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Phase I/II Trial of ONC-PluReceptor NK Cells With Epcoritamab and Tafasitamab for Patients With Recurrent or Refractory B-cell Non-Hodgkin Lymphoma

Recurrent B-Cell Non-Hodgkin Lymphoma Refractory B-cell Non-Hodgkin Lymphoma

The goal of this clinical research study is to learn if ONC-PluReceptor NK cell therapy (combined with the monoclonal antibody therapies epcoritamab and tafasitamab) can help to control relapsed or refractory B-cell Non-Hodgkin Lymphoma. The safety of this treatment will also be studied.

Начало: 01.06.2026 Край: 30.09.2033 Възраст: от 18 г.

United States M.D. Anderson Cancer Center NCT07283679

Предстои набиране Фаза 3

A Study to Learn More About How Safe Finerenone is, When it is Taken for a Longer Time With Standard Treatment, in Children and Young Adults With Heart Failure and Left Ventricular Systolic Dysfunction

Left Ventricular Systolic Dysfunction Heart Failure (Pediatric)

Researchers are looking for a better way to treat children and young adults who have heart failure with left ventricular systolic dysfunction (LVSD). Heart failure with left ventricular systolic dysfunction (LVSD) is a condition where the left side of the heart is weak and struggles to pump blood effectively, leading to symptoms like shortness of breath, fatigue, and poor growth. The study treatment, finerenone (also called BAY94-8862), is under development to treat newborns, children, and young adults with heart failure and LVSD. It works by blocking a protein that contributes to inflammation, scarring, and thickening in the heart and blood vessels, which may help the heart pump more blood effectively. The main purpose of this study is to learn about how safe finerenone is and how well it works in the long-term treatment of heart failure and LVSD. To understand how safe the treatment is, the study team will gather information on the number of patients who experience medical problems after taking finerenone, also known as "treatment emergent adverse events" (TEAEs). Additionally, they will collect blood samples to measure levels of an electrolyte called potassium and monitor blood pressure. They will also assess kidneys function using the estimated glomerular filtration rate (eGFR). In this study, which is an extension of the earlier done FIORE study, finerenone will also be studied in newly enrolled newborns under 6 months with heart failure and LVSD and children and young adults from the FIORE study. The participants will be aged from newborns up to 18 years. All the participants will continue to receive their standard treatment as routine care for heart failure, along with finerenone during the study. The participants will be in the study for around 10 to 11 months, depending on whether they rolled-over from the FIORE study or are newly enrolled newborns and infants \

Начало: 01.06.2026 Край: 30.12.2030 Възраст: до 18 г.

Argentina, Austria, Belgium +20 Bayer NCT07192952

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Enhancing Diabetes Care by Treating Insomnia

Diabetes Type 2 Insomnia

Insomnia is highly prevalent in individuals with type 2 diabetes (T2D) and is associated with poor glycemic control. Louisiana has one of the highest diabetes prevalence rates in the U.S., with significant disparities by race, income, and rural residence. Despite growing recognition of sleep's role in diabetes management, sleep disturbances remain largely unaddressed in diabetes care. Cognitive behavioral therapy for insomnia (CBT-I) is the first-line treatment for chronic insomnia, yet it is underutilized in primary care clinics such as federally qualified health centers (FQHCs) that serve high-risk populations. The long-term goal of this research is to improve cardiometabolic health and reduce diabetes disparities by integrating sleep interventions into diabetes care. This pilot study aims to: (1) evaluate the impact of CBT-I on sleep and diabetes-related outcomes, and (2) assess the acceptability, feasibility, and fidelity of implementing a 6-week CBT-I program in an FQHC setting. The investigators will conduct a randomized controlled trial (RCT) with 30 FQHC patients (aged 40+) with uncontrolled T2D (HbA1c \>7%) and comorbid insomnia (Insomnia Severity Index (ISI) score ≥15). Participants will be randomly assigned to either the CBT-I intervention or usual care. Sleep (ISI scores, actigraphy) and cardiometabolic (HbA1c, fasting glucose, insulin) outcomes will be assessed at baseline and three months post-randomization. Implementation success will be evaluated using fidelity, feasibility, and acceptability measures. Findings will provide preliminary evidence for integrating CBT-I into primary care, informing larger trials to improve diabetes outcomes and reduce disparities in Louisiana.

Начало: 01.06.2026 Край: 28.02.2027 Възраст: от 40 г.

United States Tulane University NCT07062406

Предстои набиране Фаза 2

Gemcitabine and Docetaxel With or Without Bevacizumab (Onbevzi) for Soft Tissue Sarcoma

Neoplasms of Connective and Soft Tissue With an Unspecified Anatomical Site

Arm1- bevacizumab (Onbevzi) at a dose of 15 mg/kg administered as a 30-minute intravenous infusion on Day 1 of each 21-day cycle, followed by intravenous infusion of gemcitabine and docetaxel in sequence. On Day 8 of each cycle, gemcitabine and docetaxel will be administered as a 60-minute intravenous infusion. Arm2- On Day 1 of each 21-day cycle, gemcitabine will be administered first, followed by docetaxel as an intravenous infusion. On Day 8, gemcitabine and docetaxel will be administered as intravenous infusions.

Начало: 01.06.2026 Край: 30.11.2028 Възраст: 18–79 г.

Yonsei University NCT07547592

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Online Study on the Impact of a Self-Help Tool for Social Anxiety

Social Anxiety

The goal of this clinical trial is to understand which individuals benefit most from an internet-based cognitive behavioral intervention for social anxiety. Adults aged 18-65 will complete a self-guided online program designed to reduce anxiety symptoms. The investigators will use a combination of self-reported clinical information and data from computerized decision-making and cognitive tasks to predict changes in symptom scores from the intervention.

Начало: 01.06.2026 Край: 01.04.2027 Възраст: 18–65 г.

United States Trustees of Princeton University NCT07408102

Предстои набиране Фаза 2

SCI-110 in the Treatment of Tourette Syndrome

Tourette Syndrome

To evaluate the efficacy, safety and tolerability of the cannabinoid-based medication SCI-110 compared to placebo in subjects with Tourette syndrome.

Начало: 01.06.2026 Край: 01.02.2028 Възраст: 18–65 г.

Germany, Israel, United States Neurothera Labs Inc. NCT05126888

Предстои набиране Фаза 1

TACrolimus Targeted Immunosuppression Cessation in ALlogeneic HCT

GVHD Hematopoietic Cell Transplantation (HCT) Acute Myeloid Leukemia (AML) Myelodysplastic Syndromes +3

The purpose of this study is to test the feasibility and safety of early cessation of tacrolimus following allogeneic hematopoietic cell transplantation (HCT). Post-HCT tacrolimus is given to prevent graft-vs-host-disease (GVHD), but with the use of post-transplant cyclophosphamide (PTCy), the modern approach to GVHD prevention, GVHD rates have reduced markedly.

Начало: 01.06.2026 Край: 01.02.2028 Възраст: 18–80 г.

United States Stanford University NCT07302776

Предстои набиране Фаза 4

Teen Vulnerability to Irritability: Brain and Estrogen Changes

Depression - Major Depressive Disorder Irritability

Purpose: Risk of severe psychopathology increases dramatically during adolescence, especially for females. Changes in ovarian steroids across the menstrual cycle produce windows of vulnerability to mood disturbances, particularly during the abrupt withdrawal of estradiol (E2) and progesterone (P4) prior to menses onset. Irrefutable evidence links stress with affective symptoms, potentially mediated by E2-related modifications of frontolimbic connectivity and prefrontal gamma-aminobutyric acid (GABA) inhibitory signaling. The primary objective of this project is to empirically test the impact of E2 and P4 change on vulnerable brain networks associated with irritability and other depressive symptoms in female adolescents at risk of suicide. Participants: The investigators will enroll 50 female adolescents ages 12-16 who are at risk of suicide (i.e., moderate depressive symptoms), and are eligible to receive oral contraceptives and undergo MRI imaging. Procedure: Using a randomized, placebo-controlled, cross-over design, participants will be studied under two conditions: 8 weeks of E2 and P4 stabilization (continuous combined oral contraceptive (COC) to prevent perimenstrual withdrawal) and 8 weeks of placebo, with a 1-month washout after each condition. Each condition will include: 1) daily samples of E2 and P4 urinary metabolites, 2) daily symptom ratings(e.g., irritability, negative affect and suicidal thoughts and behaviors (STBs)), and 3) a neuroimaging session with MRI and magnetic resonance spectroscopy (MRS).

Начало: 01.06.2026 Край: 01.04.2029 Възраст: 12–16 г.

United States University of North Carolina, Chapel Hill NCT07544966

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Impact of Loss Aversion Messaging and Anticipated Regret for Inaction on Exercise Adherence in Older Adults

Mobility Disability Walking Difficulty

The goal of this clinical trial is to learn if messages focused on not losing the functional benefits of exercise can help older adults with walking difficulty continue to exercise regularly. The main questions it aims to answer are: Do these messages make people more likely to anticipate regretting it if they do not exercise? Does more anticipated regret make it more likely they will exercise more regularly? Researchers will compare two versions of messages to see if the content of these one of these message types is more effective than the other. Participants will complete a daily 5-minute at home exercise program for 4 months and complete regular online surveys to track their progress and report their feelings regarding regret.

Начало: 01.06.2026 Край: 01.07.2027 Възраст: от 65 г.

United States Milton S. Hershey Medical Center NCT07540052

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Model-Informed Precision Dosing of Tacrolimus in Pediatric Kidney Transplantation

Pediatric Kidney Transplantation

The purpose of this study is to develop a novel and applicable dosing algorithm that helps support the clinical decision to achieve tacrolimus levels within the optimal immunosuppression range despite sparse sampling in routine clinical practice in pediatric kidney transplantation. This clinical decision support tool (CDST) is based on a hybrid population pharmacokinetics-machine learning approach aiming for tacrolimus dose individualization and reducing the risk of acute graft rejection.

Начало: 01.06.2026 Край: 01.06.2027 Възраст: до 18 г.

Helwan University NCT07549230

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Evaluating the Integration Model of a Standalone Eye Centre Into Provincial Government Hospital

Health Services Ophthalmology Services Health Service Accessibility Eye Health Service Delivery

This study aims to evaluate the integration of a standalone eye centre into the Provincial Government Hospital in Kalaiya, Bara District, Nepal. The integration model seeks to improve access to comprehensive eye care services by combining the specialized expertise of an eye care facility with the infrastructure and patient flow of a provincial hospital. As the burden of avoidable visual impairment remains high in Nepal, strengthening service delivery at the district level has the potential to improve early detection, timely treatment, and continuity of care. 1 A mixed-method approach will be used to assess changes in service utilization patterns for example patient volume, follow ups and referrals following the integration. Additional focus will be placed on the acceptability of the integration model among patients, eye care professionals, and the hospital staff. This study will help to generate evidence-based recommendations to guide district-level planning for integrated eye care models by 2027. Data will be collected from patient records, hospital statistics, patient and staff interviews. The findings are expected to provide evidence on the feasibility, challenges, and benefits of integrating specialized eye care units into provincial hospital systems in low-resource settings. Ultimately, the study aims to inform policy decisions, support scalable models of eye care integration, and contribute to improved eye health outcomes for underserved populations.

Начало: 01.06.2026 Край: 01.12.2026 Възраст: от 18 г.

Seva Canada Society NCT07547527

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Deep Learning Framework for Continuous Depth of Anesthesia Forecasting

BIS BIS-EEG Artifical Intelligence Intraoperative +4

The integration of Artificial Intelligence (AI) in anesthesiology offers the potential to shift patient monitoring from reactive to predictive. Deep learning architectures, specifically Long Short-Term Memory (LSTM) networks, excel at processing complex, time-series data to forecast future clinical states. While standard PK/PD models (such as the state of the art Eleveld model for Propofol and Remifentanil) estimate target-site drug concentrations (Ce), they do not account for real-time, patient-specific dynamic responses. This study aims to deploy an AI framework designed to predict future physiological states.

Начало: 01.06.2026 Край: 01.09.2026

Belgium Universitair Ziekenhuis Brussel NCT07536230

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Peripheral Venous Pressure (PVP) Trial

Congestive Heart Failure

The purpose of the study is to determine if there is a reduction in the length of stay and rates of rehospitalization for patients diagnosed with congestive heart failure when physicians are provided daily measurements of peripheral venous pressure versus no daily measurements of peripheral venous pressure.

Начало: 01.06.2026 Край: 01.08.2031 Възраст: от 18 г.

United States Wake Forest University Health Sciences NCT07400042

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Healing Hearts of Hospitalized Patients

Well-Being, Psychological Anxiety Affect Relaxation

The study aims to evaluate the impact of a bedside-delivered virtual reality (VR) mindfulness experience on well-being and psychosocial outcomes among hospitalized adult patients compared to standard of care (SOC; no added mindfulness intervention).

Начало: 01.06.2026 Край: 31.05.2027 Възраст: 18–99 г.

United States Stanford University NCT06935604

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Clinical Decision Support to Increase Use of Medications for Opioid Use Disorder

Medication Abuse Harm Reduction Opioid Use Disorder Supportive Care

The objective of this study is to evaluate the impact of clinical decision support (CDS) in the form of an alert to identify patients who may be at risk of opioid use disorder (OUD) and a clinical care pathway helping providers treating patients with opioid use disorder. The pathway provides health care providers with information and suggestions for screening and treatment of opioid use disorder, including treatment with medications. The 2022 Centers for Disease Control and Prevention (CDC) clinical practice guideline for prescribing opioids for pain recommends providers asses for and treat opioid use disorder using approved medications for opioid use disorder (MOUD). This project will randomize primary care providers at the clinic level to a control arm or intervention arm. The control arm will have access to the clinical care pathway, but will not be reminded to utilize the pathway when treating a patient with opioid use disorder. The intervention arm will receive a reminder nudge about the pathway. Buprenorphine (a medication used to treat opioid use disorder) prescribing behavior of providers and outcomes of patients will be examined based on medical records data collected during routine care. The study period will be approximately 18 months.

Начало: 01.06.2026 Край: 01.05.2027 Възраст: 12–89 г.

University of Colorado, Denver NCT06526286

Предстои набиране Фаза 4

Lumbar Drain With Intrathecal Nicardipine in Aneurysmal Subarachnoid Hemorrhage

Subarachnoid Hemorrhage

The purpose of this study is to determine the effectiveness of prophylactic administration of intra-thecal nicardipine though lumbar cerebrospinal fluid drain in prevention of symptomatic vasospasm in patients with subarachnoid hemorrhage due to rupture of cerebral aneurysms.

Начало: 01.06.2026 Край: 01.01.2027 Възраст: от 18 г.

United States Wake Forest University Health Sciences NCT07246629

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Scalable Behavioral Program for Weight Loss Maintenance After GLP-1 and Anti-Obesity Medication Discontinuation

Weight Loss GLP - 1 Weight Loss Maintenance Obesity & Overweight

This study is a single-site, pilot randomized factorial trial designed to evaluate the feasibility, acceptability, participant perceptions and preliminary effects of a multi-component behavioral intervention to support weight loss maintenance following discontinuation of GLP-1 and other anti-obesity medications. The intervention includes a standardized 10-week foundational weight loss maintenance program combined with candidate support components, including medically tailored meals, YMCA membership, and a structured mind-based program. Participants will be randomized using a 2 × 2 × 2 factorial design and followed for six months. Findings from this pilot study will inform optimization of a scalable intervention for future clinical trials.

Начало: 01.06.2026 Край: 28.02.2029 Възраст: от 18 г.

United States University of Alabama at Birmingham NCT07535892

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Quantitative Analysis of Cardiac Muscle Perfusion

Myocardial Ischemia

Full quantitative perfusion of the myocardial wall using MRI is a difficult method for several reasons. First the perfusion algorithm is mostly only relatively available, usually available algorithms /e.g. ISP/ shows not precise results according to our measurements, secondly based on signal physics and nature of MRI scans is not easy to get absolute numbers and specific new algorithms must be developed and tested. Such a tool is not only needed for some special cohort of patients, like 3-vessel disease, coronary artery disease or diffuse coronary artery involvement in coronary vasculopathy in patients after heart transplantation. Fully quantitative perfusion analysis is highly needed for nearly all cardiac patients to better characterise the health and status of the myocardium.

Начало: 01.06.2026 Край: 30.12.2029 Възраст: от 18 г.

Czechia St. Anne's University Hospital Brno, Czech Republic NCT07548879

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Minimally Invasive Approaches for the Diagnosis of Barrett's Esophagus and Esophageal Cancer, SOS5C Trial

Barrett Esophagus Esophageal Adenocarcinoma

This clinical trial studies how well minimally invasive approaches (an artificial intelligence \[AI\] powered risk tool, nurse navigation, and a sponge on a string \[SOS\] test) work in diagnosing patients with Barrett's esophagus (BE) and esophageal cancer. Esophageal cancer has a poor 5-year survival rate when diagnosed after onset of symptoms. While rising, incidence of esophageal cancer remains too low to screen the entire population. BE is a condition in which the cells lining the lower part of the esophagus have changed or been replaced with abnormal cells that could lead to esophageal cancer. Currently, patients are screened for BE based on certain risk factors (reflux, age \> 50 years, White race, family history of esophageal cancer, obesity, male sex, and smoking), followed by endoscopies and surgery for treatment. These standard procedures may result in under-recognition of BE risk due to inaccurate and difficult to use risk assessment tools, high cost, invasiveness, low access to endoscopy, and sub-optimal recognition of abnormal cells during routing endoscopy. An AI powered risk tool that integrates symptoms, health history, and laboratory values from electronic health record data may more accurately assess BE and esophageal cancer risk that manual assessment. The BE-SOS screening test combines a swallowable cell collection device with assessment of DNA, which may more accurately diagnose abnormal cells. Nurse navigation involves trained personnel assisting individuals through the screening process and completing the follow-up diagnostic test if the screening test is positive. Navigators address cultural, social, access, and logistical barriers to screening. Nurse navigation may increase completion rates of diagnostic procedures following a positive screening test. These minimally invasive approaches may enable higher rates of BE screening than currently being accomplished.

Начало: 01.06.2026 Край: 31.07.2030 Възраст: 18–85 г.

United States Mayo Clinic NCT07206589

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Effect of Intraoperative Dexamethasone on Early Postoperative Sleep Quality in Patients Undergoing Nasal Surgery

Sleep Disturbance

This study aims to evaluate the effect of intraoperative dexamethasone on early postoperative sleep quality in adult patients undergoing nasal surgery under general anesthesia.

Начало: 01.06.2026 Край: 01.07.2027 Възраст: от 19 г.

Seoul National University Hospital NCT07550803

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