Efficacy and Safety of MET097 Once-Weekly in People With Overweight or Obesity
Phase 3 – large-scale trial before approval
Conditions:
Obesity and Overweight
Sponsor: Metsera, a wholly owned subsidiary of Pfizer
trial.available_in:
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Overview
This study investigates the efficacy and safety of once weekly injectable MET097 in adult participants with obesity or overweight with weight-related comorbidities excluding T2D. This trial will last for a duration of 84 weeks. The primary endpoint will be assessed after 64 weeks of treatment with the secondary at 84 weeks.
Who can participate
Inclusion Criteria:
* BMI ≥ 30 kg/m2 or BMI ≥ 27.0 kg/m2 to \<30.0 kg/m2 and presence of at least 1 of the following weight- related comorbidities: Hypertension, dyslipidemia, obstructive sleep apnea, or cardiovascular disease)
Exclusion Criteria:
* Have any form of diabetes
* Have a self-reported body weight change \> 5 kg (11 pounds) within 3 months prior to Screening
* Personal or family history of medullary thyroid carcinoma (MTC) or multiple endocrine neoplasia syndrome type 2 (MEN-2)
* History of chronic pancreatitis or presence of acute pancreatitis within the past 180 days prior to the Screening visit; or active/current, symptomatic gallbladder disease
Interventions
MET097
DRUG
Placebo
DRUG
Locations
196
Argentina (11)
CINME
Buenos Aires
NOT_YET_RECRUITING
CEDIC
Buenos Aires
NOT_YET_RECRUITING
Centro Medico Viamonte
Buenos Aires
NOT_YET_RECRUITING
Clinica Privada Velez Sarsfield
Córdoba
NOT_YET_RECRUITING
Instituto de Investigaciones Clinicas Cordoba
Córdoba
NOT_YET_RECRUITING
CIDIM
Córdoba
NOT_YET_RECRUITING
CIPADI - Centro Integral de Prevencion Y Atencion en Diabetes
Godoy Cruz
NOT_YET_RECRUITING
IIC Mar del Plata
Mar del Plata
NOT_YET_RECRUITING
CIAD Moron
Morón
NOT_YET_RECRUITING
Centro Medico Privado de Reumatologia
San Miguel de Tucumán
NOT_YET_RECRUITING
Instituto Medico Catamarca (IMEC)
Santa Fe
NOT_YET_RECRUITING
Bulgaria (16)
MHAT Botevgrad
Botevgrad
NOT_YET_RECRUITING
4 Life EOOD
Burgas
NOT_YET_RECRUITING
Multiprofile Hospital for Active Treatment Dobrich AD (MHAT Dobrich AD)
Dobrich
NOT_YET_RECRUITING
Medical Center New Polyclinic Gabrovo Ltd.
Gabrovo
NOT_YET_RECRUITING
Medical Center Zdrave 1
Kozloduy
NOT_YET_RECRUITING
FutureMeds Plovdiv
Plovdiv
NOT_YET_RECRUITING
MHAT Sveta Karidad EAD
Plovdiv
NOT_YET_RECRUITING
Diagnostic Consultative Center Aleksandrovska
Sofia
NOT_YET_RECRUITING
Medical Center Hera EOOD
Sofia
NOT_YET_RECRUITING
Prevencia - 2000 - Medical Center for Prehospital Medical Care OOD
Stara Zagora
NOT_YET_RECRUITING
UMHAT "Prof. Dr. Stoyan Kirkovich"AD
Stara Zagora
NOT_YET_RECRUITING
MC Nova Clinic
Varna
NOT_YET_RECRUITING
Medical Centre Pratia Clinic EOOD
Varna
NOT_YET_RECRUITING
Medical Center - Clinic Nova
Varna
NOT_YET_RECRUITING
MC Nevromedics Ltd.
Veliko Tarnovo
NOT_YET_RECRUITING
Medical Center Berbatov
Yambol
NOT_YET_RECRUITING
Canada (6)
C-health Research
Edmonton , Alberta
NOT_YET_RECRUITING
Centricity Research Etobicoke Endocrinology
Etobicoke , Ontario
NOT_YET_RECRUITING
The Wharton Medical Clinic Clinical Trials Inc
Hamilton , Ontario
NOT_YET_RECRUITING
Manna Research Mirabel
Mirabel , Quebec
NOT_YET_RECRUITING
Synergy Medical Clinic
Sherwood Park , Alberta
NOT_YET_RECRUITING
LMC Diabetes & Endocrinology - Bayview (Centricity Research Toronto LMC Multispecialty)
Toronto , Ontario
NOT_YET_RECRUITING
Czech Republic (10)
Pratia Brno,s.r.o
Brno
NOT_YET_RECRUITING
Nemocnice Jihlava
Jihlava
NOT_YET_RECRUITING
Edumed s.r.o.
Náchod
NOT_YET_RECRUITING
Agentura science pro s.r.o.
Olomouc
NOT_YET_RECRUITING
PreventaMed s.r.o.
Olomouc
NOT_YET_RECRUITING
CCR Ostrava
Ostrava
NOT_YET_RECRUITING
Pratia Pardubice
Pardubice
NOT_YET_RECRUITING
Fakultní nemocnice Královské Vinohrady
Prague
NOT_YET_RECRUITING
Synexus/Trialmed Prague
Prague
NOT_YET_RECRUITING
ResTrial s.r.o.
Prague
NOT_YET_RECRUITING
Germany (22)
Kardiologische Praxis Dr. med. univ. Wolfgang Jungmair
Bad Homburg
NOT_YET_RECRUITING
Klinische Forschung Berlin-Mitte GmbH
Berlin
NOT_YET_RECRUITING
FutureMeds Berlin
Berlin
NOT_YET_RECRUITING
Velocity Clinical Research Germany, Berlin
Berlin
NOT_YET_RECRUITING
Diabetespraxis Dr. Braun
Berlin
NOT_YET_RECRUITING
Pratia
Dresden
NOT_YET_RECRUITING
Medizentrum Essen Borbeck
Essen
NOT_YET_RECRUITING
Praxis am Markt - Dr. Bernd Becker
Essen
NOT_YET_RECRUITING
Klinische Forschung Hamburg GmbH / Pratia
Hamburg
NOT_YET_RECRUITING
Diabetes Studienzentrum Wilhelmsburg
Hamburg
NOT_YET_RECRUITING
DZHW
Hamburg
NOT_YET_RECRUITING
Praxis Reinfeld Mitte
Holstein
NOT_YET_RECRUITING
Zentrum fuer klinische Forschung Koeln Duennwald
Kaln
NOT_YET_RECRUITING
Klinische Forschung Karlsruhe GmbH
Karlsruhe
NOT_YET_RECRUITING
Studienzentrum FMZ Radowsky
Leipzig , Saxony
NOT_YET_RECRUITING
AmBeNet GmbH
Leipzig
NOT_YET_RECRUITING
CDG Studienambulanz Hartard
Munich , Bavaria
NOT_YET_RECRUITING
IDFM GmbH
Münster
NOT_YET_RECRUITING
Gemeinschaftspraxis PD Dr. med. habil. Holger Kittner & Dr. Hartig
Naunhof
NOT_YET_RECRUITING
FutureMeds Frankfurt/Offenbach
Offenbach
NOT_YET_RECRUITING
Zentrum für kliniche Studien Allgäu-Oberschwaben
Wangen
NOT_YET_RECRUITING
Medislim GmbH
Weinheim
NOT_YET_RECRUITING
Poland (33)
Zdrowie Osteo Medic sc L i A Racewicz, A i J Supronik
Bialystok
NOT_YET_RECRUITING
NZOZ Centrum Medyczne KERmed
Bydgoszcz
NOT_YET_RECRUITING
Centrum medyczne Pratia Bydgoszcz
Bydgoszcz
NOT_YET_RECRUITING
Pratia Chojnice
Chojnice
NOT_YET_RECRUITING
Synexus Polska Sp. z o.o., Oddzial w Czestochowie
Częstochowa
NOT_YET_RECRUITING
Synexus Polska Sp z o.o.
Gdansk
NOT_YET_RECRUITING
Centrum Badan Klinicznych PI-House Sp. z o.o.
Gdansk
NOT_YET_RECRUITING
Centrum Medyczne Pratia Gdynia
Gdynia
NOT_YET_RECRUITING
FutureMeds Gdynia
Gdynia
NOT_YET_RECRUITING
Synexus Polska Sp. z o.o. Oddzial w Gdyni
Gdynia
NOT_YET_RECRUITING
Synexus Polska Sp. Z O.O. Oddzial W Katowicach
Katowice
NOT_YET_RECRUITING
Centrum Medyczne Pratia Katowice
Katowice
NOT_YET_RECRUITING
FutureMeds Krakow
Krakow
NOT_YET_RECRUITING
Synexus Polska Sp. z o.o., Oddzial w Lodzi
Lodz
NOT_YET_RECRUITING
Santa Sp. z.o.o.
Lodz
NOT_YET_RECRUITING
Centrum Terapii Współczesnej J.M. Jasnorzewska Spółka Komandytowo-Akcyjna
Lodz
NOT_YET_RECRUITING
FutureMeds Lodz
Lodz
NOT_YET_RECRUITING
Ekamed Sp. z o. o.
Lublin
NOT_YET_RECRUITING
FutureMeds Olsztyn
Olsztyn
NOT_YET_RECRUITING
Medicome Sp. z o.o. Oświęcimskie Centrum Badań Klinicznych
Oświęcim
NOT_YET_RECRUITING
IRMED
Piotrkow Trybunalski
NOT_YET_RECRUITING
Trialmed CRS
Piotrkow Trybunalski
NOT_YET_RECRUITING
Synexus Polska Sp. z o.o., Oddział w Poznaniu
Poznan
NOT_YET_RECRUITING
Praktyka Lekarska Ewa Krzyzagorska
Poznan
NOT_YET_RECRUITING
ETG Siedlce
Siedlce
NOT_YET_RECRUITING
Metabolica Sp. z o.o., NZOZ METABOLICA Ośrodek Badań Klinicznych
Tarnów
NOT_YET_RECRUITING
FutureMeds Warszawa Centrum
Warsaw
NOT_YET_RECRUITING
Instytut Diabetologii.sp.z.o.o.
Warsaw
NOT_YET_RECRUITING
Synexus Polska Sp. z o.o., Oddzial w Warszawie
Warsaw
NOT_YET_RECRUITING
Etg Warszawa
Warsaw
NOT_YET_RECRUITING
FutureMeds Warszawa Targowek
Warszawa Targowek
NOT_YET_RECRUITING
Synexus Polska Sp. z o.o., Oddział we Wrocławiu
Wroclaw
NOT_YET_RECRUITING
FutureMeds Wroclaw
Wroclaw
NOT_YET_RECRUITING
Romania (11)
Minimed S.R.L.
Bacau
NOT_YET_RECRUITING
Futuremeds S.R.L., Brasov
Brasov
NOT_YET_RECRUITING
Hightech Medical Services S.R.L (Centrul pentru Studiul Metabolismului)
Bucharest
NOT_YET_RECRUITING
Fundatia Dr Victor Babes
Bucharest
NOT_YET_RECRUITING
Institutul Clinic Fundeni
Bucharest
NOT_YET_RECRUITING
Institutul National de Endocrinologie "C.I. Parhon"
Bucharest
NOT_YET_RECRUITING
Futuremeds S.R.L., Craiova
Craiova
NOT_YET_RECRUITING
Futuremeds S.R.L., Galati
Galati
NOT_YET_RECRUITING
Centru Medical "GRANDMED"
Oradea
NOT_YET_RECRUITING
Sc Gensan Srl/Policlinica Astra
Sibiu
NOT_YET_RECRUITING
Centrul Medical Mediab - Mediab Srl
Târgu Mureş
NOT_YET_RECRUITING
Slovakia (9)
Medispektrum
Bratislava
NOT_YET_RECRUITING
DIABEDA s.r.o.
Bratislava
NOT_YET_RECRUITING
Poliklinika Váš Lekár
Bratislava - Ružinov
NOT_YET_RECRUITING
Cardio D&R Košice
Košice
NOT_YET_RECRUITING
Medical group Kosice s.r.o.
Košice
NOT_YET_RECRUITING
MEDI-DIA s.r.o.
Prešov
NOT_YET_RECRUITING
Tatratrial s.r.o.
Rožňava
NOT_YET_RECRUITING
JAL s.r.o.
Trnava
NOT_YET_RECRUITING
Medivasa sro
Žilina
NOT_YET_RECRUITING
Spain (11)
Hospital Universitario Torrecárdenas (CPE Bola Azul)
Almería
NOT_YET_RECRUITING
Hospital Universitari Vall d'Hebron
Barcelona
NOT_YET_RECRUITING
Hospital Vithas Sevilla
Castilleja de la Cuesta
NOT_YET_RECRUITING
Futuremeds Spain Cadiz
Chiclana de la Frontera
NOT_YET_RECRUITING
Futuremeds Spain Madrid
Madrid
NOT_YET_RECRUITING
Hospital Universitario Virgen de la Victoria
Málaga , Málaga
NOT_YET_RECRUITING
Hospital Universitari Son Espases
Palma de Mallorca
NOT_YET_RECRUITING
Hospital Virgen del Camino
Sanlúcar de Barrameda
NOT_YET_RECRUITING
Nuevas Tecnologías en Diabetes y Endocrinología S.L.
Seville
NOT_YET_RECRUITING
Futuremeds Spain Sevilla
Seville
NOT_YET_RECRUITING
Ecg Médica S.L.
Valencia
NOT_YET_RECRUITING
United Kingdom (32)
Synexus/Trialmed Glasgow
Bellshill
NOT_YET_RECRUITING
Synexus/Trialmed Midlands
Birmingham
NOT_YET_RECRUITING
FutureMeds (Birmingham)
Birmingham
NOT_YET_RECRUITING
Boots Birmingham
Birmingham
NOT_YET_RECRUITING
Boots Brighton
Brighton , EAST Sussex
NOT_YET_RECRUITING
Southmead Hospital
Bristol
NOT_YET_RECRUITING
FutureMeds Liverpool
Bromborough
NOT_YET_RECRUITING
Synexus/Trialmed Cardiff
Cardiff
NOT_YET_RECRUITING
Panthera Biopartners Limited - Enfield
Enfield
NOT_YET_RECRUITING
FutureMeds Glasgow McCafferty House
Glasgow , Scotland
NOT_YET_RECRUITING
Panthera Biopartners Limited - Glasgow
Glasgow
NOT_YET_RECRUITING
Civia Health Sunderland
Hendon , CITY of Sunderland
NOT_YET_RECRUITING
Bodyline Medical Clinic Crosby
Liverpool
NOT_YET_RECRUITING
FutureMeds London
London
NOT_YET_RECRUITING
Synexus/Trialmed Manchester
Manchester
NOT_YET_RECRUITING
Kiltearn Medical Centre
Nantwich
NOT_YET_RECRUITING
FutureMeds Newcastle
Newcastle upon Tyne
NOT_YET_RECRUITING
DANES Medical Centre
Northampton
NOT_YET_RECRUITING
Boots Nottingham
Nottingham , Nottinghamshire
NOT_YET_RECRUITING
Bodyline Medical Research Openshaw
Openshaw , Manchester
NOT_YET_RECRUITING
Boots Peterborough
Peterborough , Cambridgeshire
NOT_YET_RECRUITING
Panthera Biopartners Limited - Preston
Preston
NOT_YET_RECRUITING
Panthera Biopartners Limited - Rochdale
Rochdale
NOT_YET_RECRUITING
Clifton Medical Centre
Rotherham
NOT_YET_RECRUITING
Sandbach GPs
Sandbach
NOT_YET_RECRUITING
Panthera Biopartners Limited - Sheffield
Sheffield
NOT_YET_RECRUITING
Staploe Medical Centre
Soham
NOT_YET_RECRUITING
Bodyline Medical Clinic St Helens
St Helens , Liverpool
NOT_YET_RECRUITING
Bodyline Medical Clinic Stoke on Trent
Stoke-on-Trent
NOT_YET_RECRUITING
Futuremeds Teesside Middlefield Centre University Hospital of North Tees
Teeside
NOT_YET_RECRUITING
Bodyline Medical Clinic Warrington
Warrington , Cheshire EAST
NOT_YET_RECRUITING
Panthera Biopartners Limited - York
York
NOT_YET_RECRUITING
United States (35)
DelRicht Research @ Springer Wellness and Restorative Health
Atlanta , Georgia
Forum Austin (Civia Health)
Austin , Texas
Pantheon Clinical Research
Bountiful , Utah
Alliance Research Institute
Canoga Park , California
Forum Health Cary
Cary , North Carolina
Clinical Research Professionals
Chesterfield , Missouri
Civia Health St. Louis
Creve Coeur , Missouri
NOT_YET_RECRUITING
Cedar Health Research
Dallas , Texas
NOT_YET_RECRUITING
Eximia EquiHealth Research
Durham , North Carolina
GLRI El Paso Research
El Paso , Texas
CenExcel Rocky Mountain Clinical Research, LLC
Englewood , Colorado
CenExel CBH Health
Gaithersburg , Maryland
Civia Health Goodlettsville
Goodlettsville , Tennessee
Tribe Clinical Research, LLC
Greenville , South Carolina
Research Centers of America
Hollywood , Florida
Civia Health Independence
Independence , Missouri
NOT_YET_RECRUITING
Civia Health Nashville
La Vergne , Tennessee
Future Medical Research (Civia Health)
Longwood , Florida
CenExel HRI - Hassman Research Institute
Marlton , New Jersey
Civia Health Memphis
Memphis , Tennessee
NOT_YET_RECRUITING
Advanced Clinical Research
Miami , Florida
Quality Clinical Research Inc
Omaha , Nebraska
Oviedo Medical Research
Oviedo , Florida
Primary Care Research (Civia Health)
Papillion , Nebraska
Summit Headlands LLC
Portland , Oregon
Dallas Clinical Research Center (Pillar Clinical Research)
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