Multi-omics Research of Idopathic Normal Pressure Hydrocephalus (iNPH)

The research is designed to study the prognostic factors of ventriculoperitoneal (VP) shunt for iNPH by multi-omics research

Preoperative T1-MRI, functional MRI and diffusion MRI imaging data of iNPH patients were collected. The clinical assessment was performed before/after the lumbar puncture test and 6 months after VP shunt. Clinical assessment included Mini-mental State Examination (MMSE), gait scores, Kiefer score, and Modified Rankin Scale (mRS). The cerebrospinal fluid was collected by tap-test, and 6 months after surgery by puncturing in the VP device pump. Methods- The primary methods used are: 1. The cerebrospinal fluid proteomic analysis of iNPH patients before and after VP shunt surgery. 2. The structral and functional MRI analysis of iNPH patients 3. The clinical assessment of MMSE, gait scores, Kiefer score, and mRS. Objective- To study the prognostic factors of VP shunt for iNPH.

Inclusion Criteria: * Age ≥ 60 years; * Diagnosis of iNPH based on clinical assessment * Participant is able to give written informed consent Exclusion Criteria: * Combining AD and Parkinson's disease and other nervous system diseases * Participant is not medically available for shunt surgery * Secondary NPH