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Not yet recruiting Phase 1 NCT07539090

Evaluate the Effect of Vimseltinib on Pharmacokinetics of Combined Oral Contraceptive (Ethinyl Estradiol/Levonorgestrel)

Phase 1 – testing safety in a small group of people
Conditions: Healthy Participants

Sponsor: Deciphera Pharmaceuticals, LLC

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Overview
The main purpose of this study is to determine the effect of vimseltinib on pharmacokinetics of combined oral contraceptive (COC) (ethinyl estradiol/levonorgestrel) in healthy female participants. This study will last approximately 35 days.
Who can participate
Inclusion Criteria: 1. Participants are in good general health, as required by the protocol and as determined by Principal Investigator. 2. Body mass index (BMI) from greater than or equal to (≥) 18.5 to less than or equal to ≤ 30 kilogram per square meter (kg/m\^2). 3. Adequate organ function, blood and urine tests, as required by the protocol and as determined by Principal Investigator. Exclusion Criteria: 1. History or presence of clinically significant diseases of the neurological, dermatological, renal, hepatic, gastrointestinal, cardiovascular, or musculoskeletal systems or history or presence of clinically significant psychiatric, immunological, endocrine, or metabolic disease as determined by Principal Investigator. 2. Unwilling or unable to comply with the requirements of the protocol. 3. Determined by Principal Investigator to be unsuitable to participate in the study for any other reason.
Interventions
Vimseltinib
DRUG
Combined Oral Contraceptive (COC) (ethinyl estradiol [EE]/levonorgestrel [LNG])
DRUG
Locations

Location information is not available.

Technical details
Status
Not yet recruiting
Phase
Phase 1
Study type
INTERVENTIONAL
Sex
Female only
Minimum age
18 Years
Maximum age
55 Years
Healthy volunteers
No
Start date
01.05.2026
Completion date
01.06.2026
Registry ID
NCT07539090
Source
clinicaltrials.gov
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