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Намерени 4,436 изпитвания Стр. 152 от 222

Набира участници Фаза 1/2

Phase 1/2 Study of IMC-R117C in Selected Advanced Cancers

Cancer HLA-A*02:01-positive

This phase 1/2 first-in-human study is designed to test the safety and efficacy of IMC-R117C (PIWIL1 × CD3 ImmTAC® Bispecific Protein) as a single agent and in combination with other therapies in HLA-A\*02:01-positive participants with selected advanced PIWIL1-Positive cancers.

Начало: 10.01.2024 Край: 30.11.2027 Възраст: от 18 г. Лечение

Australia, Belgium, Germany +3 Immunocore Ltd NCT06840119

Набира участници Фаза 2

Evaluation of a Keto-Like Supplement on Brain Responses to Emotional Stimuli in Depression

Depression

This study aims to determine whether a keto-like supplement relative to placebo results in functional brain changes during fMRI tasks evaluating positive and negative valence in individuals with moderate to severe depression. In this double-blind randomized placebo-controlled trial, 75 individuals with a Patient Health Questionnaire (PHQ-9) scale score ≥ 10 (MDD) will be enrolled to participate in an 8-week treatment study to obtain 60 completers. Participants will be randomized with a 1-1 ratio to receive the keto-like supplement (n= 30 completers) or placebo (n=30 completers) taken orally three times per day for 8 weeks. Participants will undergo a 10.5-hour screening/baseline evaluation visit split over 2 days at week 0 including questionnaires, neuroimaging before and after supplement or placebo administration and blood draws, office visits at week 2 (1.5 hours), week 4 (3 hours), week 6 (0.5 hours), week 8 (6 hours), a follow-up visit at week 10 (1.5 hours) and two phone calls between visits (weeks 1 and 3) during which a brief clinical assessment will be obtained (10 minutes each). The total time involved in the study is approximately 23.5 hours.

Начало: 09.01.2024 Край: 01.12.2027 Възраст: 18–65 г.

United States Laureate Institute for Brain Research, Inc. NCT06263660

Набира участници

The Validation Study of Bioelectronics

Healthy Health Behavior

The purpose of this study is to investigate the safe wearability and basic functions of the multi-modality sensors fabricated in the PI lab.

Начало: 09.01.2024 Край: 01.11.2026 Възраст: 18–99 г.

United States University of North Carolina, Chapel Hill NCT05397951

Набира участници

A Translational Study to Describe Clinical Characteristics, Biomarkers and to Identify Phenotypes and Endotypes Associated With Differential Outcomes in Chinese Population

Asthma

A Translational Study to Describe Asthma Patient Clinical Characteristics, Treatment Patterns, Biomarkers and to Identify Phenotypes and Endotypes associated with Differential Outcomes that may Support Future Development of Personalised Treatment Strategies in Chinese Population

Начало: 08.01.2024 Край: 08.10.2026 Възраст: 18–75 г.

China AstraZeneca NCT06419413

Набира участници

Effect of Nicotinamide Riboside on Ketosis, Fat Oxidation & Metabolic Rate

Overweight Obesity

Background: At least 30% of Americans have fatty liver disease. This means that they store too much fat in the liver. At the moment lifestyle changes are the only way to treat this problem. Objective: To test how (1) a low-carbohydrate diet and (2) a supplement called nicotinamide riboside (NR) affect how a person s body uses dietary fat. Eligibility: Men aged 18 to 65 and women aged 18 to 50 who are healthy volunteers with a body mass index (height to weight ratio) of 25 or more. Adults with maturity-onset diabetes of the young type 2 (MODY2) are also needed. Design: Participants with diabetes will have 1 screening visit and a 9-day clinic stay. Healthy volunteers will have 1 screening visit and 2 clinic stays of 1 to 2 weeks each. During screening, all participants will have a physical exam with blood and urine tests. They will have their heart rhythm measured while riding a gym bike. NR is a pill taken by mouth. Only healthy volunteers will take the NR, for 14 days at a time, during 1 clinic stay. During their other stay, they will take placebos; these are pills that look like the study supplement but contain no NR. During each clinic stay, all participants will eat a normal American diet. Then they will eat a ketogenic "low-carb" diet for 5 days. Participants will have many tests, including: Sleeping every night and having two 24-hour stays in a special room that measures the gases their body uses and produces. Drinking a high-fat shake, then remaining seated for 5 hours while their blood and breath are monitored. Having a substance injected into the arm and remaining seated for 3 hours while their blood is measured. Wearing monitors to measure their activity levels. Another monitor will measure their blood glucose levels. Having imaging scans. ...

Начало: 08.01.2024 Край: 31.01.2028 Възраст: 18–65 г.

United States National Institute of Diabetes and Digestive and Kidney NCT06044935

Набира участници

CRICKET: Critical Events in Anaesthetised Kids Undergoing Tracheal Intubation

Intubation Complication Adverse Events

The investigators' overall objective is to assess the incidence of critical events related to tracheal intubation at all international study sites. Furthermore, the study will investigate the used intubation techniques and identify possible improvement measures to increase patient safety.

Начало: 08.01.2024 Край: 01.12.2025 Възраст: до 16 г.

Australia, Canada, Germany +2 Thomas Riva NCT05804188

Набира участници

BioBrace® Implant for Arthroscopic Repair of Full Thickness Rotator Cuff Tears

Rotator Cuff Tears

This study aims to evaluate the safety and effectiveness of arthroscopic rotator cuff repair augmented with the BioBrace® Implant vs. arthroscopic rotator cuff repair alone in subjects requiring surgical intervention for a full-thickness rotator cuff tear.

Начало: 05.01.2024 Край: 01.06.2027 Възраст: 40–70 г.

United States CONMED Corporation NCT05997381

Набира участници

Quantifying Bone and Skin Movement in the Residual Limb of Individuals With Transtibial Amputation Using Dynamic Stereo X-Ray

Amputation, Lower Limb

Individuals with lower extremity amputation are often challenged by complications that arise from poor prosthetic fit, including movement of the residual limb in the socket, known as pistoning. Pistoning can lead to gait instability, skin problems, and pain. Different prosthetic suspension systems have been developed to decrease this motion, including elevated vacuum suspension, which utilizes a pump to draw air from the socket. However, scientific analyses to understand the movement between the limb and socket have yet to be performed with a high level of accuracy. This study will use a state-of-the art imaging technique, known as dynamic stereo x-ray, to quantify the 3D movement of the residual limb in the socket. It is hypothesized that dynamic stereo x-ray will be a sensitive method to measure differences in residual limb movement between 2 different socket suspension techniques: suction and elevated vacuum suspension. This information is critical for advancing prosthetic treatments to reduce secondary conditions and degenerative changes that result from poor prosthetic fit.

Начало: 05.01.2024 Край: 31.03.2027 Възраст: от 18 г.

United States VA Office of Research and Development NCT05287646

Набира участници Фаза 3

A Study to Provide Continued Access to and Assess Long-Term Safety of the Study Drug(s)

Advanced Cancer Metastatic Cancer

This open-label, multicenter, rollover study will provide continued treatment for participants deriving benefit from different therapies received in studies sponsored by Daiichi Sankyo, Inc. (DS) or DS/Astra Zeneca (AZ)-sponsored study (eg. DS8201-A-J101, DS8201-A-U201, DS8201-A-U204, DS8201-A-U207, DS8201-A-U303).

Начало: 05.01.2024 Край: 17.01.2028 Възраст: от 18 г. Лечение

Australia, Belgium, Brazil +9 Daiichi Sankyo NCT06174987

Набира участници

A Global Study of the PETAL Consortium

T-Cell and NK-Cell Neoplasm

The goal of this observational study is to correlate molecular alterations with outcomes including overall survival (OS), progression-free survival (PFS), response rates for patients with a new diagnosis, primary refractory or relapse, of mature T-cell and NK-cell neoplasms (TNKL). We hypothesize that machine learning can be leveraged to uncover distinct genetic vulnerabilities that underlie treatment response and resistance for patients with TNKL, thus moving towards personalized treatment solutions.

Начало: 05.01.2024 Край: 01.01.2028 Възраст: от 18 г.

Australia, Japan, South Africa +1 Massachusetts General Hospital NCT06067347

Набира участници Фаза 1/2

PrProfile: A Study to Assess the Safety, Tolerability, Pharmacokinetics and Pharmacodynamics of ION717

Prion Disease

The purpose of this study is to evaluate the safety, tolerability, pharmacokinetics and pharmacodynamics of intrathecal (IT) delivery of ION717.

Начало: 04.01.2024 Край: 01.06.2030 Възраст: от 18 г. Лечение

Australia, Canada, France +6 Ionis Pharmaceuticals, Inc. NCT06153966

Набира участници Фаза 1

A Study to Evaluate INCB161734 in Participants With Advanced or Metastatic Solid Tumors With KRAS G12D Mutation

Solid Tumors

This study is conducted to determine the safety and tolerability of INCB161734 as a single agent or in combination with other anticancer therapies.

Начало: 04.01.2024 Край: 01.01.2027 Възраст: от 18 г. Лечение

Australia, Belgium, Canada +5 Incyte Corporation NCT06179160

Набира участници Фаза 2

Testing the Anti-cancer Drug Erdafitinib for Brain Cancers That Have Returned or Progressed Following Treatment

Recurrent Glioma Recurrent WHO Grade 2 Glioma Recurrent WHO Grade 3 Glioma Recurrent WHO Grade 4 Glioma

This phase II trial tests how well erdafitinib works in controlling IDH-wild type (WT), FGFR-TACC gene fusion positive gliomas that have come back after a period of improvement (recurrent) or that are growing, spreading, or getting worse (progressive). Erdafitinib is in a class of medications called kinase inhibitors. It works by blocking the action of an abnormal FGFR protein that signals tumor cells to multiply. This may help keep tumor cells from growing and may kill them. Giving erdafitinib may help to slow the growth of, or to shrink, tumor cells in patients with recurrent or progressive IDH-wild type gliomas with FGFR-TACC gene fusion.

Начало: 04.01.2024 Край: 23.10.2026 Възраст: от 18 г.

United States National Cancer Institute (NCI) NCT05859334

Набира участници Фаза 1

Study to Assess the Safety, Tolerability, and Blood Concentration of PMC-309

Advanced or Metastatic Solid Tumors

This is a Phase 1a/1b, first-in-human (FIH), open label study to evaluate the safety, tolerability, and pharmacokinetics (PK) of PMC-309, a mAb against the human VISTA ligand, in participants with advanced or metastatic solid tumors administered as a monotherapy and in combination with pembrolizumab.

Начало: 03.01.2024 Край: 30.04.2030 Възраст: от 18 г. Лечение

Australia PharmAbcine NCT05957081

Набира участници

Anxiety and Surgery Satisfaction for Cataract Patient With Different State Anxiety

Oral Anxiolytic Phacoemulsification Cataract Surgery Satisfaction Survey +1

This study aims to explore the effects of anxiety traits on pain, anxiety, and anesthesia satisfaction in patients undergoing cataract surgery under topical anesthesia. On the day of recruitment, patients will complete the BAI, STAI-S, and STAI-T anxiety questionnaires to assess baseline anxiety levels. Thirty minutes before the surgery, patients will be randomly assigned, in a double-blind manner, to receive either Xanax or a placebo and will retake the BAI, STAI-S, and STAI-T questionnaires. After the surgery, patients' pain levels and anesthesia satisfaction will be evaluated, with the pain scale and satisfaction survey repeated the following day. The results will analyze the relationship between anxiety traits and pharmacological interventions on the surgical experience, aiming to optimize surgical procedures and improve overall patient comfort.

Начало: 02.01.2024 Край: 31.12.2026 Възраст: 18–80 г.

Taiwan National Taiwan University Hospital NCT06826417

Набира участници

DINO RCT - Treating Anxiety in Children With Autism

Autism Spectrum Disorder Anxiety Disorders

Anxiety is prevalent in young children, under 7 years of age, with autism. Yet, few studies have examined anxiety interventions for this age range, and only one anxiety treatment study has included young children with cognitive and language delays. Anxiety treatment models utilizing cognitive-behavioral therapy (CBT), adapted for children with autism, are empirically supported in school-age autistic children. Further, preliminary evidence suggests CBT approaches may reduce intolerance of uncertainty (IU), a mechanistic construct that may contribute to the maintenance of anxiety in autistic children. This study seeks to address the existing gap in anxiety treatment by examining the feasibility and preliminary efficacy of a novel, telehealth CBT intervention, DINO Strategies for Anxiety and intolerance of Uncertainty Reduction (DINOSAUR), which targets both anxiety and IU in young autistic children.

Начало: 02.01.2024 Край: 15.10.2026 Възраст: 4–6 г.

United States Hugo W. Moser Research Institute at Kennedy Krieger, In NCT06066983

Набира участници

Clonal Hematopoiesis and Therapy-Emergent Myeloid Neoplasms in Patients With Cancers, CHANCES Study

Recurrent Fallopian Tube Carcinoma Recurrent Ovarian Carcinoma Recurrent Primary Peritoneal Carcinoma Recurrent Malignant Solid Neoplasm +6

This study is being done to investigate clonal hematopoiesis and therapy-emergent myeloid neoplasms in patients with ovarian or other solid cancers. Researchers want to identify risk factors for developing these blood cancers as well as if there is/are a genetic/environmental component(s) to developing blood cancer.

Начало: 02.01.2024 Край: 31.12.2031

United States University of Washington NCT06295965

Набира участници

Association Between Radial Artery Intervention and Development of Neuropathy in the Hand - A Prospective Study

Ischemic Heart Disease Nerve Injury Carpal Tunnel Syndrome

Evaluation of potential nerve damage after radial CAG/PCI.

Начало: 01.01.2024 Край: 01.12.2028 Възраст: от 18 г.

Denmark Aarhus University Hospital Skejby NCT05365282

Набира участници

Post-Debonding Finishing in Orthodontics

Caries Enamel Lesions

This study investigates clinical approaches to orthodontic debonding and post-debonding finishing, focusing on enamel preservation. An observational epidemiological survey was conducted among dental professionals to assess commonly used techniques, instruments, and complications. Results highlight variability in clinical protocols, with mechanical methods being the most widely adopted. The study emphasizes the importance of minimally invasive strategies to reduce enamel damage and improve patient outcomes.

Начало: 01.01.2024 Край: 01.06.2026

Italy University of Roma La Sapienza NCT07534423

Набира участници

Emergency Medicine Pulmonary Embolism Testing Multicentre Study

Pulmonary Embolism D-dimer Diagnosis

It is important to diagnose pulmonary embolism in a timely manner to prevent death and long-term disability. More than half a million people (4-5% of emergency department patients) are tested for pulmonary embolism, although the positive rate is low. Imaging for PE testing exposes patients to radiation, is expensive, adds time to the emergency visit, and can lead to a false positive diagnoses. Existing protocols aimed at reducing unnecessary pulmonary embolism imaging are complex and seldom used by emergency physicians. Too many patients undergo unnecessary pulmonary embolism imaging. A new tool (called Adjust-Unlikely) could safely reduce pulmonary embolism imaging in Canada. A research group composed of researchers, emergency physicians, and patients developed the Adjust-Unlikely clinical decision rule: a rule which has been customized for emergency physicians and emergency patients. Adjust-Unlikely is highly sensitive at the bedside, meaning there are very few false negative results. The study aim is to prospectively validate Adjust-Unlikely pulmonary embolism testing in emergency patients with suspected pulmonary embolism.

Начало: 01.01.2024 Край: 30.09.2027 Възраст: от 18 г.

Canada Dr. Kerstin de Wit NCT06320236

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