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Recruiting Phase 2 NCT06830629

A Phase 2 Study of MZE829 in Adults With APOL1 Kidney Disease

Phase 2 – studying effectiveness and dosage
Conditions: Proteinuric Kidney Disease

Sponsor: Maze Therapeutics

trial.available_in: БГ
Overview
This is purpose of this study is to evaluate the safety, tolerability, and effect on Albuminuria of MZE829 in Adults with APOL1 Kidney Disease
Description
An open-label Phase 2 study is designed to evaluate the safety, tolerability, and effect on Albuminuria of MZE829 in Adults with Proteinuric Chronic Kidney Disease and the APOL1 High Risk Genotype.
Who can participate
Key Inclusion Criteria: * APOL1 high risk genotype of G1/G1, G2/G2, or G1/G2 * Chronic kidney disease with persistent albuminuria Key Exclusion Criteria: * Organ or bone marrow transplantation * History of cancer within past 2 years, excepted for treated non-melanoma skin cancer, stage 0 cervical cancer, or stage 1 prostate cancer * Conditions that may alter drug absorption, e.g., history of bariatric surgery * Type I diabetes * Pregnant or currently nursing Other inclusion/exclusion criteria defined in protocol apply.
Interventions
MZE829
DRUG
Locations 81
France (5)
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Créteil
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Lyon
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Paris
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Paris
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Saint-Ouen
United Kingdom (4)
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Leicester
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London
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London
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London
United States (72)
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Ardmore , Oklahoma
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Arnold , Maryland
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Atlanta , Georgia
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Atlantis , Florida
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Bloomfield , Connecticut
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Bowling Green , Kentucky
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Brandon , Florida
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Brooksville , Florida
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Buffalo , New York
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Chattanooga , Tennessee
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Chicago , Illinois
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Chicago , Illinois
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Cincinnati , Ohio
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City of Saint Peters , Missouri
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Cleveland , Ohio
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Cleveland , Ohio
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College Park , Georgia
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Columbia , South Carolina
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Columbus , Ohio
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Cordele , Georgia
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Dallas , Texas
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Dallas , Texas
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Dearborn , Michigan
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Decatur , Alabama
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Durham , North Carolina
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Fayetteville , North Carolina
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Flint , Michigan
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Granada Hills , California
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Greensboro , North Carolina
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Greenville , Texas
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Hollywood , Florida
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Houston , Texas
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Houston , Texas
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Houston , Texas
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Huntsville , Alabama
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Kansas City , Kansas
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Las Vegas , Nevada
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Laurelton , New York
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Lithia Springs , Georgia
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Louisville , Kentucky
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Lutherville , Maryland
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Macon , Georgia
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Maspeth , New York
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McKinney , Texas
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Melbourne , Florida
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Miami Lakes , Florida
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Minneapolis , Minnesota
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Montgomery , Alabama
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Montgomery , Alabama
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New York , New York
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Newburgh , New York
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Norfolk , Virginia
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Orlando , Florida
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Oxon Hill , Maryland
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Philadelphia , Pennsylvania
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Philadelphia , Pennsylvania
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Pontiac , Michigan
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Riverdale , Georgia
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Riverdale , Georgia
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Saint Joseph , Michigan
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San Antonio , Texas
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Savannah , Georgia
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Shelby , Michigan
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Shelby , North Carolina
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Shenandoah , Texas
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Sherman , Texas
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Snellville , Georgia
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Spartanburg , South Carolina
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Spartanburg , South Carolina
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St Louis , Missouri
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Tupelo , Mississippi
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Upland , Pennsylvania
Technical details
Status
Recruiting
Phase
Phase 2
Study type
INTERVENTIONAL
Sex
Male and female
Minimum age
18 Years
Maximum age
68 Years
Healthy volunteers
No
Start date
05.02.2025
Completion date
01.09.2026
Registry ID
NCT06830629
Source
clinicaltrials.gov
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