HNC: Human Neural Circuits Electrophysiology During Cognition

The purpose of this study is to understand how ketamine brings about dissociative symptoms.

The goal of this proposed research is to record the effects of ketamine on brain activity to understand the changes that occur during antidepressant therapy and the side effect of dissociation. This research is designed to probe altered cognitive states associated with dissociation, depression, and other neuropsychiatric conditions.

Inclusion Criteria: * Patient in clinical neuro inpatient units at Stanford Medical Center * Age \>18 years old * Female participants are expected to use an effective method of birth control throughout the study which includes: hormonal methods (birth control pills, patches, injections, vaginal ring or implants), barrier methods (condom or diaphragm) used with spermicide, intrauterine device (IUD), or abstinence (no sex) Exclusion Criteria: * Lifetime psychotic disorder * Pregnant or nursing females * Prior adverse ketamine response * Use of ketamine in past 7 days