Търсене на изпитвания

Активни:

Намерени 4,781 изпитвания Стр. 106 от 240

Набира участници Фаза 1/2

Study of Oral and Long-Acting Injectable Cabotegravir and Rilpivirine in Virologically Suppressed Children Living With HIV-1, Two to Less Than 12 Years of Age

HIV-1-infection

The purpose of the study is to evaluate the pharmacokinetics (PK), safety, tolerability, and acceptability of a long-acting injectable Cabotegravir and Rilpivirine in Virologically Suppressed Children Living with HIV-1, Two to Less Than 12 Years of Age

Начало: 24.01.2024 Край: 15.08.2027 Възраст: 2–11 г.

Botswana, Brazil, South Africa +2 National Institute of Allergy and Infectious Diseases ( NCT05660980

Набира участници Фаза 1/2

AZD3470 as Monotherapy or in Combination With Anticancer Agent(s) in Participants With Haematologic Malignancies.

Lymphoma Non-Hodgkin Lymphoma Hodgkin Lymphoma Peripheral T-cell Lymphoma (PTCL) +3

This study is designed to evaluate the safety, tolerability, PK, pharmacodynamics, and preliminary efficacy following oral administration of AZD3470 as a monotherapy, and in combination with other anticancer agents in participants with haematologic malignancies.

Начало: 23.01.2024 Край: 30.04.2029 Възраст: от 12 г. Лечение

Australia, China, France +7 AstraZeneca NCT06137144

Набира участници Фаза 4

THRomboprophylaxis in Individuals Undergoing Superficial endoVEnous Treatment (THRIVE)

Venous Thromboembolism Varicose Veins

Endovenous interventions are keyhole operations for varicose veins that are carried out from within the vein itself. Varicose veins are enlarged veins close to the surface of the skin. They are connected to the bigger deeper veins in the leg (known as deep veins). Because of this, operations to close the varicose veins can increase the chance of a blood clot forming in the deep veins. Blood clots in the deep veins happen in around 1 in 50 people after endovenous operations. A clot in the leg can cause swelling, pain, and other long-term problems. If a clot in the leg breaks off and travels to the lungs, it can cause problems with the lung' ability to move oxygen from the air into the blood and may, in rare cases, be life threatening. Varicose vein procedures may carry a slightly higher risk of blood clot formation, and we are currently unsure if current clot reducing medicines are beneficial in preventing blood clots in people having varicose vein procedures. This study will investigate if it is worthwhile prescribing medicines to reduce blood clots after varicose vein procedures.

Начало: 22.01.2024 Край: 31.12.2027 Възраст: от 18 г.

United Kingdom Imperial College London NCT05735639

Набира участници

Hyperbaric Oxygen Therapy for Men Suffering From Infertility Due to Oligospermia.

Oligospermia

Infertility in a couple is defined as the inability to achieve conception despite one year of frequent, unprotected intercourse. Infertility affects approximately 12% of couples attempting to conceive. The goal of this study is to explore the potential beneficial effect of HBOT on sperm count of infertile male due to oligospermia.

Начало: 20.01.2024 Край: 01.12.2030 Възраст: от 21 г.

Israel Assaf-Harofeh Medical Center NCT05842239

Набира участници Фаза 1

ATM-Inhibitor WSD0628 in Combination With Radiation Therapy for Treatment of Recurrent High-Grade Glioma

Glioblastoma

The purpose of this study is to test WSD0628 in combination with radiation therapy for recurrent brain tumors.

Начало: 17.01.2024 Край: 31.05.2029 Възраст: от 18 г.

United States Mayo Clinic NCT05917145

Набира участници Фаза 2

Evaluation of a Keto-Like Supplement on Brain Responses to Emotional Stimuli in Depression

Depression

This study aims to determine whether a keto-like supplement relative to placebo results in functional brain changes during fMRI tasks evaluating positive and negative valence in individuals with moderate to severe depression. In this double-blind randomized placebo-controlled trial, 75 individuals with a Patient Health Questionnaire (PHQ-9) scale score ≥ 10 (MDD) will be enrolled to participate in an 8-week treatment study to obtain 60 completers. Participants will be randomized with a 1-1 ratio to receive the keto-like supplement (n= 30 completers) or placebo (n=30 completers) taken orally three times per day for 8 weeks. Participants will undergo a 10.5-hour screening/baseline evaluation visit split over 2 days at week 0 including questionnaires, neuroimaging before and after supplement or placebo administration and blood draws, office visits at week 2 (1.5 hours), week 4 (3 hours), week 6 (0.5 hours), week 8 (6 hours), a follow-up visit at week 10 (1.5 hours) and two phone calls between visits (weeks 1 and 3) during which a brief clinical assessment will be obtained (10 minutes each). The total time involved in the study is approximately 23.5 hours.

Начало: 09.01.2024 Край: 01.12.2027 Възраст: 18–65 г.

United States Laureate Institute for Brain Research, Inc. NCT06263660

Набира участници

The Validation Study of Bioelectronics

Healthy Health Behavior

The purpose of this study is to investigate the safe wearability and basic functions of the multi-modality sensors fabricated in the PI lab.

Начало: 09.01.2024 Край: 01.11.2026 Възраст: 18–99 г.

United States University of North Carolina, Chapel Hill NCT05397951

Набира участници

A Translational Study to Describe Clinical Characteristics, Biomarkers and to Identify Phenotypes and Endotypes Associated With Differential Outcomes in Chinese Population

Asthma

A Translational Study to Describe Asthma Patient Clinical Characteristics, Treatment Patterns, Biomarkers and to Identify Phenotypes and Endotypes associated with Differential Outcomes that may Support Future Development of Personalised Treatment Strategies in Chinese Population

Начало: 08.01.2024 Край: 08.10.2026 Възраст: 18–75 г.

China AstraZeneca NCT06419413

Набира участници

Effect of Nicotinamide Riboside on Ketosis, Fat Oxidation & Metabolic Rate

Overweight Obesity

Background: At least 30% of Americans have fatty liver disease. This means that they store too much fat in the liver. At the moment lifestyle changes are the only way to treat this problem. Objective: To test how (1) a low-carbohydrate diet and (2) a supplement called nicotinamide riboside (NR) affect how a person s body uses dietary fat. Eligibility: Men aged 18 to 65 and women aged 18 to 50 who are healthy volunteers with a body mass index (height to weight ratio) of 25 or more. Adults with maturity-onset diabetes of the young type 2 (MODY2) are also needed. Design: Participants with diabetes will have 1 screening visit and a 9-day clinic stay. Healthy volunteers will have 1 screening visit and 2 clinic stays of 1 to 2 weeks each. During screening, all participants will have a physical exam with blood and urine tests. They will have their heart rhythm measured while riding a gym bike. NR is a pill taken by mouth. Only healthy volunteers will take the NR, for 14 days at a time, during 1 clinic stay. During their other stay, they will take placebos; these are pills that look like the study supplement but contain no NR. During each clinic stay, all participants will eat a normal American diet. Then they will eat a ketogenic "low-carb" diet for 5 days. Participants will have many tests, including: Sleeping every night and having two 24-hour stays in a special room that measures the gases their body uses and produces. Drinking a high-fat shake, then remaining seated for 5 hours while their blood and breath are monitored. Having a substance injected into the arm and remaining seated for 3 hours while their blood is measured. Wearing monitors to measure their activity levels. Another monitor will measure their blood glucose levels. Having imaging scans. ...

Начало: 08.01.2024 Край: 31.01.2028 Възраст: 18–65 г.

United States National Institute of Diabetes and Digestive and Kidney NCT06044935

Набира участници

Quantifying Bone and Skin Movement in the Residual Limb of Individuals With Transtibial Amputation Using Dynamic Stereo X-Ray

Amputation, Lower Limb

Individuals with lower extremity amputation are often challenged by complications that arise from poor prosthetic fit, including movement of the residual limb in the socket, known as pistoning. Pistoning can lead to gait instability, skin problems, and pain. Different prosthetic suspension systems have been developed to decrease this motion, including elevated vacuum suspension, which utilizes a pump to draw air from the socket. However, scientific analyses to understand the movement between the limb and socket have yet to be performed with a high level of accuracy. This study will use a state-of-the art imaging technique, known as dynamic stereo x-ray, to quantify the 3D movement of the residual limb in the socket. It is hypothesized that dynamic stereo x-ray will be a sensitive method to measure differences in residual limb movement between 2 different socket suspension techniques: suction and elevated vacuum suspension. This information is critical for advancing prosthetic treatments to reduce secondary conditions and degenerative changes that result from poor prosthetic fit.

Начало: 05.01.2024 Край: 31.03.2027 Възраст: от 18 г.

United States VA Office of Research and Development NCT05287646

Набира участници

BioBrace® Implant for Arthroscopic Repair of Full Thickness Rotator Cuff Tears

Rotator Cuff Tears

This study aims to evaluate the safety and effectiveness of arthroscopic rotator cuff repair augmented with the BioBrace® Implant vs. arthroscopic rotator cuff repair alone in subjects requiring surgical intervention for a full-thickness rotator cuff tear.

Начало: 05.01.2024 Край: 01.06.2027 Възраст: 40–70 г.

United States CONMED Corporation NCT05997381

Набира участници Фаза 1/2

PrProfile: A Study to Assess the Safety, Tolerability, Pharmacokinetics and Pharmacodynamics of ION717

Prion Disease

The purpose of this study is to evaluate the safety, tolerability, pharmacokinetics and pharmacodynamics of intrathecal (IT) delivery of ION717.

Начало: 04.01.2024 Край: 01.06.2030 Възраст: от 18 г. Лечение

Australia, Canada, France +6 Ionis Pharmaceuticals, Inc. NCT06153966

Набира участници Фаза 2

Testing the Anti-cancer Drug Erdafitinib for Brain Cancers That Have Returned or Progressed Following Treatment

Recurrent Glioma Recurrent WHO Grade 2 Glioma Recurrent WHO Grade 3 Glioma Recurrent WHO Grade 4 Glioma

This phase II trial tests how well erdafitinib works in controlling IDH-wild type (WT), FGFR-TACC gene fusion positive gliomas that have come back after a period of improvement (recurrent) or that are growing, spreading, or getting worse (progressive). Erdafitinib is in a class of medications called kinase inhibitors. It works by blocking the action of an abnormal FGFR protein that signals tumor cells to multiply. This may help keep tumor cells from growing and may kill them. Giving erdafitinib may help to slow the growth of, or to shrink, tumor cells in patients with recurrent or progressive IDH-wild type gliomas with FGFR-TACC gene fusion.

Начало: 04.01.2024 Край: 23.10.2026 Възраст: от 18 г.

United States National Cancer Institute (NCI) NCT05859334

Набира участници

Anxiety and Surgery Satisfaction for Cataract Patient With Different State Anxiety

Oral Anxiolytic Phacoemulsification Cataract Surgery Satisfaction Survey +1

This study aims to explore the effects of anxiety traits on pain, anxiety, and anesthesia satisfaction in patients undergoing cataract surgery under topical anesthesia. On the day of recruitment, patients will complete the BAI, STAI-S, and STAI-T anxiety questionnaires to assess baseline anxiety levels. Thirty minutes before the surgery, patients will be randomly assigned, in a double-blind manner, to receive either Xanax or a placebo and will retake the BAI, STAI-S, and STAI-T questionnaires. After the surgery, patients' pain levels and anesthesia satisfaction will be evaluated, with the pain scale and satisfaction survey repeated the following day. The results will analyze the relationship between anxiety traits and pharmacological interventions on the surgical experience, aiming to optimize surgical procedures and improve overall patient comfort.

Начало: 02.01.2024 Край: 31.12.2026 Възраст: 18–80 г.

Taiwan National Taiwan University Hospital NCT06826417

Набира участници

DINO RCT - Treating Anxiety in Children With Autism

Autism Spectrum Disorder Anxiety Disorders

Anxiety is prevalent in young children, under 7 years of age, with autism. Yet, few studies have examined anxiety interventions for this age range, and only one anxiety treatment study has included young children with cognitive and language delays. Anxiety treatment models utilizing cognitive-behavioral therapy (CBT), adapted for children with autism, are empirically supported in school-age autistic children. Further, preliminary evidence suggests CBT approaches may reduce intolerance of uncertainty (IU), a mechanistic construct that may contribute to the maintenance of anxiety in autistic children. This study seeks to address the existing gap in anxiety treatment by examining the feasibility and preliminary efficacy of a novel, telehealth CBT intervention, DINO Strategies for Anxiety and intolerance of Uncertainty Reduction (DINOSAUR), which targets both anxiety and IU in young autistic children.

Начало: 02.01.2024 Край: 15.10.2026 Възраст: 4–6 г.

United States Hugo W. Moser Research Institute at Kennedy Krieger, In NCT06066983

Набира участници

Clonal Hematopoiesis and Therapy-Emergent Myeloid Neoplasms in Patients With Cancers, CHANCES Study

Recurrent Fallopian Tube Carcinoma Recurrent Ovarian Carcinoma Recurrent Primary Peritoneal Carcinoma Recurrent Malignant Solid Neoplasm +6

This study is being done to investigate clonal hematopoiesis and therapy-emergent myeloid neoplasms in patients with ovarian or other solid cancers. Researchers want to identify risk factors for developing these blood cancers as well as if there is/are a genetic/environmental component(s) to developing blood cancer.

Начало: 02.01.2024 Край: 31.12.2031

United States University of Washington NCT06295965

Набира участници

Association Between Radial Artery Intervention and Development of Neuropathy in the Hand - A Prospective Study

Ischemic Heart Disease Nerve Injury Carpal Tunnel Syndrome

Evaluation of potential nerve damage after radial CAG/PCI.

Начало: 01.01.2024 Край: 01.12.2028 Възраст: от 18 г.

Denmark Aarhus University Hospital Skejby NCT05365282

Набира участници

Post-Debonding Finishing in Orthodontics

Caries Enamel Lesions

This study investigates clinical approaches to orthodontic debonding and post-debonding finishing, focusing on enamel preservation. An observational epidemiological survey was conducted among dental professionals to assess commonly used techniques, instruments, and complications. Results highlight variability in clinical protocols, with mechanical methods being the most widely adopted. The study emphasizes the importance of minimally invasive strategies to reduce enamel damage and improve patient outcomes.

Начало: 01.01.2024 Край: 01.06.2026

Italy University of Roma La Sapienza NCT07534423

Набира участници

Emergency Medicine Pulmonary Embolism Testing Multicentre Study

Pulmonary Embolism D-dimer Diagnosis

It is important to diagnose pulmonary embolism in a timely manner to prevent death and long-term disability. More than half a million people (4-5% of emergency department patients) are tested for pulmonary embolism, although the positive rate is low. Imaging for PE testing exposes patients to radiation, is expensive, adds time to the emergency visit, and can lead to a false positive diagnoses. Existing protocols aimed at reducing unnecessary pulmonary embolism imaging are complex and seldom used by emergency physicians. Too many patients undergo unnecessary pulmonary embolism imaging. A new tool (called Adjust-Unlikely) could safely reduce pulmonary embolism imaging in Canada. A research group composed of researchers, emergency physicians, and patients developed the Adjust-Unlikely clinical decision rule: a rule which has been customized for emergency physicians and emergency patients. Adjust-Unlikely is highly sensitive at the bedside, meaning there are very few false negative results. The study aim is to prospectively validate Adjust-Unlikely pulmonary embolism testing in emergency patients with suspected pulmonary embolism.

Начало: 01.01.2024 Край: 30.09.2027 Възраст: от 18 г.

Canada Dr. Kerstin de Wit NCT06320236

Набира участници Фаза 1/2

Bariatric Surgery Combined With GLP-1 Receptor Agonists Study

Obesity

Obese patients exhibit considerable heterogeneity and complex comorbidities, making long-term effective management challenging with single therapies. While bariatric surgery remains the most effective weight-loss intervention, postoperative weight regain and metabolic deterioration require attention. GLP-1 RAs offer distinct advantages for weight and metabolic improvement, and their combined application with surgery may yield synergistic benefits. This study investigates the efficacy and safety of bariatric surgery combined with GLP-1 receptor agonist adjuvant therapy for severe obesity.

Начало: 01.01.2024 Край: 01.12.2027 Възраст: 18–60 г.

China China-Japan Friendship Hospital NCT07336862

1 … 104 105 106 107 108 … 240