Ramucirumab Plus Pembrolizumab vs Usual Care for Treatment of Stage IV or Recurrent Non-Small Cell Lung Cancer Following Immunotherapy, Pragmatica-Lung Study
Phase 3 – large-scale trial before approval
Conditions:
Recurrent Lung Non-Small Cell Carcinoma
Stage IV Lung Cancer AJCC v8
Sponsor: SWOG Cancer Research Network
trial.available_in:
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Overview
This phase III trial compares the effect of the combination of ramucirumab and pembrolizumab versus standard of care chemotherapy for the treatment of non-small cell lung cancer that is stage IV or that has come back after a period of improvement (recurrent). Ramucirumab is a monoclonal antibody that may prevent the growth of new blood vessels that tumors need to grow. Immunotherapy with monoclonal antibodies, such as pembrolizumab, may help the body's immune system attack the cancer, and may interfere with the ability of tumor cells to grow and spread. Chemotherapy drugs work in different ways to stop the growth of tumor cells, either by killing the cells, by stopping them from dividing, or by stopping them from spreading. This trial may help doctors find out if giving ramucirumab with pembrolizumab is more effective at treating patients with stage IV or recurrent non-small cell lung cancer than standard chemotherapy.
Description
PRIMARY OBJECTIVE:
I. To compare overall survival (OS) in participants previously treated with platinum-based chemotherapy and immunotherapy for stage IV or recurrent non-small cell lung cancer (NSCLC) randomized to pembrolizumab and ramucirumab versus standard of care.
SECONDARY OBJECTIVE:
I. To summarize reports of serious and unexpected high-grade (\>= grade 3) treatment-related adverse events determined by the treating physician within each treatment arm.
OUTLINE: Patients are randomized to 1 of 2 arms.
ARM A: Patients receive chemotherapy per standard of care on study.
ARM B: Patients receive ramucirumab intravenously (IV) and pembrolizumab IV on study.
Who can participate
Inclusion Criteria:
* Participants must have histologically or cytologically confirmed non-small cell lung cancer (NSCLC) which is stage IV or recurrent
* Participants must have received at least one line of anti-PD-1 or anti-PD-L1 therapy for any stage of NSCLC. Anti-PD-1 or anti-PD-L1 may have been given alone or in combination with other therapy
* Participants must have experienced disease progression (in the opinion of the treating physician) more than (\>) 84 days following initiation (cycle 1 day 1) of their most recent anti-PD-1 or PD-L1 therapy
* Participants who received anti-PD-1 or anti-PD-L1 therapy for stage IV or recurrent disease, must have had a best response on anti-PD-1 or anti-PD-L1 therapy of stable, partial response or complete response (in the opinion of the treating physician)
* Participants who received neoadjuvant, adjuvant, and/or consolidation anti-PD-1 or anti-PD-L1 therapy as their only line of anti-PD-1 or anti-PD-L1 therapy must have experienced disease progression within (=\<) 365 days from initiation (cycle 1 day 1) of anti-PD-1 or PD-L1 therapy
* Participants must have received platinum-based chemotherapy and experienced disease progression (in the opinion of the treating physician) during or after this regimen
* Participants with a known sensitizing mutation for which an Food and Drug Administration (FDA)-approved targeted therapy for NSCLC exists (e.g., EGFR, ALK, ROS1, BRAF, RET, NTRK, KRAS, HER2 and MET sensitizing mutations), must have previously received at least one of the approved therapy(s). Prior targeted therapy for participants with targetable alterations is allowed if all other eligibility criteria are also met
* Participants must be \>= 18 years old
* Participants must be able to safely receive the investigational drug combination and the investigator's choice of standard of care regimens per the current FDA approved package insert(s), treating investigator's discretion, and institutional guidelines
* Participants must have Zubrod performance status of 0-2
Exclusion Criteria:
* Participants must not have received more than one line of anti-PD-1 or anti-PD-L1 for stage IV or recurrent disease
* Participants must not be receiving or planning to receive another investigational therapy during study participation
Interventions
Chemotherapy
DRUG
Pembrolizumab
BIOLOGICAL
Ramucirumab
BIOLOGICAL
Locations
566
United States (566)
Hawaii Cancer Care - Westridge
‘Aiea , Hawaii
Pali Momi Medical Center
‘Aiea , Hawaii
Summa Health System - Akron Campus
Akron , Ohio
Cleveland Clinic Akron General
Akron , Ohio
Atrium Health Stanly/LCI-Albemarle
Albemarle , North Carolina
University of New Mexico Cancer Center
Albuquerque , New Mexico
Lehigh Valley Hospital-Cedar Crest
Allentown , Pennsylvania
UPMC Altoona
Altoona , Pennsylvania
The Don and Sybil Harrington Cancer Center
Amarillo , Texas
Community Hospital of Anaconda
Anaconda , Montana
Kaiser Permanente-Anaheim
Anaheim , California
AnMed Health Cancer Center
Anderson , South Carolina
Saint Joseph Mercy Hospital
Ann Arbor , Michigan
University of Michigan Comprehensive Cancer Center
Ann Arbor , Michigan
Langlade Hospital and Cancer Center
Antigo , Wisconsin
ThedaCare Regional Cancer Center
Appleton , Wisconsin
PCR Oncology
Arroyo Grande , California
AdventHealth Infusion Center Asheville
Asheville , North Carolina
King's Daughter's Medical Center
Ashland , Kentucky
Northside Hospital
Atlanta , Georgia
Sutter Auburn Faith Hospital
Auburn , California
Rocky Mountain Regional VA Medical Center
Aurora , Colorado
UCHealth University of Colorado Hospital
Aurora , Colorado
Rush - Copley Medical Center
Aurora , Illinois
UM Sylvester Comprehensive Cancer Center at Aventura
Aventura , Florida
Kaiser Permanente-Baldwin Park
Baldwin Park , California
Greater Baltimore Medical Center
Baltimore , Maryland
Sinai Hospital of Baltimore
Baltimore , Maryland
Kaiser Permanente-Woodlawn Medical Center
Baltimore , Maryland
Summa Health System - Barberton Campus
Barberton , Ohio
Advocate Good Shepherd Hospital
Barrington , Illinois
Louisiana Hematology Oncology Associates LLC
Baton Rouge , Louisiana
Mary Bird Perkins Cancer Center
Baton Rouge , Louisiana
Bronson Battle Creek
Battle Creek , Michigan
Houston Methodist San Jacinto Hospital
Baytown , Texas
UPMC-Heritage Valley Health System Beaver
Beaver , Pennsylvania
Kaiser Permanente-Bellflower
Bellflower , California
PeaceHealth Saint Joseph Medical Center
Bellingham , Washington
Strecker Cancer Center-Belpre
Belpre , Ohio
Sanford Joe Lueken Cancer Center
Bemidji , Minnesota
Alta Bates Summit Medical Center-Herrick Campus
Berkeley , California
Walter Reed National Military Medical Center
Bethesda , Maryland
Lehigh Valley Hospital - Muhlenberg
Bethlehem , Pennsylvania
University of Iowa Healthcare Cancer Services Quad Cities
Bettendorf , Iowa
Beverly Hospital
Beverly , Massachusetts
Tower Cancer Research Foundation
Beverly Hills , California
Billings Clinic Cancer Center
Billings , Montana
University of Alabama at Birmingham Cancer Center
Birmingham , Alabama
Sanford Bismarck Medical Center
Bismarck , North Dakota
Illinois CancerCare-Bloomington
Bloomington , Illinois
Saint Joseph's/Candler - Bluffton Campus
Bluffton , South Carolina
Saint Alphonsus Cancer Care Center-Boise
Boise , Idaho
Saint Luke's Cancer Institute - Boise
Boise , Idaho
Boston Medical Center
Boston , Massachusetts
Bozeman Deaconess Hospital
Bozeman , Montana
Saint Joseph Mercy Brighton
Brighton , Michigan
Trinity Health IHA Medical Group Hematology Oncology - Brighton
Brighton , Michigan
Bryn Mawr Hospital
Bryn Mawr , Pennsylvania
Lahey Hospital and Medical Center
Burlington , Massachusetts
Aurora Cancer Care-Southern Lakes VLCC
Burlington , Wisconsin
UPMC Hillman Cancer Center at Butler Health System
Butler , Pennsylvania
Saint Alphonsus Cancer Care Center-Caldwell
Caldwell , Idaho
Cooper Hospital University Medical Center
Camden , New Jersey
Marshall Cancer Center
Cameron Park , California
UPMC Camp Hill
Camp Hill , Pennsylvania
Cleveland Clinic Mercy Hospital
Canton , Ohio
Aultman Health Foundation
Canton , Ohio
Illinois CancerCare-Canton
Canton , Illinois
Saint Joseph Mercy Canton
Canton , Michigan
Trinity Health IHA Medical Group Hematology Oncology - Canton
Canton , Michigan
Saint Francis Medical Center
Cape Girardeau , Missouri
Carlisle Regional Cancer Center
Carlisle , Pennsylvania
Illinois CancerCare-Carthage
Carthage , Illinois
Rex Hematology Oncology Associates-Cary
Cary , North Carolina
Mercy Hospital
Cedar Rapids , Iowa
Oncology Associates at Mercy Medical Center
Cedar Rapids , Iowa
Miami Valley Hospital South
Centerville , Ohio
WellSpan Medical Oncology and Hematology
Chambersburg , Pennsylvania
UNC Lineberger Comprehensive Cancer Center
Chapel Hill , North Carolina
Medical University of South Carolina
Charleston , South Carolina
West Virginia University Charleston Division
Charleston , West Virginia
Carolinas Medical Center/Levine Cancer Institute
Charlotte , North Carolina
Atrium Health Pineville/LCI-Pineville
Charlotte , North Carolina
Levine Cancer Institute-SouthPark
Charlotte , North Carolina
Atrium Health University City/LCI-University
Charlotte , North Carolina
Levine Cancer Institute-Ballantyne
Charlotte , North Carolina
University of Virginia Cancer Center
Charlottesville , Virginia
Saint Joseph Mercy Chelsea
Chelsea , Michigan
Trinity Health IHA Medical Group Hematology Oncology - Chelsea Hospital
Chelsea , Michigan
Northwestern University
Chicago , Illinois
University of Illinois
Chicago , Illinois
Swedish Covenant Hospital
Chicago , Illinois
Advocate Illinois Masonic Medical Center
Chicago , Illinois
Adena Regional Medical Center
Chillicothe , Ohio
Siteman Cancer Center at Saint Peters Hospital
City of Saint Peters , Missouri
Cleveland Clinic Cancer Center/Fairview Hospital
Cleveland , Ohio
Cleveland Clinic Foundation
Cleveland , Ohio
Southeastern Medical Oncology Center-Clinton
Clinton , North Carolina
AdventHealth Infusion Center Haywood
Clyde , North Carolina
Kootenai Health - Coeur d'Alene
Coeur d'Alene , Idaho
Baptist Memorial Hospital and Cancer Center-Collierville
Collierville , Tennessee
UCHealth Memorial Hospital Central
Colorado Springs , Colorado
Memorial Hospital North
Colorado Springs , Colorado
Mount Carmel East Hospital
Columbus , Ohio
The Mark H Zangmeister Center
Columbus , Ohio
Baptist Memorial Hospital and Cancer Center-Golden Triangle
Columbus , Mississippi
Atrium Health Cabarrus/LCI-Concord
Concord , North Carolina
Mercy Hospital
Coon Rapids , Minnesota
UM Sylvester Comprehensive Cancer Center at Coral Gables
Coral Gables , Florida
Siteman Cancer Center at West County Hospital
Creve Coeur , Missouri
Northwest Cancer Center - Main Campus
Crown Point , Indiana
AMG Crystal Lake - Oncology
Crystal Lake , Illinois
UPMC Western Maryland
Cumberland , Maryland
Dallas VA Medical Center
Dallas , Texas
Carle at The Riverfront
Danville , Illinois
Geisinger Medical Center
Danville , Pennsylvania
Dayton Blood and Cancer Center
Dayton , Ohio
Miami Valley Hospital
Dayton , Ohio
Dayton Physician LLC-Miami Valley Hospital North
Dayton , Ohio
Miami Valley Hospital North
Dayton , Ohio
Cancer Care Specialists of Illinois - Decatur
Decatur , Illinois
Decatur Memorial Hospital
Decatur , Illinois
UM Sylvester Comprehensive Cancer Center at Deerfield Beach
Deerfield Beach , Florida
Northwestern Medicine Cancer Center Kishwaukee
DeKalb , Illinois
Kaiser Permanente-Franklin
Denver , Colorado
Smilow Cancer Hospital-Derby Care Center
Derby , Connecticut
Medical Oncology and Hematology Associates-Des Moines
Des Moines , Iowa
Mercy Medical Center - Des Moines
Des Moines , Iowa
Ascension Saint John Hospital
Detroit , Michigan
Illinois CancerCare-Dixon
Dixon , Illinois
Advocate Good Samaritan Hospital
Downers Grove , Illinois
City of Hope Comprehensive Cancer Center
Duarte , California
Kaiser Permanente Dublin
Dublin , California
Northside Hospital - Duluth
Duluth , Georgia
Duke University Medical Center
Durham , North Carolina
Northwest Oncology LLC
Dyer , Indiana
Great Lakes Cancer Management Specialists-Doctors Park
East China , Michigan
Pocono Medical Center
East Stroudsburg , Pennsylvania
HSHS Sacred Heart Hospital
Eau Claire , Wisconsin
Fairview Southdale Hospital
Edina , Minnesota
Carle Physician Group-Effingham
Effingham , Illinois
Crossroads Cancer Center
Effingham , Illinois
Advocate Sherman Hospital
Elgin , Illinois
Trinitas Hospital and Comprehensive Cancer Center - Williamson Street Campus
Elizabeth , New Jersey
Arnot Ogden Medical Center/Falck Cancer Center
Elmira , New York
Ephrata Cancer Center
Ephrata , Pennsylvania
UPMC Hillman Cancer Center Erie
Erie , Pennsylvania
Green Bay Oncology - Escanaba
Escanaba , Michigan
Illinois CancerCare-Eureka
Eureka , Illinois
NorthShore University HealthSystem-Evanston Hospital
Evanston , Illinois
Smilow Cancer Hospital Care Center-Fairfield
Fairfield , Connecticut
Sanford Broadway Medical Center
Fargo , North Dakota
Sanford Roger Maris Cancer Center
Fargo , North Dakota
Parkland Health Center - Farmington
Farmington , Missouri
UPMC Cancer Center at UPMC Horizon
Farrell , Pennsylvania
Highlands Oncology Group - Fayetteville
Fayetteville , Arkansas
Genesee Cancer and Blood Disease Treatment Center
Flint , Michigan
Genesee Hematology Oncology PC
Flint , Michigan
Genesys Hurley Cancer Institute
Flint , Michigan
Hurley Medical Center
Flint , Michigan
McLeod Regional Medical Center
Florence , South Carolina
Kaiser Permanente-Fontana
Fontana , California
Levine Cancer Institute - Rutherford
Forest City , North Carolina
Poudre Valley Hospital
Fort Collins , Colorado
Cancer Care and Hematology-Fort Collins
Fort Collins , Colorado
Eisenhower Army Medical Center
Fort Gordon , Georgia
Mercy Hospital Fort Smith
Fort Smith , Arkansas
Tarrant County Hospital District/JPS Health Network
Fort Worth , Texas
Beebe South Coastal Health Campus
Frankford , Delaware
Atrium Medical Center-Middletown Regional Hospital
Franklin , Ohio
Kaiser Permanente-Fremont
Fremont , California
Palo Alto Medical Foundation-Fremont
Fremont , California
Saint Luke's Cancer Institute - Fruitland
Fruitland , Idaho
Malcom Randall Veterans Administration Medical Center
Gainesville , Florida
Northeast Georgia Medical Center-Gainesville
Gainesville , Georgia
Kaiser Permanente-Gaithersburg Medical Center
Gaithersburg , Maryland
Illinois CancerCare-Galesburg
Galesburg , Illinois
Rex Hematology Oncology Associates-Garner
Garner , North Carolina
Levine Cancer Institute-Gaston
Gastonia , North Carolina
Northwestern Medicine Cancer Center Delnor
Geneva , Illinois
Tidelands Georgetown Memorial Hospital
Georgetown , South Carolina
Aurora Health Care Germantown Health Center
Germantown , Wisconsin
Adams Cancer Center
Gettysburg , Pennsylvania
Smilow Cancer Hospital Care Center at Glastonbury
Glastonbury , Connecticut
NorthShore University HealthSystem-Glenbrook Hospital
Glenview , Illinois
Addison Gilbert Hospital
Gloucester , Massachusetts
Southeastern Medical Oncology Center-Goldsboro
Goldsboro , North Carolina
Aurora Cancer Care-Grafton
Grafton , Wisconsin
Spectrum Health at Butterworth Campus
Grand Rapids , Michigan
Benefis Healthcare- Sletten Cancer Institute
Great Falls , Montana
UCHealth Greeley Hospital
Greeley , Colorado
Saint Vincent Hospital Cancer Center Green Bay
Green Bay , Wisconsin
Saint Vincent Hospital Cancer Center at Saint Mary's
Green Bay , Wisconsin
Aurora BayCare Medical Center
Green Bay , Wisconsin
UPMC Cancer Centers - Arnold Palmer Pavilion
Greensburg , Pennsylvania
Miami Valley Cancer Care and Infusion
Greenville , Ohio
Smilow Cancer Hospital Care Center at Greenwich
Greenwich , Connecticut
Gibbs Cancer Center-Pelham
Greer , South Carolina
Baptist Cancer Center-Grenada
Grenada , Mississippi
Legacy Mount Hood Medical Center
Gresham , Oregon
Great Lakes Cancer Management Specialists-Van Elslander Cancer Center
Grosse Pointe Woods , Michigan
Michigan Breast Specialists-Grosse Pointe Woods
Grosse Pointe Woods , Michigan
Smilow Cancer Hospital Care Center - Guilford
Guilford , Connecticut
Gulfport Memorial Hospital
Gulfport , Mississippi
The Cancer Institute of New Jersey Hamilton
Hamilton , New Jersey
Kaiser Permanente - Harbor City
Harbor City , California
UPMC Pinnacle Cancer Center/Community Osteopathic Campus
Harrisburg , Pennsylvania
Hartford Hospital
Hartford , Connecticut
Smilow Cancer Hospital Care Center at Saint Francis
Hartford , Connecticut
HaysMed University of Kansas Health System
Hays , Kansas
Advocate South Suburban Hospital
Hazel Crest , Illinois
AdventHealth Hendersonville
Hendersonville , North Carolina
NorthShore University HealthSystem-Highland Park Hospital
Highland Park , Illinois
South Carolina Cancer Specialists PC
Hilton Head Island , South Carolina
Edward Hines Jr VA Hospital
Hines , Illinois
Northwest Cancer Center - Hobart
Hobart , Indiana
Saint Mary Medical Center
Hobart , Indiana
Hawaii Cancer Care Inc - Waterfront Plaza
Honolulu , Hawaii
Queen's Cancer Cenrer - POB I
Honolulu , Hawaii
Queen's Medical Center
Honolulu , Hawaii
Straub Clinic and Hospital
Honolulu , Hawaii
Queen's Cancer Center - Kuakini
Honolulu , Hawaii
Kaiser Permanente Moanalua Medical Center
Honolulu , Hawaii
Terrebonne General Medical Center
Houma , Louisiana
Lyndon Baines Johnson General Hospital
Houston , Texas
Houston Methodist Hospital
Houston , Texas
Methodist Willowbrook Hospital
Houston , Texas
Edwards Comprehensive Cancer Center
Huntington , West Virginia
City of Hope at Huntington Beach
Huntington Beach , California
Cleveland Clinic Cancer Center Independence
Independence , Ohio
IRMC Cancer Center
Indiana , Pennsylvania
Saint Catherine Hospital
Indianapolis , Indiana
City of Hope at Irvine Lennar
Irvine , California
Kaiser Permanente-Irvine
Irvine , California
Southeastern Medical Oncology Center-Jacksonville
Jacksonville , North Carolina
Jersey City Medical Center
Jersey City , New Jersey
UPMC-Johnstown/John P. Murtha Regional Cancer Center
Johnstown , Pennsylvania
Bronson Methodist Hospital
Kalamazoo , Michigan
West Michigan Cancer Center
Kalamazoo , Michigan
Ascension Borgess Cancer Center
Kalamazoo , Michigan
Borgess Medical Center
Kalamazoo , Michigan
Kalispell Regional Medical Center
Kalispell , Montana
Truman Medical Centers
Kansas City , Missouri
Saint Luke's Hospital of Kansas City
Kansas City , Missouri
Kansas City Veterans Affairs Medical Center
Kansas City , Missouri
Aurora Cancer Care-Kenosha South
Kenosha , Wisconsin
Kettering Medical Center
Kettering , Ohio
Illinois CancerCare-Kewanee Clinic
Kewanee , Illinois
Gundersen Lutheran Medical Center
La Crosse , Wisconsin
Kaiser Permanente-Rock Creek
Lafayette , Colorado
Northwestern Medicine Lake Forest Hospital
Lake Forest , Illinois
The Watson Clinic
Lakeland , Florida
Monmouth Medical Center Southern Campus
Lakewood , New Jersey
Fairfield Medical Center
Lancaster , Ohio
Lancaster General Ann B Barshinger Cancer Institute
Lancaster , Pennsylvania
City of Hope Antelope Valley
Lancaster , California
Sparrow Hospital
Lansing , Michigan
Kaiser Permanente - Largo Medical Center
Largo , Maryland
OptumCare Cancer Care at Charleston
Las Vegas , Nevada
OptumCare Cancer Care at Fort Apache
Las Vegas , Nevada
Lawrence Memorial Hospital
Lawrence , Kansas
Northside Hospital - Gwinnett
Lawrenceville , Georgia
Dartmouth Hitchcock Medical Center/Dartmouth Cancer Center
Lebanon , New Hampshire
Sechler Family Cancer Center
Lebanon , Pennsylvania
Saint Luke's East - Lee's Summit
Lee's Summit , Missouri
University of Kentucky/Markey Cancer Center
Lexington , Kentucky
AMG Libertyville - Oncology
Libertyville , Illinois
Condell Memorial Hospital
Libertyville , Illinois
Atrium Health Lincoln/LCI-Lincolnton
Lincolnton , North Carolina
John L McClellan Memorial Veterans Hospital
Little Rock , Arkansas
University of Arkansas for Medical Sciences
Little Rock , Arkansas
Saint Barnabas Medical Center
Livingston , New Jersey
Trinity Health Saint Mary Mercy Livonia Hospital
Livonia , Michigan
Loma Linda University Medical Center
Loma Linda , California
Kaiser Permanente-Lone Tree
Lone Tree , Colorado
UCHealth Lone Tree Health Center
Lone Tree , Colorado
City of Hope at Long Beach Elm
Long Beach , California
Monmouth Medical Center
Long Branch , New Jersey
Kaiser Permanente Los Angeles Medical Center
Los Angeles , California
Kaiser Permanente West Los Angeles
Los Angeles , California
Cedars Sinai Medical Center
Los Angeles , California
Medical Center of the Rockies
Loveland , Colorado
Kaiser Permanente Lutherville - Timonium Medical Center
Lutherville , Maryland
Centra Lynchburg Hematology-Oncology Clinic Inc
Lynchburg , Virginia
Illinois CancerCare-Macomb
Macomb , Illinois
Great Lakes Cancer Management Specialists-Macomb Medical Campus
Macomb , Michigan
Michigan Breast Specialists-Macomb Township
Macomb , Michigan
University of Wisconsin Carbone Cancer Center
Madison , Wisconsin
Cleveland Clinic Cancer Center Mansfield
Mansfield , Ohio
Fairview Clinics and Surgery Center Maple Grove
Maple Grove , Minnesota
Aurora Bay Area Medical Group-Marinette
Marinette , Wisconsin
Memorial Hospital
Marysville , Ohio
Fremont - Rideout Cancer Center
Marysville , California
Levine Cancer Institute - Union West
Matthews , North Carolina
Carle Physician Group-Mattoon/Charleston
Mattoon , Illinois
Hillcrest Hospital Cancer Center
Mayfield Heights , Ohio
Loyola University Medical Center
Maywood , Illinois
UPMC Cancer Center at UPMC McKeesport
McKeesport , Pennsylvania
Kaiser Permanente Tysons Corner Medical Center
McLean , Virginia
UPMC Hillman Cancer Center at Rocco And Nancy Ortenzio Cancer Pavilion
Mechanicsburg , Pennsylvania
Aspirus Medford Hospital
Medford , Wisconsin
Riddle Memorial Hospital
Media , Pennsylvania
Summa Health Medina Medical Center
Medina , Ohio
Baptist Memorial Hospital and Cancer Center-Memphis
Memphis , Tennessee
Midstate Medical Center
Meriden , Connecticut
Saint Luke's Cancer Institute - Meridian
Meridian , Idaho
University of Miami Miller School of Medicine-Sylvester Cancer Center
Miami , Florida
Mount Sinai Medical Center
Miami Beach , Florida
Garnet Health Medical Center
Middletown , New York
Aurora Cancer Care-Milwaukee
Milwaukee , Wisconsin
Aurora Saint Luke's Medical Center
Milwaukee , Wisconsin
Aurora Sinai Medical Center
Milwaukee , Wisconsin
Abbott-Northwestern Hospital
Minneapolis , Minnesota
Hennepin County Medical Center
Minneapolis , Minnesota
Community Medical Hospital
Missoula , Montana
University of South Alabama Mitchell Cancer Institute
Mobile , Alabama
Memorial Medical Center
Modesto , California
Kaiser Permanente-Modesto
Modesto , California
Atrium Health Union/LCI-Union
Monroe , North Carolina
UPMC Hillman Cancer Center - Monroeville
Monroeville , Pennsylvania
Virtua Samson Cancer Center
Moorestown , New Jersey
West Virginia University Healthcare
Morgantown , West Virginia
UPMC Hillman Cancer Center - Part of Frick Hospital
Mount Pleasant , Pennsylvania
Knox Community Hospital
Mount Vernon , Ohio
ProHealth D N Greenwald Center
Mukwonago , Wisconsin
The Community Hospital
Munster , Indiana
Women's Diagnostic Center - Munster
Munster , Indiana
Trinity Health Muskegon Hospital
Muskegon , Michigan
Saint Luke's Cancer Institute - Nampa
Nampa , Idaho
Saint Alphonsus Cancer Care Center-Nampa
Nampa , Idaho
Vanderbilt University/Ingram Cancer Center
Nashville , Tennessee
UPMC Cancer Center-Natrona Heights
Natrona Heights , Pennsylvania
Baptist Memorial Hospital and Cancer Center-Union County
New Albany , Mississippi
The Hospital of Central Connecticut
New Britain , Connecticut
Rutgers Cancer Institute of New Jersey
New Brunswick , New Jersey
UPMC Hillman Cancer Center - New Castle
New Castle , Pennsylvania
Yale University
New Haven , Connecticut
University Medical Center New Orleans
New Orleans , Louisiana
New Ulm Medical Center
New Ulm , Minnesota
Mount Sinai Chelsea
New York , New York
Mount Sinai Hospital
New York , New York
Newark Beth Israel Medical Center
Newark , New Jersey
Helen F Graham Cancer Center
Newark , Delaware
Medical Oncology Hematology Consultants PA
Newark , Delaware
Licking Memorial Hospital
Newark , Ohio
Providence Newberg Medical Center
Newberg , Oregon
City of Hope Newport Beach
Newport Beach , California
Yale-New Haven Hospital North Haven Medical Center
North Haven , Connecticut
Arnold Palmer Cancer Center Medical Oncology Norwin
North Huntingdon , Pennsylvania
Cancer and Hematology Centers of Western Michigan - Norton Shores
Norton Shores , Michigan
Cancer Care Center of O'Fallon
O'Fallon , Illinois
Advocate Christ Medical Center
Oak Lawn , Illinois
Kaiser Permanente-Oakland
Oakland , California
ProHealth Oconomowoc Memorial Hospital
Oconomowoc , Wisconsin
Saint Vincent Hospital Cancer Center at Oconto Falls
Oconto Falls , Wisconsin
University of Oklahoma Health Sciences Center
Oklahoma City , Oklahoma
Mercy Hospital Oklahoma City
Oklahoma City , Oklahoma
Olathe Health Cancer Center
Olathe , Kansas
Saint Alphonsus Medical Center-Ontario
Ontario , Oregon
Kaiser Permanente-Ontario
Ontario , California
Smilow Cancer Hospital-Orange Care Center
Orange , Connecticut
Providence Willamette Falls Medical Center
Oregon City , Oregon
Northwestern Medicine Orland Park
Orland Park , Illinois
Vince Lombardi Cancer Clinic - Oshkosh
Oshkosh , Wisconsin
Upstate Cancer Center at Oswego
Oswego , New York
Illinois CancerCare-Ottawa Clinic
Ottawa , Illinois
Owensboro Health Mitchell Memorial Cancer Center
Owensboro , Kentucky
Baptist Memorial Hospital and Cancer Center-Oxford
Oxford , Mississippi
Palo Alto Medical Foundation Health Care
Palo Alto , California
Kaiser Permanente - Panorama City
Panorama City , California
Paoli Memorial Hospital
Paoli , Pennsylvania
Advocate Lutheran General Hospital
Park Ridge , Illinois
Lahey Medical Center-Peabody
Peabody , Massachusetts
Illinois CancerCare-Pekin
Pekin , Illinois
Illinois CancerCare-Peoria
Peoria , Illinois
Mercy Health Perrysburg Cancer Center
Perrysburg , Ohio
Illinois CancerCare-Peru
Peru , Illinois
Thomas Jefferson University Hospital
Philadelphia , Pennsylvania
Jefferson Torresdale Hospital
Philadelphia , Pennsylvania
Temple University Hospital
Philadelphia , Pennsylvania
FirstHealth of the Carolinas-Moore Regional Hospital
Pinehurst , North Carolina
Freeman Physician Group of Pittsburg
Pittsburg , Kansas
UPMC-Saint Margaret
Pittsburgh , Pennsylvania
UPMC-Mercy Hospital
Pittsburgh , Pennsylvania
University of Pittsburgh Cancer Institute (UPCI)
Pittsburgh , Pennsylvania
UPMC-Passavant Hospital
Pittsburgh , Pennsylvania
UPMC-Saint Clair Hospital Cancer Center
Pittsburgh , Pennsylvania
UM Sylvester Comprehensive Cancer Center at Plantation
Plantation , Florida
Saint Joseph Mercy Oakland
Pontiac , Michigan
Legacy Good Samaritan Hospital and Medical Center
Portland , Oregon
Providence Portland Medical Center
Portland , Oregon
Providence Saint Vincent Medical Center
Portland , Oregon
Kaiser Permanente Northwest
Portland , Oregon
Oregon Health and Science University
Portland , Oregon
Southern Ohio Medical Center
Portsmouth , Ohio
Kootenai Clinic Cancer Services - Post Falls
Post Falls , Idaho
Illinois CancerCare-Princeton
Princeton , Illinois
Aurora Cancer Care-Racine
Racine , Wisconsin
UNC Rex Healthcare
Raleigh , North Carolina
UNC Rex Cancer Center of Wakefield
Raleigh , North Carolina
Corewell Health Reed City Hospital
Reed City , Michigan
Beebe Health Campus
Rehoboth Beach , Delaware
Renown Regional Medical Center
Reno , Nevada
Ascension Saint Mary's Hospital
Rhinelander , Wisconsin
Kaiser Permanente-Riverside
Riverside , California
University of Rochester
Rochester , New York
Levine Cancer Institute-Rock Hill
Rock Hill , South Carolina
Highlands Oncology Group - Rogers
Rogers , Arkansas
Kaiser Permanente-Roseville
Roseville , California
Sutter Roseville Medical Center
Roseville , California
Kaiser Permanente Downtown Commons
Sacramento , California
Sutter Medical Center Sacramento
Sacramento , California
University of California Davis Comprehensive Cancer Center
Sacramento , California
Kaiser Permanente-South Sacramento
Sacramento , California
Norris Cotton Cancer Center-North
Saint Johnsbury , Vermont
Lakeland Medical Center Saint Joseph
Saint Joseph , Michigan
Marie Yeager Cancer Center
Saint Joseph , Michigan
Park Nicollet Clinic - Saint Louis Park
Saint Louis Park , Minnesota
Regions Hospital
Saint Paul , Minnesota
United Hospital
Saint Paul , Minnesota
Sainte Genevieve County Memorial Hospital
Sainte Genevieve , Missouri
Salina Regional Health Center
Salina , Kansas
Huntsman Cancer Institute/University of Utah
Salt Lake City , Utah
Kaiser Permanente-San Diego Zion
San Diego , California
California Pacific Medical Center-Pacific Campus
San Francisco , California
Kaiser Permanente-San Francisco
San Francisco , California
Kaiser Permanente-Santa Teresa-San Jose
San Jose , California
Kaiser Permanente San Leandro
San Leandro , California
Kaiser Permanente-San Marcos
San Marcos , California
Kaiser San Rafael-Gallinas
San Rafael , California
Kootenai Cancer Clinic
Sandpoint , Idaho
North Coast Cancer Care
Sandusky , Ohio
Kaiser Permanente Medical Center - Santa Clara
Santa Clara , California
Palo Alto Medical Foundation-Santa Cruz
Santa Cruz , California
Kaiser Permanente-Santa Rosa
Santa Rosa , California
Memorial Health University Medical Center
Savannah , Georgia
Lewis Cancer and Research Pavilion at Saint Joseph's/Candler
Savannah , Georgia
Community Medical Center
Scranton , Pennsylvania
FHCC South Lake Union
Seattle , Washington
Fred Hutchinson Cancer Research Center
Seattle , Washington
University of Washington Medical Center - Montlake
Seattle , Washington
PeaceHealth United General Medical Center
Sedro-Woolley , Washington
UPMC Cancer Center at UPMC Northwest
Seneca , Pennsylvania
Saint Vincent Hospital Cancer Center at Sheboygan
Sheboygan , Wisconsin
Vince Lombardi Cancer Clinic-Sheboygan
Sheboygan , Wisconsin
Atrium Health Cleveland/LCI-Cleveland
Shelby , North Carolina
Memorial Hospital East
Shiloh , Illinois
Sanford Cancer Center Oncology Clinic
Sioux Falls , South Dakota
Sanford USD Medical Center - Sioux Falls
Sioux Falls , South Dakota
Robert Wood Johnson University Hospital Somerset
Somerville , New Jersey
Memorial Hospital of South Bend
South Bend , Indiana
City of Hope South Pasadena
South Pasadena , California
Kaiser Permanente-South San Francisco
South San Francisco , California
Baptist Memorial Hospital and Cancer Center-Desoto
Southhaven , Mississippi
Spartanburg Medical Center
Spartanburg , South Carolina
Highlands Oncology Group
Springdale , Arkansas
Springfield Regional Cancer Center
Springfield , Ohio
Springfield Regional Medical Center
Springfield , Ohio
Southern Illinois University School of Medicine
Springfield , Illinois
Springfield Clinic
Springfield , Illinois
Memorial Medical Center
Springfield , Illinois
Baystate Medical Center
Springfield , Massachusetts
Mercy Hospital Springfield
Springfield , Missouri
Missouri Baptist Medical Center
St Louis , Missouri
Siteman Cancer Center at Christian Hospital
St Louis , Missouri
Mercy Hospital Saint Louis
St Louis , Missouri
Washington University School of Medicine
St Louis , Missouri
Veteran's Affairs Medical Center - Saint Louis
St Louis , Missouri
Mercy Hospital South
St Louis , Missouri
Siteman Cancer Center-South County
St Louis , Missouri
Smilow Cancer Hospital Care Center at Long Ridge
Stamford , Connecticut
Stamford Hospital/Bennett Cancer Center
Stamford , Connecticut
Bhadresh Nayak MD PC-Sterling Heights
Sterling Heights , Michigan
Trinity's Tony Teramana Cancer Center
Steubenville , Ohio
Ascension Saint Michael's Hospital
Stevens Point , Wisconsin
Stony Brook University Medical Center
Stony Brook , New York
Cleveland Clinic Cancer Center Strongsville
Strongsville , Ohio
Saint Vincent Hospital Cancer Center at Sturgeon Bay
Sturgeon Bay , Wisconsin
Houston Methodist Sugar Land Hospital
Sugar Land , Texas
Missouri Baptist Sullivan Hospital
Sullivan , Missouri
Aurora Medical Center in Summit
Summit , Wisconsin
Palo Alto Medical Foundation-Sunnyvale
Sunnyvale , California
BJC Outpatient Center at Sunset Hills
Sunset Hills , Missouri
State University of New York Upstate Medical University
Syracuse , New York
SUNY Upstate Medical Center-Community Campus
Syracuse , New York
Northwest Medical Specialties PLLC
Tacoma , Washington
Moffitt Cancer Center-International Plaza
Tampa , Florida
Moffitt Cancer Center
Tampa , Florida
Montefiore Medical Center-Einstein Campus
The Bronx , New York
Montefiore Medical Center-Weiler Hospital
The Bronx , New York
Montefiore Medical Center - Moses Campus
The Bronx , New York
Tift Regional Medical Center
Tifton , Georgia
Mercy Health - Saint Anne Hospital
Toledo , Ohio
Toledo Clinic Cancer Centers-Toledo
Toledo , Ohio
Community Medical Center
Toms River , New Jersey
University of Kansas Health System Saint Francis Campus
Topeka , Kansas
Torrance Memorial Physician Network - Cancer Care
Torrance , California
Smilow Cancer Hospital-Torrington Care Center
Torrington , Connecticut
Munson Medical Center
Traverse City , Michigan
Upper Valley Medical Center
Troy , Ohio
Gene Upshaw Memorial Tahoe Forest Cancer Center
Truckee , California
Smilow Cancer Hospital Care Center-Trumbull
Trumbull , Connecticut
Legacy Meridian Park Hospital
Tualatin , Oregon
Banner University Medical Center - Tucson
Tucson , Arizona
University of Arizona Cancer Center-North Campus
Tucson , Arizona
Saint Luke's Cancer Institute - Twin Falls
Twin Falls , Idaho
Vince Lombardi Cancer Clinic-Two Rivers
Two Rivers , Wisconsin
UPMC Cancer Center-Uniontown
Uniontown , Pennsylvania
City of Hope Upland
Upland , California
Carle Cancer Center
Urbana , Illinois
South Georgia Medical Center/Pearlman Cancer Center
Valdosta , Georgia
Kaiser Permanente-Vallejo
Vallejo , California
Sutter Solano Medical Center/Cancer Center
Vallejo , California
Northwest Cancer Center - Valparaiso
Valparaiso , Indiana
Legacy Cancer Institute Medical Oncology and Day Treatment
Vancouver , Washington
Legacy Salmon Creek Hospital
Vancouver , Washington
Upstate Cancer Center at Verona
Verona , New York
MD Anderson Cancer Center at Cooper-Voorhees
Voorhees Township , New Jersey
Virtua Voorhees
Voorhees Township , New Jersey
Kaiser Permanente-Walnut Creek
Walnut Creek , California
Advanced Breast Care Center PLLC
Warren , Michigan
Great Lakes Cancer Management Specialists-Macomb Professional Building
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