Search trials – HealthDB

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Намерени 4,781 изпитвания Стр. 151 от 240

Not yet recruiting

Effects of Music During Walking on Pain and Muscle Activation in People With Chronic Pain Due to Knee Osteoarthritis

Knee Osteoarthritis

The purpose of this research study is to compare muscle activation, changes in pain sensitivity, and brain function, between different walking conditions, including walking to music, walking to metronome, and walking without music or metronome.

Начало: 01.08.2026 Край: 01.07.2027 Възраст: 50–85 г.

Boston University Charles River Campus NCT07537114

Not yet recruiting

Investigation of Imagery Abilities in Individuals With Migraine

Migraine Healthy Participants

The aim of this study is to compare the motor imagery abilities of patients with migraine to those of healthy individuals, and to examine the relationship between motor imagery and proprioception (cervical and trunk), balance, body awareness, anxiety, and depression levels. Additionally, the study aims to investigate the relationship between proprioception and balance in patients with migraine. Motor imagery abilities of patients with migraine and healthy control subjects (aged 18-65 years; planned sample size: 68 individuals in each group, 68 migraine patients and 68 healthy participants) will be assessed using the Movement Imagery Questionnaire-3, the Motor Imagery Ability Test, mental chronometry, mental rotation tasks, and functional MRI (fMRI) during motor imagery of different tasks. Additionally, in patients with migraine, cervical and trunk proprioception, balance, body awareness, the Tampa Scale for Kinesiophobia, the Vertigo Symptom Scale, the Dizziness Handicap Inventory, and the Hospital Anxiety and Depression Scale will be evaluated. 1. Hypothesis H0: There is no difference in motor imagery abilities between patients with migraine and healthy controls. H1: There is a difference in motor imagery abilities between patients with migraine and healthy controls. 2. Hypothesis H0: There is no relationship between motor imagery abilities and proprioception in patients with migraine. H1: There is a relationship between motor imagery abilities and proprioception in patients with migraine. 3. Hypothesis H0: There is no relationship between proprioception (cervical/trunk) and balance in patients with migraine. H1: There is a relationship between proprioception (cervical/trunk) and balance in patients with migraine. 4. Hypothesis H0: There is no relationship between motor imagery abilities and body awareness, anxiety, and depression in patients with migraine. H1: There is a relationship between motor imagery abilities and body awareness, anxiety, and depression in patients with migraine.

Начало: 01.08.2026 Край: 30.08.2027 Възраст: 18–65 г.

Hacettepe University NCT07546201

Not yet recruiting

Evaluation of a Novel Indoor Air Pollution Intervention Among Older Adults

Cardiovascular Diseases Blood Pressure Glycated Hemoglobin (HbA1c) Cholesterol +5

Particulate matter air pollution is the leading environmental risk factor of cardiovascular disease and is increasing in the Western United States due to more frequent and severe wildfires. Older adults are particularly susceptible to both air pollution exposures and the development of cardiovascular disease, and the older adult population in the United States is rapidly growing. Given the converging threats of worsening air quality and an aging population, this clinical trial will evaluate a novel, multifaceted indoor air quality intervention to improve cardiovascular health outcomes among older adults in the wildfire-impacted state of Montana.

Начало: 01.08.2026 Край: 01.07.2030 Възраст: 55–79 г.

United States University of Montana NCT07539987

Not yet recruiting

Evaluating the Implementation Via Audit and Feedback

Hypertension Diabetes

The ability of primary healthcare (PHC) providers to practice in accordance with evidence-based guidelines and norms is a critical component of improving the quality of primary healthcare. Implementation science seeks to promote the routine use of evidence-based practices by identifying barriers to their implementation and developing strategies, such as audit and feedback (AnF), to overcome them. However, because the effects of AnF show significant heterogeneity across studies, this research focuses on systematically developing an optimized AnF strategy and rigorously evaluating its effectiveness in improving clinical practice compared to no intervention. The development of an optimized AnF strategy involves a preparation phase, which utilizes expert consultation and a Best-Worst Scaling (BWS) survey to identify key candidate components and assess resource constraints, followed by an optimization phase utilizing a 2×2×2×2 factorial design randomized controlled trial (RCT) to determine the most effective combination of AnF components. Subsequently, in the evaluation phase, a two-arm, multicentre RCT will be conducted across four nations (Nepal, Mozambique, Tanzania, and China). Primary healthcare providers (PHPs) will be 1:1 randomly assigned to either the optimized AnF intervention group or a no intervention control group based on randomly permuted blocks (sizes 2, 4, and 6), stratified by country. Care quality will be assessed using the gold standard method of Unannounced Standardized Patients (USPs). The primary outcome is the proportion of completed guideline-recommended quality checklist items for the consultation of hypertension and Type II diabetes cases among all items. This outcome will be expressed as a continuous score ranging from 0% to 100%. Furthermore, a mixed-methods research strategy will be employed to extract Context-Mechanism-Outcome (CMO) elements and construct a Causal Pathway Diagram (CPD). This study will provide a robust empirical foundation for using an optimized AnF strategy to improve the quality of primary healthcare in developing countries. By deconstructing "why, for whom, and under what circumstances" the intervention works through the CMO framework and CPD, this study will provide vital mechanistic evidence for the future scale-up of this model, contributing a comprehensive and universal research paradigm to the field of implementation science.

Начало: 01.08.2026 Край: 01.12.2027

Southern Medical University, China NCT07542587

Not yet recruiting

The EDICT Trial - Therapy for Inflammatory Bowel Disease Flares

Inflammatory Bowel Disease

Inflammatory bowel disease (IBD), including Crohn's disease (CD) and ulcerative colitis (UC), are chronic inflammatory conditions of the gastrointestinal tract that affect millions of people in the United States of America. Among patients with IBD, symptomatic flares are quite common; up to 40-50% of patients in some populations report having a flare at least once per month. For most patients with IBD flares, the typical outpatient treatment consists of corticosteroids and, in some instances, initiation of or switching between 5-aminosalicylic acid-acid preparations, immunomodulators, or biologics. These treatments, while often effective, can have harmful side effects, especially when used for long durations of time. Therefore, alternative treatments are highly sought after by both patients and providers.

Начало: 01.08.2026 Край: 01.12.2026 Възраст: от 21 г.

United States Wake Forest University Health Sciences NCT07143188

Not yet recruiting Phase 4

Liposomal Bupivacaine vs Perineural Adjuvants in Adductor Canalf and iPACK Blocks in Total Knee Arthroplasty

Knee Arthroplasty, Total

The purpose of this research study is to compare two different combinations of anesthetic medications to see which works the best in providing the longest lasting pain relief for total knee arthroplasty surgery. The drugs being used are liposomal bupivacaine compared to a combination of bupivacaine, clonidine, epinephrine, buprenorphine, and dexamethasone. Pain scores will be collected at different intervals during study participation.

Начало: 01.08.2026 Край: 31.12.2026 Възраст: от 18 г.

United States Wake Forest University Health Sciences NCT07097493

Not yet recruiting

Comparing Yoga Nidra, Yoga, and Control Condition on Pain in Individuals With Chronic Low Back Pain

Low Back Pain

Individuals with chronic low back pain will undergo a yoga, yoga nidra, and control condition on separate visits. Each visit, before and after the intervention, participants with rate their pain in response to heat stimuli, a sit to stand task, and questionnaires.

Начало: 01.08.2026 Край: 01.07.2027 Възраст: 18–65 г.

United States University of Central Florida NCT07543835

Not yet recruiting

Ameliorating Stroke-induced Hemianopia Via Multisensory Training

Hemianopia, Homonymous Cortical Blindness, Unspecified Side of Brain

This study seeks to determine the extent of the visual capabilities that can be restored in hemianopic stroke patients by a multisensory training technique and evaluate changes in the brain that the training induces. The effectiveness of the technique will be evaluated in two interventional contexts: patients whose blindness is long-standing and stable, and another in which intervention is as soon as possible after the stroke.

Начало: 01.08.2026 Край: 01.07.2027 Възраст: от 18 г.

United States Wake Forest University Health Sciences NCT05894434

Not yet recruiting Phase 3

Study Evaluating the Efficacy of KITE-753 Versus Axicabtagene Ciloleucel in Participants With Relapsed or Refractory Large B-Cell Lymphoma After First-Line Therapy

Relapsed or Refractory Large B-cell Lymphoma

The goal of this clinical study is to compare the study drug KITE-753 versus axicabtagene ciloleucel (axi-cel) in adult participants with relapsed or refractory (r/r) large B-cell lymphoma (LBCL) after one prior line of therapy. The primary objective of this study is to evaluate the efficacy of KITE-753 versus axicabtagene ciloleucel.

Начало: 01.08.2026 Край: 01.05.2031 Възраст: от 18 г.

Kite, A Gilead Company NCT07479797

Not yet recruiting

Emotional Brain Training for Addiction Medicine Treatment - A Pilot Study

Cannabis Use Disorder Stimulant Use Disorder Opioid Use Disorder Tobacco Use Disorder +2

The goal of this clinical trial is to determine whether Emotional Brain Training (EBT), a behavioral modification method, can help manage stress and health problems related to addiction. EBT teaches skills to deactivate harmful circuits (automatic reactions) and activate healing circuits to quickly shift mood from negative to positive. Participants in the EBT group will receive focused, intensive instruction on using these skills to rewire unwanted brain circuits, with the aim of achieving lasting improvements in emotional health and quality of life. The study will assess whether EBT is an effective tool when added to standard of care (SOC), which includes medications for addiction treatment (MAT). Researchers will compare changes in stress, anxiety, and cravings after 8 weeks of EBT plus SOC versus SOC alone. Participants: * will either continue receiving standard treatments (SOC) at the Addiction Recovery Clinic (ARC) at SAC Health in San Bernardino * or receive both EBT and SOC at ARC * in the SOC group will continue monthly visits at ARC and weekly counseling * in the EBT plus SOC group will continue monthly visits and weekly counseling at ARC, along with weekly EBT group sessions by telephone * will complete online assessments at weeks 0, 4, and 8 Upon completion of the study, all participants will resume SOC

Начало: 01.08.2026 Край: 01.08.2027 Възраст: от 18 г.

United States Loma Linda University NCT07001371

Not yet recruiting

Integrating Supports to Promote PrEP for Black Adolescents Working With Apps- Atlanta

HIV Infections

This study applies Social Cognitive Theory to develop behavioral interventions promoting PrEP adherence. It seeks to adapt and test the enhanced HMP app for feasibility and acceptability among Black adolescents and young adults (AYAs) and adult supports.

Начало: 01.08.2026 Край: 01.04.2027 Възраст: 14–21 г.

United States Emory University NCT07535346

Not yet recruiting

Total Arterial vs. Mixed Grafting in Left Coronary CABG

Coronary Artery Disease Coronary Artery Bypass Grafting Arterial Graft Graft Patency +1

This is a prospective, randomized, double-blind controlled trial comparing the clinical efficacy of total arterial grafting (internal thoracic artery and radial artery) versus conventional mixed grafting (internal thoracic artery and great saphenous vein) in the left coronary artery system during coronary artery bypass grafting (CABG). A total of 400 patients undergoing elective CABG at the Second Hospital of Jilin University will be enrolled and randomized into two groups. The primary endpoint is graft patency at 12 months postoperatively, evaluated by coronary angiography or CT angiography. Secondary outcomes include perioperative complications, major adverse cardiovascular events (MACE), and long-term clinical prognosis. The study aims to provide evidence-based guidance on optimal graft selection in CABG.

Начало: 01.08.2026 Край: 30.12.2027 Възраст: 18–80 г.

China Second Hospital of Jilin University NCT07057713

Not yet recruiting

Real World Evidence of SI-BONE's iFuse TORQ TNT Advancing Treatment of Pelvic Ring Fractures

Fracture; Pelvic Insufficiency Fractures Fragility Fracture Sacroiliac; Fusion +2

The purpose of this study is to evaluate outcomes in patients treated with iFuse TORQ TNT for pelvic fragility fractures.

Начало: 01.08.2026 Край: 01.08.2028 Възраст: от 60 г.

SI-BONE, Inc. NCT07530497

Not yet recruiting

Integration of Adaptive Proton Therapy in Pediatric Solid Tumors and Hodgkin's Lymphoma

Pediatric Solid Tumors Rhabdomyosarcoma Ewing Sarcoma Osteosarcoma +3

Pediatric patients receiving proton therapy for solid tumors or Hodgkin's lymphoma may experience anatomical changes during treatment that can affect proton therapy accuracy. This prospective single-arm study uses regular low-dose imaging to monitor these changes and adjust treatment plans as needed. Participants will receive weekly or every-other-week CT scans, with MRI when appropriate, to assess whether the original plan remains accurate. Treatment plans will be updated if tumor coverage decreases by more than 5% or if radiation dose to normal tissues increases by more than 10%; otherwise, the original plan will continue. The study aims to determine how often plan adjustments are needed and to identify which disease sites are most likely to experience significant anatomical changes during treatment. Primary Objective: * Define the frequency of replanning necessary to ensure tumor coverage never falls below 95% (or 5% drop) of the prescribed daily dose in participants with intact (gross) tumors to keep the tumor control optimal throughout the multi-week treatment regimen. * Define the frequency of replanning necessary to ensure organs-at-risk (critical organs) do not deviate by more than 10% of the initially approved dose constraints to keep the normal tissue complication minimal throughout the multi-week treatment regimen. Secondary Objectives * Establish a cone beam CT (CBCT)-based framework for quantifying body surface changes throughout the treatment course. This goal will be achieved by developing a novel algorithm that detects and tracks external anatomical variations longitudinally, without requiring CBCT image enhancement, enabling precise assessment of daily participant setup consistency and anatomical stability. * Overcome daily CBCT quality limitations by generating synthetic CT images that accurately represent daily anatomy and support proton dose recalculation or verification planning. This goal will be achieved by developing a hybrid pipeline that integrates deep learning models with the deformable image registration algorithm, trained and validated on disease site-specific data. This will enable precise dose mapping and tissue density estimation, directly supporting adaptive planning decisions without the need of diagnostic- quality CT images.

Начало: 01.08.2026 Край: 01.08.2031

United States St. Jude Children's Research Hospital NCT07514819

Not yet recruiting Phase 2

A Study to Evaluate Pharmacokinetics, Safety, Tolerability, Immunogenicity and Pharmacodynamic Effects of Subcutaneous Ocrelizumab Administration in Children and Adolescents With Relapsing-remitting Multiple Sclerosis (RRMS)

Relapsing-remitting Multiple Sclerosis

The main purpose of this study is to evaluate the pharmacokinetics (PK) of ocrelizumab administered subcutaneously (SC) in children and adolescents aged 10 to \

Начало: 01.08.2026 Край: 01.08.2031 Възраст: 10–17 г.

Hoffmann-La Roche NCT07503340

Not yet recruiting

MRI Evaluation of Graft Maturation Following ACL Reconstruction

ACL Tears

Post-surgical ACL Graft maturation will be assessed at 4.5, 6, 7.5, 9, 10.5, and 12 months with MRI.

Начало: 01.08.2026 Край: 01.02.2028 Възраст: 14–50 г.

United States Skye Biologics Holdings, LLC NCT07046000

Not yet recruiting

Integrating Supports to Promote PrEP for Black Adolescents Working With Apps- Alabama

HIV

Начало: 01.08.2026 Край: 01.08.2027 Възраст: 14–21 г.

United States Emory University NCT06876324

Not yet recruiting

Feasibility and Acceptability of an LLM-based Chatbot for Family Caregivers: Evaluation Study

Caregivers

This study evaluates the feasibility and acceptability of using the artificial intelligence (AI) chatbot mobile application (an LLM-based Chatbot) to support the well-being of informal care partners of individuals with traumatic brain injury (TBI), dementia, or Huntington disease (HD). Over an 8-week intervention period, up to 60 care partners will engage with the application (app), spending four weeks focusing on physical health and four weeks focusing on mental health. Participants will complete surveys at the midpoint and end of the intervention period. Participants will also complete a semi-structured interview to discuss participants experience using an LLM-based Chatbot. The study team hypothesizes that care partners will find the chatbot acceptable and feasible to use in daily life, and that there will be low attrition and high completion rates of the study.

Начало: 01.08.2026 Край: 30.06.2027 Възраст: от 18 г.

United States University of Michigan NCT07280650

Not yet recruiting

Evaluation of Clinical Decision Support in Opioid Tapering

Medication Abuse Harm Reduction Opioid Use Disorder Opioid Prescribing +2

The 2022 Center for Disease Control and Prevention (CDC) clinical practice guideline for prescribing opioids for pain recommends that when tapering a patient's opioid dose, doses should be decreased at a slow rate to reduce the risk of withdrawal symptoms, overdose, and to promote tolerance of the tapering. This project will evaluate a clinical decision support (CDS) tool in the form of a clinical care pathway that gives providers information, recommendations, and educational material on strategies for opioid tapering. Primary care providers will be randomized at the clinic location to a control arm or intervention arm. The control arm will have the clinical care pathway available, but will not be reminded of the pathway when tapering a patient. The intervention arm will receive a nudge when prescribing a tapering opioid strategy to a patient to use the clinical care pathway. The rate of opioid tapering in line with CDC guidelines will be examined as well as long-term patient outcomes of opioid overdose or poisoning using existing patient health records. The study period will be approximately 18 months.

Начало: 01.08.2026 Край: 01.06.2027 Възраст: 12–89 г.

University of Colorado, Denver NCT06527079

Not yet recruiting

Weight Loss Goals and Satisfaction Survey

Overweight and Obesity

The goal of this observational survey pilot study is to learn how 3D visualization tools (i.e., personalized avatars) influence weight loss goals, satisfaction, confidence, and commitment compared to numerical weight outcomes in weight loss-seeking adults. The main questions it aims to answer are: 1. What are contemporary weight loss goals (defined as dream, happy, acceptable, and disappointing weight loss outcomes), and how do they compare to goals reported in prior studies? 2. Does presenting weight loss outcomes using personalized 3D avatars result in different levels of satisfaction compared to presenting equivalent outcomes numerically as body weight? 3. Do predictive 3D avatars affect participants' confidence and commitment to achieving weight loss differentially than numerical weight loss goals? Researchers will compare visual (3D avatar-based) weight loss outcomes to numerical (pounds lost) weight loss outcomes to see if visual presentation lowers satisfaction with potential weight loss and alters confidence and commitment. Participants will: * Complete a one-time online survey * Provide demographic and self-reported anthropometric information to generate personalized 3D avatars * Report weight loss goals and rate satisfaction with potential weight loss outcomes shown numerically and as 3D avatars. * Complete questionnaires assessing psychological and behavioral weight-related factors.

Начало: 01.08.2026 Край: 01.09.2026 Възраст: от 18 г.

Pennington Biomedical Research Center NCT07541872

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