Evaluation of Efficacy, Safety, and Tolerability of Povetacicept in Participants With Primary Membranous Nephropathy (pMN)
Phase 2/3 – combined trial
Conditions:
Primary Membranous Nephropathy
Sponsor: Vertex Pharmaceuticals Incorporated
trial.available_in:
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Overview
The purpose of this study is to evaluate the efficacy, safety, and tolerability of povetacicept in participants with primary membranous nephropathy (pMN).
Who can participate
Key Inclusion Criteria:
• Diagnosed with pMN with confirmatory historical biopsy. If no historical biopsy was performed that confirmed pMN, a biopsy can be performed during Screening to confirm eligibility
Key Exclusion Criteria:
• Hypersensitivity to investigational medicinal product or to any of its excipients
Other protocol defined Inclusion/Exclusion criteria will apply
Interventions
Povetacicept
DRUG
Tacrolimus
DRUG
Locations
86
Australia (2)
St George Private Hospital
Kogarah
University of Newcastle - John Hunter Hospital (JHH)
New Lambton Heights
Brazil (3)
Santa Casa de Misericordia
Porto Alegre
Fundação Bahiana de Infectologia
Salvador
Hospital das Clinicas da Faculdade de Medicina da USP - HC- FMUSP
São Paulo
China (30)
The First Affiliated Hospital of Baotou Medical College
Baotou
Beijing Tsinghua Changgung Hospital
Beijing
Peking University First Hospital
Beijing
The First Affiliated Hospital of Bengbu Medical University
Bengbu
The Second Norman Bethune Hospital of Jilin University
Changchun
Xiangya Hospital of Central South University
Changsha
Sichuan Academy of Medical Sciences ＆ Sichuan Provincial People's Hospital
Chengdu
Dalian Municipal Central Hospital
Dalian
Dongguan People's Hospital
Dongguan
Fuyang People's Hospital
Fuyang
Guangdong Provincial People's Hospital
Guangzhou
The First Affiliated Hospital,Sun Yat-sen University
Guangzhou
The Affiliated Huai'an No.1 People's Hospital of Nanjing Medical University
Huai'an
The Second Qilu Hospital of Shandong University
Jinan
Liu Zhou Works Hospital
Liuchow
The First Affiliated Hospital of Nanchang University
Nanchang
The People's Hospital of Guangxi Zhuang Autonomous Region
Nanning
Nanyang Central Hospital
Nanyang
The First Affiliated Hospital of Ningbo University
Ningbo
Renji Hospital Shanghai Jiaotong University School of Medicine
Shanghai
Shanghai General Hospital
Shanghai
The First Hospital of Hebei Medical University
Shijiazhuang
The Second Hospital of Hebei Medical University
Shijiazhuang
Tai'an City Central Hosptial
Tai’an
Weifang People's Hospital
Weifang
Wuxi People's Hospital
Wuxi
The First Affiliated Hospital of Xi 'an Jiaotong University
Xi'an
The First Affiliated Hospital of Xiamen University
Xiamen
Yantai YuHuangDing Hospital
Yantai
Yichang Central People Hospital
Yichang
Czech Republic (1)
Vseobecna fakultni nemocnice v Praze - Klinika nefrologie
Prague
Germany (4)
Charite - Universitaetsmedizin Berlin Campus Benjamin Frankl
Allemagne
Klinikum St. Georg gGmbH - Nephrology
Leipzig
Universitaetsklinikum Leipzig - Medizinische Klinik und Poliklinik III - Klinik und Poliklinik fuer Endokrinologie, Nephrologie
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