Comparative Efficacy of Antibiotics for Small Intestine Bacterial Overgrowth in Bangladeshi Children
Фаза 2 – изследване на ефективността и дозировката
Заболявания:
Small Intestine Bacterial Overgrowth
Спонсор: University of Virginia
Налично на:
БГ
Обобщение
The purpose of this Phase IIa study is to identify the most effective antibiotic regimen to treat small intestine bacterial overgrowth (SIBO) in impoverished Bangladeshi children.
Кой може да участва
Inclusion Criteria:
* Positive glucose hydrogen breath test (GHBT)
* Weight-for-age Z score \> -1
* Length-for-age Z score \> -1
Exclusion Criteria:
* Presence of known chronic or congenital illness, including developmental delay
* Presence of acute gastrointestinal illness in the preceding 14 days
* Antibiotic use in the preceding 14 days
* Previous adverse reaction to any of the three study medications or other drugs in the same antibiotic classes
* Sibling previously enrolled in this study
Интервенции
Trimethoprim-sulfamethoxazole (TMP/SMX)
DRUG
Metronidazole
DRUG
Amoxicillin-Clavulanate (4:1 formulation)
DRUG
Места на провеждане
1
Bangladesh (1)
International Centre for Diarrhoeal Disease Research, Bangladesh (icddr,b)