This study will be a randomized, double-blinded, placebo-controlled study conducted at a university hospital. Forty children undergoing elective repair of a congenital heart defect will be included. The patients will be randomly allocated (20 patients per group) to receive a single intravenous dose of combined chlorpheniramine or normal saline immediately after separation from CPB, before protamine administration.
Who can participate
Inclusion Criteria:
* Acyanotic congenital heart disease.
* Age :1 -7 years.
* Genre: both.
Exclusion Criteria:
* Redo patient.
* History of allergy to antihistamines.
* Bleeding disorders with INR \> 1.5 and/or platelets \< 50,000.
* Emergency procedure.
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