will compare a 6-week digital health rehabilitation program with a 6-week self-guided exercise program in adults with patellofemoral pain. Assessments will be performed at baseline, 6 weeks, and 18 weeks. The primary outcome will be change in AKPS from baseline to 6 weeks. Secondary outcomes will include pain intensity, self-reported function, psychological outcomes, quality of life, muscle strength, adherence, and adverse events.

Начало: 15.05.2026 Край: 15.05.2027 Възраст: 18–45 г.

Chengdu Sport University NCT07544940

Not yet recruiting

Rocking Chairs as Post-operative Treatment for Older Adults After Hip Surgery

Postoperative Care

Feasibility and acceptability randomized controlled trial exploring the use of a rocking chair after a total hip arthroplasty in adults who are aged 65 or older. Primary aims include its feasibility and acceptability; exploratory aims include the impact of rocking on pain, gastrointestinal effects, anxiety, ambulation, and additional healthcare visits.

Начало: 15.05.2026 Край: 31.10.2026 Възраст: от 65 г.

University of Missouri, Kansas City NCT07544550

Not yet recruiting Phase 1

aKLmRNA-mediated Protein Replacement Therapy

Aging

This is a Phase 1b randomized, double-blind, placebo-controlled study to assess the safety and tolerability of a proprietary aKLmRNA formulated in lipid nanoparticles. Approximately 21 subjects will be enrolled. Each subject will receive a total of two injections during the study. The cohort will consist of approximately 21 subjects, with each receiving 0.5 mg aKLmRNA (AKL003) or placebo. Subjects will be randomized in a 2:1 ratio (active treatment:placebo). The placebo will be saline, matching the active treatment in both appearance and volume.

Начало: 15.05.2026 Край: 30.11.2026 Възраст: 50–75 г.

Honduras Klothea Bio Inc NCT07544420

Not yet recruiting

Plasma Host-Microbe Proteomics to Predict Complications in High-risk Febrile Neutropenia

Febrile Neutropenia

Febrile neutropenia (FN) is a common oncologic emergency in patients with hematologic malignancies, associated with high morbidity and mortality. Early identification of patients at higher risk of complications such as sepsis or septic shock is critical to optimize antimicrobial management. This study aims to characterize the human and microbial plasma proteome using high-resolution mass spectrometry to identify biomarker combinations ("combitypes") capable of predicting complications in oncohematologic patients with FN. A cohort of 350 adult patients with high-risk FN and initially uncomplicated clinical presentation will be enrolled across three tertiary hospitals. Plasma samples will be collected at fever onset (before antibiotic initiation) and after 48 hours. Proteomic data will be integrated with clinical information using multivariate and machine learning models to develop a predictive model for complications.

Начало: 15.05.2026 Край: 01.01.2029 Възраст: от 18 г.

Spain Instituto de Investigación Biomédica de Salamanca NCT07277387

Not yet recruiting Phase 1

Effects of Various Cannabis Strains on Perceptual, Subjective and Objective Use Outcomes

Cannabis Intoxication

This study will evaluate the subjective and behavioral effects of cannabis products labeled as indica, sativa, or generic.

Начало: 15.05.2026 Край: 01.09.2029 Възраст: 21–55 г.

Johns Hopkins University NCT07214155

Not yet recruiting

TMH And Ultrasound For Difficult Airway Prediction

Difficult Airway Airway Management

This prospective observational study aims to evaluate the predictive value of thyromental height (TMH) and ultrasonographic airway measurements in predicting difficult airway in adult patients undergoing elective surgery under general anesthesia. Preoperative airway assessment will include standard clinical evaluation, TMH measurement, and ultrasonographic measurements of anterior neck soft tissue. Perioperative airway management data, including intubation difficulty, number of attempts, and Cormack-Lehane classification, will be recorded. The relationship between preoperative measurements and difficult airway will be analyzed to determine their predictive accuracy and clinical usefulness.

Начало: 15.05.2026 Край: 15.05.2027 Възраст: от 18 г.

Turkey (Türkiye) Bursa City Hospital NCT07547943

Not yet recruiting

Leveraging Optimal Tolerance in Undernourished Infants to Support Growth

Faltering Growth Failure to Thrive

The goal of this study is to learn if InfaCore (IC) an energy and nutrient dense formulation (ENDF) can improve growth and tolerance in infants with or at risk of growth faltering when fed IC.

Начало: 15.05.2026 Край: 15.05.2027 Възраст: 1–12 г.

Thailand Dutch Medical Food NCT07549360

Not yet recruiting

Implant Placement Depth and Peri-Implant Tissue Outcomes

Dental Implant Placement Soft Tissue Management in Subcrestal Dental Implants Marginal Bone Loss

The primary aim of this randomized clinical trial is to evaluate the influence of subcrestal implant placement depth (-2 mm vs -4 mm) on peri-implant marginal bone level changes, including marginal bone loss and bone remodeling. Secondary outcomes include implant success, peri-implant probing depth (PPD), and bleeding on probing (BoP). Partially edentulous patients requiring fixed implant-supported prosthetic rehabilitation with two implants in posterior maxillary or mandibular regions will be included. Implants will be placed subcrestally at either -2 mm or -4 mm from the bone crest, following a submerged healing protocol. Allocation to insertion depth will be randomized. Marginal bone level changes will be assessed using standardized periapical radiographs at second-stage surgery, prosthesis placement, and at 1, 3, 6, and 12 months after functional loading. PPD and BoP will be recorded at the same time points.

Начало: 15.05.2026 Край: 20.07.2027 Възраст: от 18 г.

Spain University of Valencia NCT07535528

Not yet recruiting Phase 1

Yoga for Black and Brown Women Who Have Experienced Abuse From an Intimate Partner

Intimate Partner Violence (IPV) Psychological Well Being Psychological Trauma, Historical

The goal of this clinical trial is to determine if a culturally tailored and trauma-informed yoga (CT-TIY) program improves the overall well-being of Black and Brown women who have experienced IPV. The main questions it aims to answer are: * What is the feasibility, acceptability, and safety of delivering the CT-TIY program? * Do participants randomized to the CT-TIY program experience increases in our primary outcome of psychological well-being relative to women randomized to an enhanced care-as-usual control condition? * Do participants randomized to the CT-TIY program experience improvements in our secondary outcomes of empowerment, resilience, health-related quality of life, collective self-esteem, and culturally specific coping relative to participants randomized to an enhanced care-as-usual control condition? Researchers will compare CT-TIY to enhanced care-as-usual to see if CT-TIY to determine the feasibility, acceptability, safety, as well as initial efficacy of the yoga program. Participants randomized to the CT-TIY program will: * Have 15 weeks to complete a target of 10 CT-TIY yoga classes * Provide feedback on the CT-TIY program after each class they attend * Complete assessments at Baseline, after completing the CT-TIY program (week 16), as well as 3-months (week 27) after completing the CT-TIY program * Complete an exit interview where they provide feedback on their experiences in the yoga program Participants randomized to the enhanced care-as-usual control condition will: * Receive a referral to a domestic violence provider and the Futures without Violence General Health Safety Card, designed to help women recognize how their relationship impacts their health and the lives of their children, and provides information on safety planning and hotlines for support. * Complete assessments at Baseline, week 16, and week 27 of the study.

Начало: 15.05.2026 Край: 31.12.2027 Възраст: от 18 г.

United States The University of Akron NCT07546266

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