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Integrating Care for Hypertension-Diabetes MULTImorbidity in Guatemala Through HEARTS Implementation

Hypertension (HTN) Type 2 Diabetes

The purpose of this study is to find out whether a program called HEARTS can improve care for people who have both high blood pressure and diabetes. HEARTS was created by the World Health Organization to help primary care clinics deliver better treatment. It includes training for health workers, simpler treatment guides, better access to medicines, teamwork among clinic staff, and tracking systems to monitor patient care. In this study, 36 public primary care clinics in Guatemala will be randomly assigned to either use the HEARTS program or continue with their current care. About 1,440 adults who have both high blood pressure and diabetes will take part. Participants will be assessed at the start of the study and again after 12 months. The main measures are blood pressure and hemoglobin A1c (a blood test that shows average blood sugar levels over the past 2 to 3 months).

Начало: 01.05.2027 Край: 01.05.2030 Възраст: от 18 г.

University of Michigan NCT07536919

Предстои набиране

SunBeast: Evaluating UV Protective Behaviors and Education Interventions Among Ultrarunners

Sun Protection

Participants will be randomly assigned to either the intervention or control group using concealed allocation. The intervention-comprising targeted educational materials and behavioral prompts-will be delivered over three months preceding race day. All study participants will be required to complete the pre-race survey prior to the intervention. The intervention group will complete the SunBeast Educational module once and receive monthly reinforcement messages leading into race day. The SunBeast Educational Program module consists of a 30-minute live, interactive online discussion and infographics/videos on skin cancer, UV index awareness, sunscreen use, protective clothing, and timing of runs. The control group will receive a general wellness brochure via email. The general wellness brochure will contain UV protection information but will also have other general wellness topics.

Начало: 01.05.2027 Край: 01.05.2027 Възраст: от 18 г.

United States University of Michigan Rogel Cancer Center NCT07481344

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A Randomized Controlled Trial of a Smartphone Delivered Treatment for Suicidal Thoughts and Behavior

Suicidal Ideation Suicide Attempt

This study aims to evaluate the acceptability, safety, and efficacy of a smartphone-delivered intervention called Therapeutic Evaluative Conditioning for Suicide (TEC-S) in reducing suicidal thoughts and behaviors (STB) among adults with recent and frequent suicide ideation.

Начало: 01.04.2027 Край: 31.08.2029 Възраст: от 18 г.

United States Massachusetts General Hospital NCT06686901

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rTMS for Aneroxia Nervosa in Youth

Anorexia Nervosa

This study will examine the feasibility of off-label multilocus repetitive transcranial magnetic stimulation (rTMS) for symptoms of Anorexia Nervosa in participants between the ages of 14-24. rTMS is a non-invasive, brain-based intervention that uses magnets to deliver energy to the brain. The investigators will also see if patients receiving multilocus rTMS show any improvements in their eating disorder, mood, anxiety, and obsessions and compulsions (if present). Participants will receive daily intervention with off-label multilocus rTMS for 20 total treatments. Participants will also be asked to complete mental health and well-being surveys, physical measurements, and 2 brain imagining scans (MRIs) at baseline, and at study end. The investigators will also ask participants to complete surveys are 1-month and 3-months after the final rTMS session. The target enrollment for this study is 45 participants.

Начало: 30.01.2027 Край: 01.01.2030 Възраст: 14–24 г.

University of California, Los Angeles NCT04846517

Предстои набиране Фаза 1/2

A Phase I/II Study of PDC-1421 for Treating Depression in Cancer Patients

Major Depressive Disorder

The purpose of this study is to evaluate the safety and the effective doses of PDC-1421 in cancer patients with depression.

Начало: 15.01.2027 Край: 28.02.2028 Възраст: 21–85 г.

United States BioLite, Inc. NCT03833206

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OSCAR II STUDY - The ONCObind CTC Removal Study

Pancreatic Ductal Adenocarcinoma (mPDAC) Metastatic Colorectal Carcinoma (mCRC)

This study is a Prospective Single Arm, dual cohort Open Label Feasibility trial to evaluate the initial safety and signal of efficacy of a novel extracorporeal blood purification (EBP) procedure in either mPDAC or mCRC refractory to systemic therapy. Site selection will be dependent upon the site's familiarity with extracorporeal blood purification platforms as well as the diagnosis and management of mPDAC and mCRC. Adults (18 years old and older, ECOG PS of equal or less than 2) with a diagnosis of either mPDAC as defined histologically (microscopically) as a "pancreatobiliary type" adenocarcinoma who experienced disease progression or not tolerating fluoropyrimidine-, oxaliplatin- and irinotecan- based regimens or prior treatment with gemcitabine and nab-paclitaxel or are not candidates for chemotherapy or mCRC patients who experienced disease progression on 5-fluorouracil (5-FU), capecitabine, oxaliplatin and irinotecan as FOLFIRI and/or FOLFOX and/or XELOX and/or XELIR and/or FOLFOXIRI/FOLFIRINOX or who are not candidates for chemotherapy with at least 5 cells/mL CTCs in peripheral blood and/or portal vein.

Начало: 15.01.2027 Край: 01.07.2028 Възраст: от 18 г.

ExThera Medical Corporation NCT06655142

Предстои набиране Фаза 1

Preliminary Evaluation of the Safety and Tolerability of SPOT-mRNA01 Subcutaneously Administered in Healthy Subjects

Skin Aging

This is a first-in-human, randomized, double-blind, placebo-controlled clinical study to evaluate the Safety and Tolerability of SPOT-mRNA01 injection in healthy adult volunteers.

Начало: 11.01.2027 Край: 12.02.2029 Възраст: 18–75 г.

SIPO Biotechnology Co. Ltd. NCT06567119

Предстои набиране Фаза 4

Efficacy of Zoster Vaccination in Glioblastoma Patients

Glioblastoma (GBM)

In modern practice a trimodality treatment has emerged as standard of care for histologically confirmed glioblastoma. We hypothesize that the additional vaccination against herpes zoster, after surgical resection followed by irradiation therapy and chemotherapy of patients with glioblastoma will lead to a superior local control, overall and progression free survival. In an additional experimental setting based on patient preference the immunological effectiveness of the adoptive transfer of autologous polyclonal cytomegalovirus (CMV) specific T cells will be examined.

Начало: 02.01.2027 Край: 31.12.2030 Възраст: от 18 г.

University Hospital, Essen NCT07546669

Предстои набиране Ранна Фаза 1

The MIND Study: The MGH/MIT Investigation of NAC on Dysregulation

Emotional Dysregulation

This is a double-blind randomized controlled study. The study will last up to 16 weeks from the initial phone screen (it could take up to eight weeks to schedule and complete the initial screening process and schedule the 2 MRI visits). Once subjects have completed the screening process, they will begin the 8-week trial phase. Subjects will be assessed weekly throughout the study for efficacy and tolerability. The investigators plan to recruit 80 participants with emotional dysregulation (ED) in the treatment arm. In addition, the investigators will aim to recruit 40age-, sex-, and parental-education matched participants without emotional dysregulation, and major psychopathology as Typically Developing (TD) control participants in the control arm. Upon scheduling the baseline visit, only the emotional dysregulation (ED) participants will be randomized 1:1 to be exposed to NAC or placebo treatment for 8 weeks. Participants will complete baseline and post-treatment (endpoint) brain MRI acquisition. TD participants will complete the same screening and characterization process as the ED group and then will be invited to complete MRI eligibility screening and to be scanned twice, separated by an eight-week interval, but the TD will not complete the NAC treatment or receive a placebo. See Table 1 (Study Schema) for a complete list of characterization measures to be completed by each group.

Начало: 01.01.2027 Край: 01.01.2030 Възраст: 6–12 г.

United States Massachusetts General Hospital NCT07323446

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Open Label Trial of Deceased Donor Livers Transplanted After DHOPE With eXVIVO LIVER Perfusion

Liver Transplant Surgery Liver Transplantation

The purpose of this clinical study is to confirm the safety and effectiveness of dual hypothermic oxygenated perfusion (DHOPE) using the Liver Assist to preserve deceased donor livers for transplantation.

Начало: 01.01.2027 Край: 01.04.2033 Възраст: от 18 г.

XVIVO Perfusion NCT06916325

Предстои набиране Фаза 2

Daridorexant for Alcohol Use Disorder

Alcohol Use Disorder

This study will test whether the dual orexin receptor antagonist (DORA) daridorexant reduces alcohol craving and use and improves total sleep time among patients with co-occurring alcohol use disorder and sleep disturbance. The study will assess the role of the orexin system in modulating alcohol craving and use in a real-world treatment setting.

Начало: 01.01.2027 Край: 01.02.2031 Възраст: от 18 г.

Johns Hopkins University NCT07532252

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RCT on the Efficacy and Safety of Minimally Invasive SAIF Technique vs Spinal Fixation in Unstable Osteoporotic Vertebral Fractures

Unstable Osteoporotic Vertebral Compression Fractures

Osteoporotic vertebral fractures (OVF) represent a significant cause of morbidity, mortality, decreased level of function and quality of life. The most severe OVFs are unstable and in these cases surgical stabilization, with various techniques, is considered necessary to restore the physiological loading capacity of the spine, and allow fast and painless mobilization. Unfortunately, the elderly, osteoporotic patient population poses serious challenges to spinal surgery, due to tissue frailty and frequent comorbidities. The purpose of this study is to evaluate the effectiveness and safety of the SAIF intervention in comparison with multilevel surgical stabilization in participants with unstable OVFs.

Начало: 01.01.2027 Край: 31.12.2030 Възраст: от 50 г.

Switzerland Eva Koetsier MD PhD NCT07071870

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Therapeutic Ketogenic Diet in Partial Hospital Program (PHP) Anorexia Nervosa

Anorexia Nervosa

This will be a 14-week longitudinal study with an open design. A total of 120 individuals will be recruited for an end goal of 60 individuals with anorexia nervosa (AN) who are currently in high level of care treatment at the UCSD Eating Disorder Center partial hospital program (PHP) or intensive outpatient (IOP). Forty individuals will be recruited to the TKD and 20 will be treated with treatment as usual with respect to food intake. The age range will be between 16 and 45 years. All study participants will be carefully assessed and will complete rater and self-assessments at the being at the end of the study period. While in the treatment program, the TKD group will receive catered ketogenic meals via a meal service. After discharging from program, participants will have the option to continue with the meal service or cook for themselves. After establishing ketosis, study participants will continue TKD for 12 weeks. All study participants will be followed over three, six, and twelve months after enrolling in the study, whether initiating TKD or being in the treatment as usual arm. This follow-up procedure will help determine whether symptom improvement is stable or worsens in individuals who choose to continue or discontinue the TKD intervention and in relation to the control group. After ketosis induction over two weeks, study participants will be assessed weekly for ketosis and mood, anxiety, and eating disorder symptoms over twelve weeks.

Начало: 01.01.2027 Край: 31.08.2028 Възраст: 16–45 г.

United States University of California, San Diego NCT06605027

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Pulse Revolution: Enhancing Metabolic Health Through the Power of Processed Chickpeas

Healthy

The purpose of this research is to test how processing can affect how one's body uses the nutrients in that food. For this study the researchers are examining how making different food products out of chickpeas, such as hummus or pasta, changes how one's body uses those foods for energy.

Начало: 01.01.2027 Край: 01.12.2029 Възраст: 19–60 г.

United States USDA Grand Forks Human Nutrition Research Center NCT06758869

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Trial of Center-Based Early Start Denver Model vs. Pivotal Response Treatment in Children With Autism

Autism Spectrum Disorder (ASD) Autism

The goal of this study is to compare two well-established early autism interventions, Early Start Denver Model (ESDM) and Pivotal Response Treatment (PRT), to better understand which approach is most effective for improving communication skills in young children with autism and which children may benefit most from each treatment. Additionally, after completing either the ESDM or PRT, some participants who meet specific clinical criteria may be offered home-based Developmental Reciprocity Treatment (DRT). The study will include boys and girls 2 to 4 years 11 months old diagnosed with ASD. The main questions this study aims to answer are whether center-based ESDM and center-based PRT improve communication skills in young children with autism, and whether certain children respond better to one treatment approach than the other. Participants will be randomly assigned to either ESDM or PRT for 24 weeks in a center-based program, attend treatment session 4 days per week (\~3 hours/day), complete developmental and autism assessments at baseline, 12 weeks, and 24 weeks, have a parent participate in weekly parent training sessions, and complete follow-up assessments at weeks 36 and 48.

Начало: 01.01.2027 Край: 01.01.2037 Възраст: 2–4 г.

United States Stanford University NCT07522190

Предстои набиране Фаза 2

Umbilical Cord Mesenchymal Stem Cells Therapy (19#iSCLife®-SA) for Patients With Spinocerebellar Ataxia

Spinocerebellar Ataxia Type 1 Spinocerebellar Ataxia Type 2 Spinocerebellar Ataxia Type 3 Spinocerebellar Ataxia Type 6

The purpose of this study is verify the safety and efficacy of Human Umbilical Cord Mesenchymal Stem Cells (UC-MSC) therapy for patients with Spinocerebellar Ataxia, and in addition, explore the possible mechanisms of UC-MSC therapy in Spinocerebellar Ataxia.

Начало: 31.12.2026 Край: 31.12.2027 Възраст: 16–60 г.

Sclnow Biotechnology Co., Ltd. NCT03378414

Предстои набиране Фаза 1

Locoregional Administration of Genetically Engineered Cells (EGFR/IL13Rα2 Pool-CAR T Cells) for the Treatment of Recurrent or Progressive High-Grade Gliomas

Recurrent Astrocytoma, IDH-Mutant, Grade 4 Recurrent Glioblastoma, IDH-Wildtype

This phase I trial studies the side effects and best dose of EGFR/IL13Rα2 pool-chimeric antigen receptor (CAR) T cells when given through a thin, flexible tube into the brain (locoregional administration) in treating patients with high-grade gliomas that have come back after a period of improvement (recurrent) or that are growing, spreading, or getting worse (progressive). EGFR/IL13Rα2 pool-CAR T cells are a type of CAR T cell therapy. CAR T cell therapy is a type of treatment in which a patient's T cells (a type of immune system cell) are changed in the laboratory so they will attack tumor cells. T cells are taken from a patient's blood. Then the gene for a special receptor that binds to a certain protein on the patient's tumor cells is added to the T cells in the laboratory. The special receptor is called a CAR. Large numbers of the CAR T cells are grown in the laboratory and given to the patient by infusion for treatment of certain cancers.

Начало: 24.12.2026 Край: 12.02.2031 Възраст: от 18 г.

United States City of Hope Medical Center NCT07544992

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Neuraxial Ultrasound Device Study

Labor Pain Cesarean Delivery Regional Anesthesia Induction

The aim of the study is to develop a device that can eliminate failed neuraxial placements in challenging patients.The study will attempt to improve safety and efficacy of neuraxial anesthesia with high precision real-time needle visualization through automated real-time needle guidance at the bedside with an experimental device (Accuro 3S). Investigators will verify the clinical workflow for utilizing the Accuro 3S during epidural and spinal procedures and validation of needle visualization while using the device as well as anatomical guidance provided by the device during spinal imaging.The underlying bone imaging enhancement algorithms were introduced in the commercially available FDA approved Accuro. The Accuro 3S will be used to establish needle insertion point and trajectory, after which the clinician will use standard of care methods to advance the needle such as the loss of resistance method.

Начало: 15.12.2026 Край: 01.12.2027 Възраст: 18–65 г.

United States Stanford University NCT06281249

Предстои набиране Ранна Фаза 1

Mechanistic Clinical Trial of PCSK9 Inhibition for AAA

Abdominal Aortic Aneurysm

The goal of this mechanistic clinical trial is to assess whether lowering the low-density lipoprotein cholesterol (LDL-C) levels in the blood with the injections of the medication evolocumab will have any effect on the tissue or cells of patients with abdominal aortic aneurysm (AAA). Researchers will compare participants receiving evolocumab injections to participants receiving placebo injections to see how the tissue and cells of the aorta are affected by changes in LDL-C levels.

Начало: 01.12.2026 Край: 28.02.2029 Възраст: от 18 г.

United States University of Pennsylvania NCT06081153

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Individualized Energy Expenditure Assessment in Critically Ill Patients

Basal Metabolic Rate

General objective To assess the role of indirect calorimetry in measuring energy expenditure and assess guided nutritional support among critically ill patients in the ICU. Specific Objectives 1. To assess the nutritional status of critically ill patients admitted to the ICU. 2. To measure energy requirements of critically ill patients using indirect calorimetry. 3. To compare measured energy requirements obtained by indirect calorimetry with those estimated by predictive equations.

Начало: 01.12.2026 Край: 01.01.2028 Възраст: от 18 г.

Assiut University NCT07547865

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