Performance of the Treatment of Periodontitis According to the Bioperio® Protocol

This multicenter, prospective, single-arm observational study evaluated the clinical performance of the Bioperio® protocol, a standardized, patient-centered framework for managing periodontitis. The protocol combined professional supra-gingival scaling, oral hygiene instruction and motivation, full-mouth subgingival instrumentation, and-in Stage III/IV cases-adjunctive enamel matrix derivative application in deep pockets.

Inclusion Criteria: * Confirmed diagnosis of periodontitis (proximal attachment loss in ≥2 non-adjacent teeth) * No previous treatment for periodontitis * Systemically healthy or with well-controlled chronic medical conditions * Willingness to participate in the study and comply with the follow-up schedule Exclusion Criteria: * Pregnancy or breastfeeding * Patients previously treated for periodontitis * Poorly controlled systemic conditions * Refusal to participate * Patients who did not complete the proposed treatment plan