Comparative Study of Microneedling With Topical Minoxidil 5% ± NB-UVB in Stable Vitiligo"

This study is a randomized controlled trial comparing microneedling with topical minoxidil 5% versus microneedling with minoxidil combined with NB-UVB phototherapy in stable vitiligo. It aims to evaluate both clinical and histopathological outcomes in 30 patients with non-segmental stable vitiligo. Vitiligo is a chronic depigmenting disorder caused by melanocyte destruction with significant psychosocial impact. The study also investigates immunohistochemical changes, particularly Wnt/β-catenin signaling expression in lesional skin. The combination therapy is expected to enhance repigmentation by improving melanocyte activation, drug delivery, and angiogenesis

Inclusion Criteria: * Patients with stable non-segmental vitiligo (no new lesions, and no enlargement of existing lesions). Patients of both sexes Age 16 years or older Exclusion Criteria: Active vitiligo . Pregnant or lactating women. History of keloid formation. Hematological disorders coagulopathies, or use of anticoagulant therapy or medications that may prolong bleeding Previous vitiligo treatment in the last 2 months. \-